Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   Q3V60_RS00225 Genome accession   NZ_CP130516
Coordinates   51920..53269 (-) Length   449 a.a.
NCBI ID   WP_000815640.1    Uniprot ID   -
Organism   Staphylococcus aureus strain SA27-SX     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 35905..65498 51920..53269 within 0
SCCmec 43505..58440 51920..53269 within 0


Gene organization within MGE regions


Location: 35905..65498
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  Q3V60_RS00145 - 35905..36579 (-) 675 WP_001106057.1 IS6-like element IS257 family transposase -
  Q3V60_RS00150 - 36670..37653 (-) 984 Protein_27 protein rep -
  Q3V60_RS00155 mobV 37898..39160 (-) 1263 WP_000119405.1 MobV family relaxase -
  Q3V60_RS00160 bleO 39668..40072 (-) 405 WP_001242578.1 bleomycin binding protein -
  Q3V60_RS00165 aadD1 40289..41059 (-) 771 WP_001795128.1 aminoglycoside O-nucleotidyltransferase ANT(4')-Ia -
  Q3V60_RS00170 - 41252..41926 (-) 675 WP_001106057.1 IS6-like element IS257 family transposase -
  Q3V60_RS00175 - 42191..42934 (+) 744 WP_000958858.1 glycerophosphoryl diester phosphodiesterase -
  Q3V60_RS00180 - 43031..43459 (+) 429 WP_077156111.1 MaoC family dehydratase -
  Q3V60_RS00185 mecA 43505..45514 (-) 2010 WP_001801873.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  Q3V60_RS00190 - 45611..46597 (+) 987 WP_001549960.1 beta-lactam sensor/signal transducer MecR1 -
  Q3V60_RS00195 - 46569..46829 (+) 261 WP_001549961.1 type I restriction enzyme endonuclease domain-containing protein -
  Q3V60_RS00200 - 46820..48427 (-) 1608 Protein_37 IS1182 family transposase -
  Q3V60_RS00205 - 48479..48985 (-) 507 WP_001092189.1 DUF1643 domain-containing protein -
  Q3V60_RS00210 - 49000..49311 (-) 312 WP_000700851.1 DUF960 family protein -
  Q3V60_RS00215 - 49398..49748 (-) 351 WP_000849672.1 SAUGI family uracil-DNA glycosylase inhibitor -
  Q3V60_RS00220 ccrB 50270..51898 (-) 1629 WP_001186608.1 cassette chromosome recombinase CcrB Machinery gene
  Q3V60_RS00225 ccrA 51920..53269 (-) 1350 WP_000815640.1 cassette chromosome recombinase CcrA Machinery gene
  Q3V60_RS00230 - 53503..55296 (-) 1794 WP_000079473.1 cassette chromosome replicative helicase -
  Q3V60_RS00235 - 55296..55592 (-) 297 WP_000273823.1 cassette chromosome ssDNA-binding protein -
  Q3V60_RS00240 - 55785..56831 (-) 1047 WP_001042023.1 hypothetical protein -
  Q3V60_RS00245 - 57286..58440 (+) 1155 WP_000912116.1 ATP-binding protein -
  Q3V60_RS00250 - 58470..59270 (+) 801 WP_000749913.1 abortive infection family protein -
  Q3V60_RS00255 - 59451..61181 (-) 1731 WP_000363097.1 nuclease domain-containing protein -
  Q3V60_RS00260 - 61165..63069 (-) 1905 WP_000795079.1 McrB family protein -
  Q3V60_RS00265 - 63072..63989 (-) 918 WP_001814443.1 hypothetical protein -
  Q3V60_RS00270 - 64239..64460 (+) 222 WP_025175007.1 hypothetical protein -
  Q3V60_RS00275 - 65016..65498 (+) 483 Protein_52 transposase -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52663.34 Da        Isoelectric Point: 9.9639

>NTDB_id=859171 Q3V60_RS00225 WP_000815640.1 51920..53269(-) (ccrA) [Staphylococcus aureus strain SA27-SX]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQITQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRLKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRLQKQTKQTPSDNQLKQKIKCPCCNATLTNMTIRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CRDFYQNQRIYTKIKSAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHIIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=859171 Q3V60_RS00225 WP_000815640.1 51920..53269(-) (ccrA) [Staphylococcus aureus strain SA27-SX]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGTCGCAAAGATAATCGTAGTGGGT
ATCGACAAATAACACAATTAATTCAACAAGGACAGTGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACGTACCATGTTCATATCTTAAGCGTACATGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGACTCAAGCTTAATATCTTCATCAGTTTAGCCGAACTTGAATCGGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACACATGCACCTTTTGGTTACGAATATCAC
AACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATTGCAAAAACAAACCAAACAGACACCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCATTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCACGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCCGAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAAGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATTGATGCAGAAACGTTCA
GAGAGCAAACACAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGGCATCAAATACAACACATCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATTGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-321)

Recombinase (Recombinase)

(169-248)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus N315

97.55

100

0.976
  ccrA Staphylococcus aureus COL

75.947

100

0.759