Detailed information NTG0854434

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: QYT29_RS12210
• Genome accession: NZ_CP129560
• Coordinates: 2479253..2480296 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 727M
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2474253..2485296

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QYT29_RS12180 (QYT29_12160)	-	2474868..2474978 (+)	111	WP_014937049.1	hypothetical protein	-
QYT29_RS12185 (QYT29_12165)	-	2475007..2475420 (+)	414	WP_025174370.1	hypothetical protein	-
QYT29_RS12190 (QYT29_12170)	-	2475609..2476595 (-)	987	WP_000999712.1	FUSC family protein	-
QYT29_RS12195 (QYT29_12175)	map	2477179..2477937 (+)	759	WP_000636145.1	type I methionyl aminopeptidase	-
QYT29_RS12200 (QYT29_12180)	-	2478154..2478540 (+)	387	WP_001110182.1	hypothetical protein	-
QYT29_RS12205 (QYT29_12185)	liaF	2478555..2479256 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
QYT29_RS12210 (QYT29_12190)	vraS	2479253..2480296 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
QYT29_RS12215 (QYT29_12195)	vraR	2480286..2480915 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
QYT29_RS12220 (QYT29_12200)	-	2481028..2482245 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
QYT29_RS12225 (QYT29_12205)	-	2482523..2482798 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
QYT29_RS12230 (QYT29_12210)	-	2482805..2483269 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
QYT29_RS12235 (QYT29_12215)	-	2483416..2483616 (+)	201	WP_000180460.1	DUF1128 family protein	-
QYT29_RS12240 (QYT29_12220)	-	2483619..2484875 (+)	1257	WP_074347694.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=854434 QYT29_RS12210 WP_001017131.1 2479253..2480296(+) (vraS) [Staphylococcus aureus strain 727M]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=854434 QYT29_RS12210 WP_001017131.1 2479253..2480296(+) (vraS) [Staphylococcus aureus strain 727M]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1