Detailed information NTG0854240

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: QYT32_RS13695
• Genome accession: NZ_CP129553
• Coordinates: 2771002..2772045 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 704D
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2766002..2777045

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QYT32_RS13665 (QYT32_13660)	-	2766557..2766667 (+)	111	WP_001790257.1	hypothetical protein	-
QYT32_RS13670 (QYT32_13665)	-	2766696..2767109 (+)	414	WP_001643743.1	hypothetical protein	-
QYT32_RS13675 (QYT32_13670)	-	2767298..2768284 (-)	987	WP_001014423.1	FUSC family protein	-
QYT32_RS13680 (QYT32_13675)	map	2768928..2769686 (+)	759	WP_123090064.1	type I methionyl aminopeptidase	-
QYT32_RS13685 (QYT32_13680)	-	2769903..2770289 (+)	387	WP_001110178.1	hypothetical protein	-
QYT32_RS13690 (QYT32_13685)	liaF	2770304..2771005 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
QYT32_RS13695 (QYT32_13690)	vraS	2771002..2772045 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
QYT32_RS13700 (QYT32_13695)	vraR	2772035..2772664 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
QYT32_RS13705 (QYT32_13700)	-	2772777..2773994 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
QYT32_RS13710 (QYT32_13705)	-	2774272..2774547 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
QYT32_RS13715 (QYT32_13710)	-	2774554..2775018 (-)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
QYT32_RS13720 (QYT32_13715)	-	2775165..2775365 (+)	201	WP_000180460.1	DUF1128 family protein	-
QYT32_RS13725 (QYT32_13720)	-	2775368..2776624 (+)	1257	WP_001793983.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=854240 QYT32_RS13695 WP_001017131.1 2771002..2772045(+) (vraS) [Staphylococcus aureus strain 704D]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=854240 QYT32_RS13695 WP_001017131.1 2771002..2772045(+) (vraS) [Staphylococcus aureus strain 704D]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1