Detailed information NTG0852812

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: QYE85_RS04375
• Genome accession: NZ_CP129365
• Coordinates: 930692..931738 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain CKFA-393
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 925692..936738

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QYE85_RS04350	-	926833..927369 (+)	537	WP_002470337.1	hypothetical protein	-
QYE85_RS04355	-	927520..928506 (-)	987	WP_001830388.1	aromatic acid exporter family protein	-
QYE85_RS04360	map	928680..929435 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
QYE85_RS04365	-	929593..929979 (+)	387	WP_001830382.1	hypothetical protein	-
QYE85_RS04370	liaF	929994..930695 (+)	702	WP_001830436.1	cell wall-active antibiotics response protein LiaF	-
QYE85_RS04375	vraS	930692..931738 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
QYE85_RS04380	vraR	931728..932357 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
QYE85_RS04385	-	932414..933592 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
QYE85_RS04390	-	933999..934283 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
QYE85_RS04395	-	934291..934755 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
QYE85_RS04400	-	934896..935111 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
QYE85_RS04405	-	935113..936354 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=852812 QYE85_RS04375 WP_001830374.1 930692..931738(+) (vraS) [Staphylococcus epidermidis strain CKFA-393]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=852812 QYE85_RS04375 WP_001830374.1 930692..931738(+) (vraS) [Staphylococcus epidermidis strain CKFA-393]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92