Detailed information NTG0851371

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: LLUC029_RS12135
• Genome accession: NZ_CP129163
• Coordinates: 2321340..2322371 (-)
• Length: 343 a.a.
• NCBI ID: WP_011677213.1
• Uniprot ID: A0A166ZHD8
• Organism: Lactococcus cremoris strain UC029
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 2316340..2327371

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LLUC029_RS12105 (LLUC029_12125)	-	2317546..2318043 (-)	498	WP_032951474.1	nitroreductase family protein	-
LLUC029_RS12110 (LLUC029_12130)	-	2318030..2318239 (-)	210	WP_011677212.1	hypothetical protein	-
LLUC029_RS12115 (LLUC029_12135)	-	2318526..2319416 (+)	891	WP_081196119.1	IS982-like element IS982B family transposase	-
LLUC029_RS12120 (LLUC029_12140)	kwcM	2319523..2320311 (-)	789	WP_396425124.1	KxxxW cyclic peptide radical SAM maturase	-
LLUC029_RS12125 (LLUC029_12145)	-	2320254..2320841 (-)	588	WP_396425052.1	radical SAM protein	-
LLUC029_RS12130 (LLUC029_12150)	-	2320909..2321022 (-)	114	WP_011836076.1	KxxxW-cyclized peptide pheromone	-
LLUC029_RS12135 (LLUC029_12155)	sepM	2321340..2322371 (-)	1032	WP_011677213.1	SepM family pheromone-processing serine protease	Regulator
LLUC029_RS12140 (LLUC029_12160)	coaD	2322355..2322855 (-)	501	WP_011677214.1	pantetheine-phosphate adenylyltransferase	-
LLUC029_RS12145 (LLUC029_12165)	rsmD	2322903..2323442 (-)	540	WP_031286167.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
LLUC029_RS12150 (LLUC029_12170)	-	2323613..2324833 (-)	1221	WP_011677216.1	MFS transporter	-
LLUC029_RS12155 (LLUC029_12175)	lmrP	2324917..2326146 (-)	1230	Protein_2365	multidrug efflux MFS transporter LmrP	-
LLUC029_RS12160 (LLUC029_12180)	-	2326202..2327092 (-)	891	WP_396425053.1	IS982-like element IS982B family transposase	-

Sequence

Protein

• Length: 343 a.a.
• Molecular weight: 37398.03 Da
• Isoelectric Point: 9.8499

>NTDB_id=851371 LLUC029_RS12135 WP_011677213.1 2321340..2322371(-) (sepM) [Lactococcus cremoris strain UC029]
MKKKNKKISPKLKWGISIGLIIVALLVLVYPTNYYVEMPGTTEPLGKMVKVEGKKDEHKGDFFLTTVQIARANLATMIYS
HFNSFTSIYSEQEMTGGLNDAQFNRVNQFYMETAQNTAVYQAFKLANKPYELKYEGVYVLDIAKNSTFKNKLELSDTITA
VNGEEFKSSADMIAYVSKQKVGDSVTIEYTRIDGSKHKSTGKYIKIANGKTGIGIGLVDHTEVVTDPKVTVNAGSIGGPS
AGIMFTLEIYSQLTGKDLRGGREIAGTGTIEHDGSIGQIGGVDKKVATASKEGAKVFLVPDSGTKKESSNNYLGAKAAAK
KLKTKMKIVPVKTIQDALDYLEK

Nucleotide

• Length: 1032 bp

>NTDB_id=851371 LLUC029_RS12135 WP_011677213.1 2321340..2322371(-) (sepM) [Lactococcus cremoris strain UC029]
ATGAAGAAAAAAAATAAAAAAATCAGTCCCAAATTAAAATGGGGCATCTCTATTGGTCTGATTATTGTCGCTCTCCTTGT
TTTAGTGTATCCAACAAATTATTATGTGGAAATGCCTGGAACAACCGAGCCATTAGGAAAAATGGTCAAAGTCGAAGGAA
AAAAAGATGAGCACAAAGGTGACTTTTTCCTTACTACCGTTCAAATTGCGCGCGCTAATCTTGCCACAATGATTTACAGT
CATTTTAATAGTTTTACAAGCATTTACAGTGAACAAGAAATGACCGGTGGCCTTAATGATGCGCAGTTCAATCGTGTCAA
CCAGTTTTACATGGAAACGGCACAAAATACAGCCGTTTATCAGGCCTTCAAGTTGGCAAATAAACCCTATGAACTGAAAT
ATGAAGGGGTTTATGTCCTTGATATCGCTAAAAATTCGACTTTTAAAAATAAATTGGAACTTTCGGACACGATTACAGCA
GTCAATGGGGAAGAATTTAAATCAAGTGCAGATATGATTGCTTACGTTTCGAAGCAAAAAGTCGGCGATTCAGTTACCAT
TGAATATACACGGATTGATGGAAGTAAACACAAGTCTACTGGAAAATATATCAAAATCGCTAATGGAAAAACTGGAATCG
GAATTGGACTAGTTGACCATACTGAAGTAGTCACAGACCCAAAAGTTACAGTCAATGCAGGTTCAATCGGTGGACCATCT
GCCGGAATAATGTTTACACTAGAGATTTACAGTCAGTTGACAGGTAAAGATTTACGTGGTGGTCGCGAAATAGCAGGAAC
TGGAACGATTGAACATGATGGAAGCATTGGCCAAATCGGTGGGGTTGATAAAAAAGTAGCTACTGCTAGCAAAGAAGGCG
CAAAAGTTTTCTTAGTTCCTGACTCAGGCACCAAAAAAGAAAGCAGCAATAACTATCTTGGAGCCAAAGCAGCCGCTAAA
AAATTAAAAACGAAGATGAAAATTGTTCCCGTCAAGACTATTCAGGACGCTTTAGATTATTTAGAAAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (229-339)

• PDZ domain (PDZ_2) (135-193)

3D structure

• AlphaFold DB: A0A166ZHD8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	48.696	100	0.49