Detailed information NTG0851352

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: LLUC029_RS10105
• Genome accession: NZ_CP129163
• Coordinates: 1961075..1963321 (-)
• Length: 748 a.a.
• NCBI ID: WP_011675568.1
• Uniprot ID: -
• Organism: Lactococcus cremoris strain UC029
• Function: degradation of ComX (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
ICE	1936481..1961313	1961075..1963321	flank	-238

Gene organization within MGE regions

Location: 1936481..1963321

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LLUC029_RS09960 (LLUC029_09990)	-	1936766..1937701 (+)	936	WP_031559015.1	IS30 family transposase	-
LLUC029_RS09965 (LLUC029_09995)	-	1937746..1939299 (+)	1554	WP_396425043.1	AAA family ATPase	-
LLUC029_RS09970 (LLUC029_10000)	-	1939565..1940335 (-)	771	WP_063280755.1	hypothetical protein	-
LLUC029_RS09975 (LLUC029_10005)	-	1940775..1941368 (-)	594	WP_231099849.1	site-specific integrase	-
LLUC029_RS09980 (LLUC029_10010)	-	1941344..1941898 (-)	555	WP_231099848.1	hypothetical protein	-
LLUC029_RS09985 (LLUC029_10015)	-	1941958..1942167 (-)	210	WP_014573057.1	hypothetical protein	-
LLUC029_RS09990 (LLUC029_10020)	-	1942173..1943159 (-)	987	WP_194942508.1	Replication initiation protein	-
LLUC029_RS09995 (LLUC029_10025)	-	1943234..1943461 (-)	228	WP_021166325.1	hypothetical protein	-
LLUC029_RS10000 (LLUC029_10030)	-	1943547..1944658 (+)	1112	WP_308781095.1	IS3-like element IS981 family transposase	-
LLUC029_RS10005 (LLUC029_10035)	-	1944720..1945316 (-)	597	WP_032951345.1	lipoprotein BA_5634 family protein	-
LLUC029_RS10010 (LLUC029_10040)	-	1945543..1945986 (-)	444	WP_011675583.1	GNAT family N-acetyltransferase	-
LLUC029_RS10015 (LLUC029_10045)	-	1946019..1948346 (-)	2328	WP_032951347.1	cation-translocating P-type ATPase	-
LLUC029_RS10020 (LLUC029_10050)	-	1948532..1948717 (+)	186	WP_011675581.1	2-hydroxymuconate tautomerase	-
LLUC029_RS10025 (LLUC029_10055)	-	1948864..1949559 (+)	696	WP_011675580.1	phosphopantothenate--cysteine ligase	-
LLUC029_RS10030 (LLUC029_10060)	coaC	1949552..1950088 (+)	537	WP_014573068.1	phosphopantothenoylcysteine decarboxylase	-
LLUC029_RS10035 (LLUC029_10065)	-	1950105..1950695 (+)	591	WP_011675579.1	ECF transporter S component	-
LLUC029_RS10040 (LLUC029_10070)	-	1950790..1951548 (+)	759	WP_011675578.1	HAD-IIB family hydrolase	-
LLUC029_RS10045 (LLUC029_10075)	yidC	1951723..1952685 (+)	963	WP_011675577.1	membrane protein insertase YidC	-
LLUC029_RS10050 (LLUC029_10080)	fabI	1952871..1953623 (-)	753	WP_011675576.1	enoyl-ACP reductase FabI	-
LLUC029_RS10055 (LLUC029_10085)	fabZ	1953899..1954354 (+)	456	WP_011675575.1	3-hydroxyacyl-ACP dehydratase FabZ	-
LLUC029_RS10060 (LLUC029_10090)	-	1954406..1954603 (-)	198	WP_308297647.1	M20/M25/M40 family metallo-hydrolase	-
LLUC029_RS10065 (LLUC029_10095)	-	1954759..1954989 (-)	231	Protein_1981	peptidase dimerization domain-containing protein	-
LLUC029_RS10070 (LLUC029_10100)	-	1954986..1955525 (-)	540	WP_014573071.1	M20 family metallopeptidase	-
LLUC029_RS10075 (LLUC029_10105)	-	1955540..1956349 (-)	810	WP_080513978.1	ABC transporter substrate-binding protein	-
LLUC029_RS10080 (LLUC029_10110)	uvrB	1956543..1958621 (-)	2079	WP_032951352.1	excinuclease ABC subunit UvrB	-
LLUC029_RS10085 (LLUC029_10115)	-	1958683..1959087 (-)	405	WP_011675572.1	RNA pyrophosphohydrolase	-
LLUC029_RS10090 (LLUC029_10120)	def	1959242..1959877 (+)	636	WP_021166306.1	peptide deformylase	-
LLUC029_RS10095 (LLUC029_10125)	-	1960101..1960310 (-)	210	Protein_1987	type I glyceraldehyde-3-phosphate dehydrogenase	-
LLUC029_RS10100 (LLUC029_10130)	-	1960479..1960949 (+)	471	WP_032951355.1	Rrf2 family transcriptional regulator	-
LLUC029_RS10105 (LLUC029_10135)	clpC	1961075..1963321 (-)	2247	WP_011675568.1	ATP-dependent Clp protease ATP-binding subunit	Regulator

Sequence

Protein

• Length: 748 a.a.
• Molecular weight: 83194.00 Da
• Isoelectric Point: 4.7590

>NTDB_id=851352 LLUC029_RS10105 WP_011675568.1 1961075..1963321(-) (clpC) [Lactococcus cremoris strain UC029]
MLCQNCNINEATIHLYTSVNGQKKQIDLCQNCYQIMKSGGQEALFGAGNASNGNSDEPFNPFNDIFSALQGQDFNGAASN
QTPPTQTGGRGPRGPQNPRAKQPKGMLEEFGINITESARRGEIDPVIGRDEEIKRVIEILNRRTKNNPVLIGEPGVGKTA
VVEGLAQKIVDGDVPQKLQNKEVIRLDVVSLVQGTGIRGQFEERMQKLMDEIRKRNDVIMFIDEIHEIVGAGSAGDGNMD
AGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVDETITILRGIQARYEDYHHVKYTDEAIEAAAH
LSNRYIQDRFLPDKAIDLLDESGSKKNLTLKFVDPEDINRRIADAESKKNEATKAEDFEKAAHFRDQISKLRELQKQEVT
DEDMPVITEKDIEQIVEQKTQIPVGDLKEKEQTQLINLADDLKAHVIGQDEAVDKISKAIRRSRVGLGKPNRPIGSFLFV
GPTGVGKTELAKQLAKELFGSSESMIRFDMSEYMEKHSVAKLIGAPPGYVGYEEAGQLTERVRRNPYSLILLDEIEKAHP
DVMHMFLQILEDGRLTDAQGRTVSFKDSLIIMTSNAGTGKVEASVGFGAAREGRTKSVLGQLGDFFSPEFMNRFDGIIEF
SALSKENLLKIVDLMLDEVNEQIGRNDIHLSVTQAAKEKLVDLGYNPAMGARPLRRTIQENIEDSIADFYIEHPEYKQLV
ADLIDDKIVISNQTQETAETTDEEVPAE

Nucleotide

• Length: 2247 bp

>NTDB_id=851352 LLUC029_RS10105 WP_011675568.1 1961075..1963321(-) (clpC) [Lactococcus cremoris strain UC029]
ATGCTTTGTCAAAATTGTAATATTAATGAAGCGACGATTCACCTTTACACAAGTGTAAATGGTCAGAAAAAACAAATTGA
TTTGTGCCAAAACTGTTATCAAATTATGAAATCTGGTGGTCAAGAAGCTTTATTTGGCGCAGGAAATGCCTCAAATGGAA
ATTCTGATGAACCCTTTAATCCGTTTAACGATATCTTCAGTGCTTTGCAAGGTCAAGATTTTAATGGGGCAGCAAGTAAT
CAAACTCCCCCAACACAAACGGGTGGGCGTGGTCCGCGTGGTCCACAAAATCCTCGGGCAAAACAACCTAAAGGGATGCT
AGAAGAATTCGGTATTAATATCACCGAATCAGCTCGTCGTGGCGAAATTGACCCAGTGATTGGGCGTGATGAAGAAATCA
AACGTGTTATTGAGATTTTAAATCGCAGAACTAAGAATAATCCAGTGCTAATTGGTGAACCTGGTGTTGGTAAAACAGCA
GTTGTTGAAGGTTTAGCACAAAAAATAGTCGATGGCGATGTGCCACAAAAACTGCAAAATAAAGAAGTTATTCGTCTTGA
CGTGGTTTCTCTTGTTCAAGGAACAGGAATTCGTGGACAATTTGAAGAACGGATGCAAAAATTAATGGATGAAATCAGAA
AACGTAATGATGTCATTATGTTTATTGATGAAATTCATGAAATTGTCGGTGCTGGTTCTGCTGGCGACGGCAATATGGAT
GCAGGTAATATCCTAAAACCGGCTCTTGCACGTGGTGAGCTTCAATTGGTTGGAGCAACAACACTCAACGAATATCGTAT
TATTGAAAAAGATGCGGCACTTGAACGTCGGATGCAACCGGTCAAAGTAGATGAACCATCAGTTGATGAAACAATTACGA
TTTTGCGAGGCATTCAAGCACGTTATGAAGATTATCATCATGTGAAATACACTGATGAGGCTATTGAAGCAGCTGCTCAT
TTGTCAAATCGTTACATTCAAGACCGATTCTTACCAGATAAAGCCATCGACCTTTTAGATGAATCTGGTTCTAAGAAAAA
TCTGACTTTGAAATTTGTTGACCCTGAGGATATCAATCGTCGAATTGCTGATGCGGAAAGTAAGAAAAATGAAGCAACTA
AGGCTGAAGATTTTGAAAAAGCCGCTCATTTCCGTGACCAAATCAGTAAACTTCGTGAATTGCAAAAACAAGAAGTTACT
GACGAAGATATGCCAGTCATCACTGAAAAAGATATTGAACAAATTGTTGAACAAAAAACACAAATTCCAGTTGGGGATTT
GAAAGAAAAAGAACAAACTCAGTTGATTAATTTGGCTGATGATTTGAAAGCACATGTGATTGGTCAAGATGAAGCAGTAG
ATAAAATATCAAAAGCAATTCGTCGCTCACGTGTAGGTCTTGGCAAACCTAACCGTCCAATTGGTTCTTTCCTTTTTGTT
GGTCCAACAGGTGTAGGTAAAACCGAACTTGCTAAACAATTGGCTAAAGAATTATTTGGCTCAAGTGAGAGCATGATTCG
TTTTGATATGTCGGAATACATGGAAAAACATTCGGTGGCCAAATTGATTGGTGCGCCTCCAGGATATGTAGGTTATGAAG
AAGCGGGTCAATTGACCGAACGTGTTCGTCGTAATCCATACAGTTTGATTTTGCTTGATGAAATTGAAAAAGCTCATCCT
GATGTCATGCACATGTTCTTACAAATTCTTGAAGATGGCCGTCTGACAGATGCACAAGGACGGACAGTATCCTTCAAAGA
TAGTTTGATTATCATGACTTCAAATGCCGGAACTGGTAAAGTTGAAGCTTCTGTTGGATTTGGTGCAGCCCGCGAAGGAC
GAACTAAATCAGTGCTTGGTCAACTTGGTGATTTCTTTAGCCCTGAATTCATGAACCGTTTTGACGGAATTATTGAATTC
TCTGCTTTAAGCAAAGAAAATCTCCTTAAAATTGTTGATTTAATGCTTGATGAAGTCAATGAACAAATTGGACGTAATGA
TATTCATCTTAGTGTCACTCAAGCCGCTAAAGAAAAATTAGTGGACTTAGGATATAACCCTGCAATGGGTGCAAGACCTC
TTCGTAGAACAATTCAAGAAAATATTGAAGATTCAATTGCTGATTTCTACATTGAACATCCTGAATATAAACAATTGGTA
GCTGATTTGATTGATGATAAAATTGTCATTTCTAATCAAACCCAAGAAACAGCAGAAACCACTGATGAAGAAGTTCCTGC
CGAATAA

Domains

Predicted by InterproScan.

• AAA lid domain (AAA_lid_9) (287-386)

• AAA domain (Cdc48 subfamily) (AAA_2) (472-635)

• ATPase family associated with various cellular activities (AAA) (AAA) (149-268)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (643-713)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Lactococcus lactis subsp. cremoris KW2	99.866	100	0.999
clpE	Streptococcus mutans UA159	75.894	100	0.766
clpE	Streptococcus pneumoniae Rx1	75.815	98.396	0.746
clpE	Streptococcus pneumoniae D39	75.815	98.396	0.746
clpE	Streptococcus pneumoniae R6	75.815	98.396	0.746
clpE	Streptococcus pneumoniae TIGR4	75.815	98.396	0.746
clpC	Bacillus subtilis subsp. subtilis str. 168	48.664	95.053	0.463
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	47.023	87.567	0.412
clpC	Streptococcus pneumoniae Rx1	46.955	83.422	0.392
clpC	Streptococcus pneumoniae D39	46.955	83.422	0.392
clpC	Streptococcus pneumoniae TIGR4	46.955	83.422	0.392
clpC	Streptococcus thermophilus LMD-9	46.429	82.353	0.382
clpC	Streptococcus thermophilus LMG 18311	46.266	82.353	0.381
clpC	Streptococcus mutans UA159	45.631	82.62	0.377