Detailed information NTG0851342

Bioinformatically predicted

Overview

• Name: covS
• Type: Regulator
• Locus tag: LLUC029_RS04695
• Genome accession: NZ_CP129163
• Coordinates: 904869..906341 (+)
• Length: 490 a.a.
• NCBI ID: WP_032950293.1
• Uniprot ID: A0A1V0PFR7
• Organism: Lactococcus cremoris strain UC029
• Function: repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 899869..911341

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LLUC029_RS04665 (LLUC029_04670)	-	900312..901160 (+)	849	WP_396425099.1	CHAP domain-containing protein	-
LLUC029_RS04670 (LLUC029_04675)	-	901397..901759 (+)	363	Protein_909	TIGR02328 family protein	-
LLUC029_RS04675 (LLUC029_04680)	-	902083..902328 (+)	246	WP_011676633.1	type B 50S ribosomal protein L31	-
LLUC029_RS04680 (LLUC029_04685)	-	902433..903323 (-)	891	WP_308781426.1	IS982 family transposase	-
LLUC029_RS04685 (LLUC029_04690)	-	903477..904007 (+)	531	WP_011834860.1	DUF177 domain-containing protein	-
LLUC029_RS04690 (LLUC029_04695)	covR	904164..904856 (+)	693	WP_011676631.1	response regulator transcription factor	Regulator
LLUC029_RS04695 (LLUC029_04700)	covS	904869..906341 (+)	1473	WP_032950293.1	HAMP domain-containing histidine kinase	Regulator
LLUC029_RS04700 (LLUC029_04705)	-	906527..907768 (+)	1242	WP_015082643.1	ammonium transporter	-
LLUC029_RS04705 (LLUC029_04710)	-	907852..908193 (+)	342	WP_011676628.1	P-II family nitrogen regulator	-
LLUC029_RS04710 (LLUC029_04715)	murD	908362..909711 (+)	1350	WP_032950291.1	UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase	-
LLUC029_RS04715 (LLUC029_04720)	murG	909954..911027 (+)	1074	WP_011676626.1	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase	-

Sequence

Protein

• Length: 490 a.a.
• Molecular weight: 55890.81 Da
• Isoelectric Point: 4.7784

>NTDB_id=851342 LLUC029_RS04695 WP_032950293.1 904869..906341(+) (covS) [Lactococcus cremoris strain UC029]
MKKLFTFNKKKETVEESSAKRSIMLRWAFANTVFCFITFTLFATLTYQLTISSFIKEEQRLLTGSMDSVEEVLEQADAPL
NSTNLNTYIEATSKIQNGESEGMSLGSIIGTRKAFYIYDLNHKLLYSTNRRDFGFQKQGNNEMKEIQGENPGYLVQRKIV
SKGTGQVVGYLQAFYDTTTYHRISNLLLVVLLILEIVALIVAQMIGYFMANYFMKPLEKLYQGMQEMASDPTNDFKPIEI
ESGDEIEELAHVYNDMMLKMKAYLEQQNRFVSDVSHELRTPLAVLDGHINLLNRWGKNDPEVLDESLQASLDEVDRMKKM
LEEMLALARLENVDLSSEELDCDVGKVSNHALKNFQLLHEDFEIVLDNQLIYPVHARISENHFEQGLRILLDNAVKYSPD
DRKEIVITVSEDEQFVITSVSDKGIGIAKEDINHLFERFFRADKARNREIGGTGLGLPILARLAENYQGEIEVSSELGIG
STFTLKFPKI

Nucleotide

• Length: 1473 bp

>NTDB_id=851342 LLUC029_RS04695 WP_032950293.1 904869..906341(+) (covS) [Lactococcus cremoris strain UC029]
ATGAAAAAATTATTCACTTTCAACAAGAAAAAGGAAACGGTAGAAGAAAGTTCGGCTAAGCGGTCTATTATGCTTAGGTG
GGCTTTTGCTAACACCGTTTTTTGTTTTATTACTTTTACTCTTTTTGCAACATTAACTTATCAACTGACCATAAGTTCTT
TCATCAAGGAGGAACAAAGGTTATTGACAGGTTCAATGGACAGCGTTGAAGAGGTATTAGAACAAGCGGATGCTCCTTTA
AATTCAACTAATTTGAATACTTATATTGAAGCGACATCAAAGATTCAAAATGGGGAATCGGAAGGAATGAGTCTGGGAAG
TATCATCGGGACTCGGAAAGCATTTTATATTTATGATTTAAATCATAAATTACTATATTCAACTAATCGACGTGATTTTG
GATTTCAAAAGCAAGGCAATAATGAGATGAAAGAAATTCAAGGTGAGAATCCAGGTTATTTAGTCCAAAGGAAGATTGTT
TCTAAAGGGACGGGACAGGTTGTAGGCTATTTACAGGCATTTTATGACACGACAACTTATCATCGGATTTCCAATCTCCT
TTTAGTCGTCTTGTTAATTTTAGAAATTGTCGCTTTAATCGTTGCGCAAATGATTGGTTATTTTATGGCGAATTATTTTA
TGAAGCCTTTAGAAAAACTTTATCAGGGAATGCAGGAAATGGCGAGCGACCCCACGAATGATTTCAAACCTATCGAAATT
GAAAGTGGTGATGAAATTGAAGAATTAGCTCATGTTTATAATGATATGATGCTGAAAATGAAAGCATACCTTGAACAGCA
AAATCGGTTTGTCTCTGATGTTTCACATGAATTAAGGACTCCGTTAGCAGTTTTGGACGGTCATATTAATCTCTTAAATC
GTTGGGGAAAAAATGATCCAGAAGTTTTGGATGAATCTTTGCAGGCGAGTTTGGATGAAGTAGACCGAATGAAGAAAATG
CTTGAAGAAATGCTTGCTTTGGCTAGGCTTGAAAATGTAGATTTGTCCAGTGAAGAATTGGATTGTGACGTTGGGAAAGT
ATCTAATCATGCGCTTAAAAACTTCCAACTTCTACATGAGGATTTTGAGATTGTACTTGATAATCAGCTTATCTACCCTG
TCCATGCCCGGATATCTGAAAATCATTTTGAACAAGGATTACGCATTTTGTTAGATAATGCTGTTAAGTATTCTCCGGAT
GATCGAAAGGAGATTGTGATTACTGTTTCAGAAGATGAACAGTTTGTCATTACTAGTGTTTCTGATAAAGGAATCGGAAT
TGCCAAAGAAGATATTAATCATCTTTTTGAGCGATTCTTTCGAGCGGATAAGGCACGTAACCGTGAGATTGGCGGAACTG
GTTTAGGTTTACCAATTCTGGCTCGTTTAGCCGAAAATTATCAAGGAGAGATTGAAGTTAGTTCTGAGCTTGGGATTGGT
TCAACTTTTACCTTAAAATTTCCAAAAATATGA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (380-488)

• His Kinase A (phospho-acceptor) domain (HisKA) (267-332)

• HAMP domain (HAMP) (208-258)

• ArlS sensor domain (ArlS_N) (54-185)

3D structure

• AlphaFold DB: A0A1V0PFR7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
covS	Lactococcus lactis subsp. lactis strain DGCC12653	94.49	100	0.945