Detailed information
Bioinformatically predicted
Overview
| Name | clpC | Type | Regulator |
| Locus tag | LLA22_RS02875 | Genome accession | NZ_CP128421 |
| Coordinates | 554461..556707 (+) | Length | 748 a.a. |
| NCBI ID | WP_015082116.1 | Uniprot ID | - |
| Organism | Lactococcus cremoris strain A.2.2 | ||
| Function | degradation of ComX (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 556439..594685 | 554461..556707 | flank | -268 |
Gene organization within MGE regions
Location: 554461..594685
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LLA22_RS02875 (LLA22_02870) | clpC | 554461..556707 (+) | 2247 | WP_015082116.1 | ATP-dependent Clp protease ATP-binding subunit | Regulator |
| LLA22_RS02880 (LLA22_02875) | - | 556833..557303 (-) | 471 | WP_015082117.1 | Rrf2 family transcriptional regulator | - |
| LLA22_RS02885 (LLA22_02880) | gap | 557529..558542 (+) | 1014 | Protein_540 | type I glyceraldehyde-3-phosphate dehydrogenase | - |
| LLA22_RS02890 (LLA22_02885) | def | 558766..559401 (-) | 636 | WP_011675571.1 | peptide deformylase | - |
| LLA22_RS02895 (LLA22_02890) | - | 559556..559960 (+) | 405 | WP_015082118.1 | RNA pyrophosphohydrolase | - |
| LLA22_RS02900 (LLA22_02895) | uvrB | 560022..562100 (+) | 2079 | WP_011675573.1 | excinuclease ABC subunit UvrB | - |
| LLA22_RS02905 (LLA22_02900) | - | 562282..562758 (+) | 477 | WP_041931868.1 | transporter substrate-binding domain-containing protein | - |
| LLA22_RS02915 (LLA22_02910) | - | 564225..564590 (+) | 366 | WP_021213719.1 | transporter substrate-binding domain-containing protein | - |
| LLA22_RS02920 (LLA22_02915) | - | 564605..565144 (+) | 540 | WP_228763946.1 | M20 family metallopeptidase | - |
| LLA22_RS02925 (LLA22_02920) | - | 565141..565371 (+) | 231 | Protein_548 | peptidase dimerization domain-containing protein | - |
| LLA22_RS02930 (LLA22_02925) | - | 565590..565724 (+) | 135 | WP_231097943.1 | hypothetical protein | - |
| LLA22_RS02935 (LLA22_02930) | fabZ | 565776..566231 (-) | 456 | WP_011675575.1 | 3-hydroxyacyl-ACP dehydratase FabZ | - |
| LLA22_RS02940 (LLA22_02935) | fabI | 566507..567259 (+) | 753 | WP_015082121.1 | enoyl-ACP reductase FabI | - |
| LLA22_RS02945 (LLA22_02940) | yidC | 567445..568407 (-) | 963 | WP_015082122.1 | membrane protein insertase YidC | - |
| LLA22_RS02950 (LLA22_02945) | - | 568582..569340 (-) | 759 | WP_011675578.1 | HAD-IIB family hydrolase | - |
| LLA22_RS02955 (LLA22_02950) | - | 569435..570025 (-) | 591 | WP_011675579.1 | ECF transporter S component | - |
| LLA22_RS02960 (LLA22_02955) | coaC | 570042..570578 (-) | 537 | WP_014573068.1 | phosphopantothenoylcysteine decarboxylase | - |
| LLA22_RS02965 (LLA22_02960) | - | 570571..571266 (-) | 696 | WP_011675580.1 | phosphopantothenate--cysteine ligase | - |
| LLA22_RS02970 (LLA22_02965) | - | 571376..571597 (-) | 222 | WP_015082124.1 | 2-hydroxymuconate tautomerase | - |
| LLA22_RS02975 (LLA22_02970) | - | 571783..574110 (+) | 2328 | Protein_558 | cation-translocating P-type ATPase | - |
| LLA22_RS02980 (LLA22_02980) | - | 574143..574337 (+) | 195 | WP_051013160.1 | hypothetical protein | - |
| LLA22_RS02985 (LLA22_02985) | - | 574358..575469 (+) | 1112 | WP_127005270.1 | IS3-like element IS981 family transposase | - |
| LLA22_RS02990 (LLA22_02990) | - | 575784..576128 (+) | 345 | WP_014573064.1 | hypothetical protein | - |
| LLA22_RS02995 (LLA22_02995) | - | 576206..576988 (+) | 783 | WP_014573063.1 | hypothetical protein | - |
| LLA22_RS03000 (LLA22_03000) | - | 577195..577512 (+) | 318 | WP_014573062.1 | hypothetical protein | - |
| LLA22_RS03005 (LLA22_03005) | - | 577512..578546 (+) | 1035 | Protein_564 | cell division protein FtsK | - |
| LLA22_RS03010 (LLA22_03010) | - | 578705..579748 (+) | 1044 | WP_011675590.1 | hypothetical protein | - |
| LLA22_RS03015 (LLA22_03015) | - | 579754..579963 (+) | 210 | WP_014573057.1 | hypothetical protein | - |
| LLA22_RS03020 (LLA22_03020) | - | 580023..581147 (+) | 1125 | WP_015082126.1 | site-specific integrase | - |
| LLA22_RS03025 (LLA22_03025) | - | 581317..581886 (+) | 570 | WP_011675593.1 | thymidine kinase | - |
| LLA22_RS03030 (LLA22_03030) | - | 581897..582340 (+) | 444 | WP_011675594.1 | hypothetical protein | - |
| LLA22_RS03035 (LLA22_03035) | prfA | 582358..583431 (+) | 1074 | WP_011675595.1 | peptide chain release factor 1 | - |
| LLA22_RS03040 (LLA22_03040) | - | 583431..583958 (+) | 528 | WP_015082127.1 | hypothetical protein | - |
| LLA22_RS03045 (LLA22_03045) | nfsA | 584028..584783 (+) | 756 | WP_011675598.1 | oxygen-insensitive NADPH nitroreductase | - |
| LLA22_RS03050 (LLA22_03050) | prmC | 584888..585703 (+) | 816 | WP_015082128.1 | peptide chain release factor N(5)-glutamine methyltransferase | - |
| LLA22_RS03055 (LLA22_03055) | - | 585734..586198 (+) | 465 | WP_011675600.1 | GNAT family N-acetyltransferase | - |
| LLA22_RS03060 (LLA22_03060) | - | 586222..587115 (+) | 894 | WP_257590455.1 | L-threonylcarbamoyladenylate synthase | - |
| LLA22_RS03065 (LLA22_03065) | glyA | 587348..588595 (+) | 1248 | WP_015082129.1 | serine hydroxymethyltransferase | - |
| LLA22_RS03070 (LLA22_03070) | - | 588776..589378 (+) | 603 | WP_015082130.1 | lysozyme family protein | - |
| LLA22_RS03075 (LLA22_03075) | serC | 589505..590602 (+) | 1098 | WP_015082131.1 | 3-phosphoserine/phosphohydroxythreonine transaminase | - |
| LLA22_RS03080 (LLA22_03080) | - | 590599..591795 (+) | 1197 | WP_015082132.1 | 3-phosphoglycerate dehydrogenase family protein | - |
| LLA22_RS03085 (LLA22_03085) | serB | 591841..592503 (+) | 663 | WP_011675606.1 | phosphoserine phosphatase SerB | - |
| LLA22_RS03090 (LLA22_03090) | - | 592546..592833 (-) | 288 | Protein_581 | acylphosphatase | - |
| LLA22_RS03095 (LLA22_03095) | - | 592945..593703 (+) | 759 | WP_015082133.1 | RNA methyltransferase | - |
| LLA22_RS03100 (LLA22_03100) | - | 593915..594304 (-) | 390 | WP_015082134.1 | cupin domain-containing protein | - |
| LLA22_RS03105 (LLA22_03105) | - | 594304..594531 (-) | 228 | WP_011675745.1 | hypothetical protein | - |
Sequence
Protein
Download Length: 748 a.a. Molecular weight: 83252.03 Da Isoelectric Point: 4.7362
>NTDB_id=847414 LLA22_RS02875 WP_015082116.1 554461..556707(+) (clpC) [Lactococcus cremoris strain A.2.2]
MLCQNCNINEATIHLYTSVNGQKKQIDLCQNCYQIMKSGGQEALFGAGNASNGNSDEPFNPFNDIFSALQGQDFNGAASN
QTPPTQTGGRGPRGPQNPRAKQPKGMLEEFGINITESARRGEIDPVIGRDEEIKRVIEILNRRTKNNPVLIGEPGVGKTA
VVEGLAQKIVDDDVPQKLQNKEVIRLDVVSLVQGTGIRGQFEERMQKLMDEIRKRNDVIMFIDEIHEIVGAGSAGDGNMD
AGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVDETITILRGIQARYEDYHHVKYTDEAIEAAAH
LSNRYIQDRFLPDKAIDLLDESGSKKNLTLKFVDPEDINRRIADAESKKNEATKAEDFEKAAHFRDQISKLRELQKQEVT
DEDMPVITEKDIEQIVEQKTQIPVGDLKEKEQTQLINLADDLKAHVIGQDEAVDKISKAIRRSRVGLGKPNRPIGSFLFV
GPTGVGKTELAKQLAKELFGSSESMIRFDMSEYMEKHSVAKLIGAPPGYVGYEEAGQLTERVRRNPYSLILLDEIEKAHP
DVMHMFLQILEDGRLTDAQGRTVSFKDSLIIMTSNAGTGKVEASVGFGAAREGRTKSVLGQLGDFFSPEFMNRFDGIIEF
SALSKENLLKIVDLMLDEVNEQIGRNDIHLSVTQAAKEKLVDLGYNPAMGARPLRRTIQENIEDSIADFYIEHPEYKQLV
ADLIDDKIVISNQTQETAETTDEEVPAE
MLCQNCNINEATIHLYTSVNGQKKQIDLCQNCYQIMKSGGQEALFGAGNASNGNSDEPFNPFNDIFSALQGQDFNGAASN
QTPPTQTGGRGPRGPQNPRAKQPKGMLEEFGINITESARRGEIDPVIGRDEEIKRVIEILNRRTKNNPVLIGEPGVGKTA
VVEGLAQKIVDDDVPQKLQNKEVIRLDVVSLVQGTGIRGQFEERMQKLMDEIRKRNDVIMFIDEIHEIVGAGSAGDGNMD
AGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVDETITILRGIQARYEDYHHVKYTDEAIEAAAH
LSNRYIQDRFLPDKAIDLLDESGSKKNLTLKFVDPEDINRRIADAESKKNEATKAEDFEKAAHFRDQISKLRELQKQEVT
DEDMPVITEKDIEQIVEQKTQIPVGDLKEKEQTQLINLADDLKAHVIGQDEAVDKISKAIRRSRVGLGKPNRPIGSFLFV
GPTGVGKTELAKQLAKELFGSSESMIRFDMSEYMEKHSVAKLIGAPPGYVGYEEAGQLTERVRRNPYSLILLDEIEKAHP
DVMHMFLQILEDGRLTDAQGRTVSFKDSLIIMTSNAGTGKVEASVGFGAAREGRTKSVLGQLGDFFSPEFMNRFDGIIEF
SALSKENLLKIVDLMLDEVNEQIGRNDIHLSVTQAAKEKLVDLGYNPAMGARPLRRTIQENIEDSIADFYIEHPEYKQLV
ADLIDDKIVISNQTQETAETTDEEVPAE
Nucleotide
Download Length: 2247 bp
>NTDB_id=847414 LLA22_RS02875 WP_015082116.1 554461..556707(+) (clpC) [Lactococcus cremoris strain A.2.2]
ATGCTTTGTCAAAATTGTAATATTAATGAAGCGACGATTCACCTTTACACAAGTGTAAATGGTCAGAAAAAACAAATTGA
TTTGTGCCAAAACTGTTATCAAATTATGAAATCTGGTGGTCAAGAAGCTTTATTTGGCGCAGGAAATGCCTCAAATGGAA
ATTCTGATGAACCCTTTAATCCGTTTAACGATATCTTCAGTGCTTTGCAAGGTCAAGATTTTAATGGGGCAGCAAGTAAT
CAAACTCCCCCAACACAAACGGGTGGGCGTGGTCCGCGTGGTCCACAAAATCCTCGGGCAAAACAACCTAAAGGGATGCT
AGAAGAATTCGGTATTAATATCACCGAATCAGCTCGTCGTGGCGAAATTGACCCAGTGATTGGGCGTGATGAAGAAATCA
AACGTGTTATTGAGATTTTAAATCGCAGAACTAAGAATAATCCAGTGCTAATTGGTGAACCTGGTGTTGGTAAAACAGCA
GTTGTTGAAGGTTTAGCACAAAAAATAGTCGATGACGATGTGCCACAAAAACTGCAAAATAAAGAAGTTATTCGTCTTGA
CGTGGTTTCTCTTGTTCAAGGAACAGGAATTCGTGGACAATTTGAAGAACGGATGCAAAAATTAATGGATGAAATCAGAA
AACGTAATGATGTCATTATGTTTATTGATGAAATTCATGAAATTGTCGGTGCTGGTTCTGCTGGCGACGGCAATATGGAT
GCAGGTAATATCCTAAAACCGGCTCTTGCACGTGGTGAGCTTCAATTGGTTGGAGCAACAACACTCAACGAATATCGTAT
TATTGAAAAAGATGCGGCACTTGAACGTCGGATGCAACCGGTCAAAGTAGATGAACCATCAGTTGATGAAACAATTACGA
TTTTGCGAGGCATTCAAGCACGTTATGAAGATTATCATCATGTGAAATACACTGATGAGGCTATTGAAGCAGCTGCTCAT
TTGTCAAATCGTTACATTCAAGACCGATTCTTACCAGATAAAGCCATCGACCTTTTAGATGAATCTGGTTCTAAGAAAAA
TCTGACTTTGAAATTTGTTGACCCTGAGGATATCAATCGTCGAATTGCTGATGCGGAAAGTAAGAAAAATGAAGCAACTA
AGGCTGAAGATTTTGAAAAAGCCGCTCATTTCCGTGACCAAATCAGTAAACTTCGTGAATTGCAAAAACAAGAAGTTACT
GACGAAGATATGCCAGTCATCACTGAAAAAGATATTGAACAAATTGTTGAACAAAAAACACAAATTCCAGTTGGGGATTT
GAAAGAAAAAGAACAAACTCAGTTGATTAATTTGGCTGATGATTTGAAAGCACATGTGATTGGTCAAGATGAAGCAGTAG
ATAAAATATCAAAAGCAATTCGTCGCTCACGTGTAGGTCTTGGCAAACCTAACCGTCCAATTGGTTCTTTCCTTTTTGTT
GGTCCAACAGGTGTAGGTAAAACCGAACTTGCTAAACAATTGGCTAAAGAATTATTTGGCTCAAGTGAGAGCATGATTCG
TTTTGATATGTCGGAATACATGGAAAAACATTCGGTGGCCAAATTGATTGGTGCGCCTCCAGGATATGTAGGTTATGAAG
AAGCGGGTCAATTGACCGAACGTGTTCGTCGTAATCCATACAGTTTGATTTTGCTTGATGAAATTGAAAAAGCTCATCCT
GATGTCATGCACATGTTCTTACAAATTCTTGAAGATGGCCGTCTGACAGATGCACAAGGACGGACAGTATCCTTCAAAGA
TAGTTTGATTATCATGACTTCAAATGCCGGAACTGGTAAAGTTGAAGCTTCTGTTGGATTTGGTGCAGCCCGCGAAGGAC
GAACTAAATCAGTGCTTGGTCAACTTGGTGATTTCTTTAGCCCTGAATTCATGAACCGTTTTGACGGAATTATTGAATTC
TCTGCTTTAAGCAAAGAAAATCTCCTTAAAATTGTTGATTTAATGCTTGATGAAGTCAATGAACAAATTGGACGTAATGA
TATTCATCTTAGTGTCACTCAAGCCGCTAAAGAAAAATTAGTGGACTTAGGATATAACCCTGCAATGGGTGCAAGACCTC
TTCGTAGAACAATTCAAGAAAATATTGAAGATTCAATTGCTGATTTCTACATTGAACATCCTGAATATAAACAATTGGTA
GCTGATTTGATTGATGATAAAATTGTCATTTCTAATCAAACCCAAGAAACAGCAGAAACCACTGATGAAGAAGTTCCTGC
CGAATAA
ATGCTTTGTCAAAATTGTAATATTAATGAAGCGACGATTCACCTTTACACAAGTGTAAATGGTCAGAAAAAACAAATTGA
TTTGTGCCAAAACTGTTATCAAATTATGAAATCTGGTGGTCAAGAAGCTTTATTTGGCGCAGGAAATGCCTCAAATGGAA
ATTCTGATGAACCCTTTAATCCGTTTAACGATATCTTCAGTGCTTTGCAAGGTCAAGATTTTAATGGGGCAGCAAGTAAT
CAAACTCCCCCAACACAAACGGGTGGGCGTGGTCCGCGTGGTCCACAAAATCCTCGGGCAAAACAACCTAAAGGGATGCT
AGAAGAATTCGGTATTAATATCACCGAATCAGCTCGTCGTGGCGAAATTGACCCAGTGATTGGGCGTGATGAAGAAATCA
AACGTGTTATTGAGATTTTAAATCGCAGAACTAAGAATAATCCAGTGCTAATTGGTGAACCTGGTGTTGGTAAAACAGCA
GTTGTTGAAGGTTTAGCACAAAAAATAGTCGATGACGATGTGCCACAAAAACTGCAAAATAAAGAAGTTATTCGTCTTGA
CGTGGTTTCTCTTGTTCAAGGAACAGGAATTCGTGGACAATTTGAAGAACGGATGCAAAAATTAATGGATGAAATCAGAA
AACGTAATGATGTCATTATGTTTATTGATGAAATTCATGAAATTGTCGGTGCTGGTTCTGCTGGCGACGGCAATATGGAT
GCAGGTAATATCCTAAAACCGGCTCTTGCACGTGGTGAGCTTCAATTGGTTGGAGCAACAACACTCAACGAATATCGTAT
TATTGAAAAAGATGCGGCACTTGAACGTCGGATGCAACCGGTCAAAGTAGATGAACCATCAGTTGATGAAACAATTACGA
TTTTGCGAGGCATTCAAGCACGTTATGAAGATTATCATCATGTGAAATACACTGATGAGGCTATTGAAGCAGCTGCTCAT
TTGTCAAATCGTTACATTCAAGACCGATTCTTACCAGATAAAGCCATCGACCTTTTAGATGAATCTGGTTCTAAGAAAAA
TCTGACTTTGAAATTTGTTGACCCTGAGGATATCAATCGTCGAATTGCTGATGCGGAAAGTAAGAAAAATGAAGCAACTA
AGGCTGAAGATTTTGAAAAAGCCGCTCATTTCCGTGACCAAATCAGTAAACTTCGTGAATTGCAAAAACAAGAAGTTACT
GACGAAGATATGCCAGTCATCACTGAAAAAGATATTGAACAAATTGTTGAACAAAAAACACAAATTCCAGTTGGGGATTT
GAAAGAAAAAGAACAAACTCAGTTGATTAATTTGGCTGATGATTTGAAAGCACATGTGATTGGTCAAGATGAAGCAGTAG
ATAAAATATCAAAAGCAATTCGTCGCTCACGTGTAGGTCTTGGCAAACCTAACCGTCCAATTGGTTCTTTCCTTTTTGTT
GGTCCAACAGGTGTAGGTAAAACCGAACTTGCTAAACAATTGGCTAAAGAATTATTTGGCTCAAGTGAGAGCATGATTCG
TTTTGATATGTCGGAATACATGGAAAAACATTCGGTGGCCAAATTGATTGGTGCGCCTCCAGGATATGTAGGTTATGAAG
AAGCGGGTCAATTGACCGAACGTGTTCGTCGTAATCCATACAGTTTGATTTTGCTTGATGAAATTGAAAAAGCTCATCCT
GATGTCATGCACATGTTCTTACAAATTCTTGAAGATGGCCGTCTGACAGATGCACAAGGACGGACAGTATCCTTCAAAGA
TAGTTTGATTATCATGACTTCAAATGCCGGAACTGGTAAAGTTGAAGCTTCTGTTGGATTTGGTGCAGCCCGCGAAGGAC
GAACTAAATCAGTGCTTGGTCAACTTGGTGATTTCTTTAGCCCTGAATTCATGAACCGTTTTGACGGAATTATTGAATTC
TCTGCTTTAAGCAAAGAAAATCTCCTTAAAATTGTTGATTTAATGCTTGATGAAGTCAATGAACAAATTGGACGTAATGA
TATTCATCTTAGTGTCACTCAAGCCGCTAAAGAAAAATTAGTGGACTTAGGATATAACCCTGCAATGGGTGCAAGACCTC
TTCGTAGAACAATTCAAGAAAATATTGAAGATTCAATTGCTGATTTCTACATTGAACATCCTGAATATAAACAATTGGTA
GCTGATTTGATTGATGATAAAATTGTCATTTCTAATCAAACCCAAGAAACAGCAGAAACCACTGATGAAGAAGTTCCTGC
CGAATAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| clpC | Lactococcus lactis subsp. cremoris KW2 |
99.733 |
100 |
0.997 |
| clpE | Streptococcus mutans UA159 |
75.762 |
100 |
0.765 |
| clpE | Streptococcus pneumoniae Rx1 |
75.679 |
98.396 |
0.745 |
| clpE | Streptococcus pneumoniae D39 |
75.679 |
98.396 |
0.745 |
| clpE | Streptococcus pneumoniae R6 |
75.679 |
98.396 |
0.745 |
| clpE | Streptococcus pneumoniae TIGR4 |
75.679 |
98.396 |
0.745 |
| clpC | Bacillus subtilis subsp. subtilis str. 168 |
48.664 |
95.053 |
0.463 |
| clpC | Lactococcus lactis subsp. lactis strain DGCC12653 |
46.87 |
87.567 |
0.41 |
| clpC | Streptococcus pneumoniae Rx1 |
46.795 |
83.422 |
0.39 |
| clpC | Streptococcus pneumoniae D39 |
46.795 |
83.422 |
0.39 |
| clpC | Streptococcus pneumoniae TIGR4 |
46.795 |
83.422 |
0.39 |
| clpC | Streptococcus thermophilus LMD-9 |
46.266 |
82.353 |
0.381 |
| clpC | Streptococcus thermophilus LMG 18311 |
46.104 |
82.353 |
0.38 |
| clpC | Streptococcus mutans UA159 |
45.631 |
82.62 |
0.377 |