Detailed information NTG0847396

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: V4942_RS05745
• Genome accession: NZ_CP144687
• Coordinates: 1090905..1093469 (-)
• Length: 854 a.a.
• NCBI ID: WP_011173537.1
• Uniprot ID: Q72IK9
• Organism: Thermus thermophilus strain TTHB27_delta_cmr4
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 1085905..1098469

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
V4942_RS05705 (V4942_05705)	-	1086261..1086707 (-)	447	WP_011173529.1	DUF1931 family protein	-
V4942_RS05710 (V4942_05710)	-	1086775..1087188 (-)	414	WP_011173530.1	Hsp20/alpha crystallin family protein	-
V4942_RS05715 (V4942_05715)	trxA	1087192..1087614 (-)	423	WP_011173531.1	thioredoxin	-
V4942_RS05720 (V4942_05720)	-	1087677..1088105 (-)	429	WP_011173532.1	ferritin-like domain-containing protein	-
V4942_RS05725 (V4942_05725)	-	1088197..1088883 (-)	687	WP_011173533.1	heat-stable protein	-
V4942_RS05730 (V4942_05730)	-	1088896..1089309 (-)	414	WP_011173534.1	Hsp20/alpha crystallin family protein	-
V4942_RS05735 (V4942_05735)	-	1089325..1090509 (-)	1185	WP_011173535.1	VLRF1 family aeRF1-type release factor	-
V4942_RS05740 (V4942_05740)	-	1090506..1090895 (-)	390	WP_011173536.1	ferritin family protein	-
V4942_RS05745 (V4942_05745)	clpC	1090905..1093469 (-)	2565	WP_011173537.1	ATP-dependent chaperone ClpB	Regulator
V4942_RS05750 (V4942_05750)	-	1093621..1093857 (-)	237	WP_011173538.1	chaperone modulator CbpM	-
V4942_RS05755 (V4942_05755)	dnaJ2	1093844..1094686 (-)	843	WP_011173539.1	molecular chaperone DnaJ2	-
V4942_RS05760 (V4942_05760)	gprE	1094690..1095223 (-)	534	WP_011173540.1	nucleotide exchange factor GrpE	-
V4942_RS05765 (V4942_05765)	dnaK	1095279..1097126 (-)	1848	WP_011173541.1	molecular chaperone DnaK	-

Sequence

Protein

• Length: 854 a.a.
• Molecular weight: 96140.52 Da
• Isoelectric Point: 5.4970

>NTDB_id=847396 V4942_RS05745 WP_011173537.1 1090905..1093469(-) (clpC) [Thermus thermophilus strain TTHB27_delta_cmr4]
MNLERWTQAAREALAQAQVLAQRMKHQAIDLPHLWAVLLKDEGGLAWRLLEKAGADPKALKELQERELSRLPKVEGAEVG
QYLTSRLSGALNRAEALMEELKDRYVAVDTLVLALAEATPGLPGLEALKGALKELRGGRTVQTEHAESTYNALEQYGIDL
TRLAAEGKLDPVIGRDEEIRRVIQILLRRTKNNPVLIGEPGVGKTAIVEGLAQRIVKGDVPEGLKGKRIVSLQMGSLLAG
AKYRGEFEERLKAVIQEVVQSQGEVILFIDELHTVVGAGKAEGAVDAGNMLKPALARGELRLIGATTLDEYREIEKDPAL
ERRFQPVYVDEPTVEETISILRGLKEKYEVHHGVRISDSAIIAAATLSHRYITERRLPDKAIDLIDEAAARLRMALESAP
EEIDALERKKLQLEIEREALKKEKDPDSQERLKAIEAEIAKLTEEIAKLRAEWEREREILRKLREAQHRLDEVRREIELA
ERQYDLNRAAELRYGELPKLEAEVEALSEKLRGARFVRLEVTEEDIAEIVSRWTGIPVSKLLEGEREKLLRLEEELHKRV
VGQDEAIRAVADAIRRARAGLKDPNRPIGSFLFLGPTGVGKTELAKTLAATLFDTEEAMIRIDMTEYMEKHAVSRLIGAP
PGYVGYEEGGQLTEAVRRRPYSVILFDEIEKAHPDVFNILLQILDDGRLTDSHGRTVDFRNTVIILTSNLGSPLILEGLQ
KGWPYERIRDEVFKVLQQHFRPEFLNRLDEIVVFRPLTKEQIRQIVEIQLSYLRARLAEKRISLELTEAAKDFLAERGYD
PVFGARPLRRVIQRELETPLAQKILAGEVKEGDRVQVDVGPAGLVFAVPARVEA

Nucleotide

• Length: 2565 bp

>NTDB_id=847396 V4942_RS05745 WP_011173537.1 1090905..1093469(-) (clpC) [Thermus thermophilus strain TTHB27_delta_cmr4]
ATGAACCTGGAACGCTGGACCCAAGCCGCCCGCGAAGCCCTGGCCCAGGCGCAGGTCCTGGCGCAAAGGATGAAGCACCA
GGCCATAGACCTGCCCCACCTCTGGGCTGTCCTCCTGAAGGACGAGGGGGGCCTCGCCTGGCGCCTCTTGGAGAAGGCGG
GGGCCGACCCCAAGGCCCTTAAAGAGCTCCAGGAGCGGGAGCTTTCCCGCCTGCCCAAGGTGGAAGGGGCCGAGGTGGGC
CAGTACCTCACGAGCCGCCTCTCCGGGGCCTTGAACCGGGCCGAGGCCCTGATGGAGGAGCTCAAGGACCGCTACGTGGC
GGTGGACACCCTGGTCCTGGCCTTGGCGGAGGCCACGCCGGGGCTTCCGGGCCTGGAGGCCCTGAAGGGGGCGCTCAAGG
AACTGAGGGGAGGGAGAACCGTGCAGACGGAACACGCGGAAAGCACCTACAACGCTTTGGAGCAGTACGGCATTGACCTC
ACGCGGCTTGCCGCCGAGGGGAAGCTGGACCCCGTGATCGGCCGGGACGAGGAGATCCGGCGGGTGATCCAGATCCTCCT
CCGGCGCACCAAGAACAACCCGGTGCTCATCGGCGAGCCCGGCGTGGGGAAGACGGCCATCGTGGAGGGCCTGGCCCAGC
GCATCGTCAAGGGGGACGTGCCCGAAGGCCTCAAGGGCAAGCGGATCGTCTCCTTGCAGATGGGCTCCCTCCTCGCCGGG
GCCAAGTACCGGGGCGAGTTTGAGGAGCGCTTGAAGGCGGTGATCCAGGAGGTGGTCCAGTCCCAAGGGGAAGTCATCCT
CTTCATTGACGAGCTCCACACCGTGGTGGGGGCGGGCAAGGCCGAGGGCGCCGTGGACGCGGGCAACATGCTGAAGCCCG
CCCTGGCCCGGGGGGAGCTCAGGCTCATCGGGGCCACCACCCTGGACGAGTACCGGGAGATTGAGAAGGACCCCGCCCTG
GAGCGCCGCTTCCAGCCCGTGTACGTGGACGAGCCCACGGTGGAGGAGACCATCTCTATCCTCCGGGGCCTCAAGGAGAA
GTACGAGGTCCACCACGGGGTGCGCATCTCCGACAGCGCCATCATCGCCGCCGCCACCCTCTCCCACCGGTACATCACGG
AAAGGCGCCTTCCCGACAAGGCCATTGACCTCATTGACGAGGCGGCGGCCCGCCTGCGCATGGCCCTGGAGAGCGCTCCC
GAGGAGATTGACGCCCTGGAGCGCAAGAAGCTCCAGCTGGAGATTGAGCGGGAGGCCCTGAAGAAGGAGAAGGACCCGGA
CTCCCAGGAGCGCCTCAAGGCCATTGAGGCCGAGATCGCCAAGCTCACGGAGGAGATCGCCAAGCTCCGGGCCGAGTGGG
AGAGGGAGCGGGAGATCCTGAGGAAGCTCCGCGAGGCCCAGCACCGCCTGGACGAGGTCAGGCGGGAGATTGAGCTCGCC
GAGCGGCAGTACGACCTGAACCGGGCCGCCGAGCTCCGCTACGGGGAGCTTCCCAAGCTGGAGGCCGAGGTGGAGGCCCT
TTCGGAAAAGCTCCGGGGCGCCCGCTTCGTCCGCCTCGAGGTCACCGAGGAGGACATCGCCGAGATCGTCTCCCGCTGGA
CCGGGATCCCTGTGTCCAAGCTCCTGGAAGGGGAGAGGGAGAAGCTTTTGAGGCTTGAGGAGGAGCTCCACAAGCGGGTG
GTGGGGCAGGACGAGGCCATAAGGGCCGTGGCCGACGCCATCCGCCGGGCGAGGGCCGGCCTAAAGGACCCGAACCGGCC
CATCGGAAGCTTCCTCTTCCTCGGGCCCACGGGGGTGGGGAAGACGGAGCTCGCCAAGACCCTGGCCGCCACCCTCTTTG
ACACCGAGGAGGCCATGATCCGCATTGACATGACGGAGTACATGGAGAAGCACGCCGTCTCCCGCCTCATCGGGGCCCCG
CCCGGCTACGTGGGCTACGAGGAGGGGGGCCAGCTCACCGAGGCGGTGCGGAGGAGGCCCTACTCGGTCATCCTCTTTGA
CGAGATTGAGAAGGCCCACCCCGACGTCTTCAACATCCTCCTCCAGATCCTGGACGACGGCCGCCTCACCGACAGCCACG
GCCGCACCGTGGACTTCCGCAACACCGTCATCATCCTCACCTCCAACCTGGGGAGCCCCTTGATCCTCGAGGGCCTCCAG
AAGGGCTGGCCCTACGAGAGGATCCGGGACGAGGTCTTTAAGGTCTTGCAGCAGCACTTCCGCCCCGAGTTCCTGAACCG
CCTGGACGAGATCGTGGTCTTCCGGCCCCTCACCAAGGAGCAGATCCGCCAGATCGTGGAGATCCAGCTCTCCTACCTCC
GGGCCCGCCTCGCCGAGAAGCGCATCTCCCTGGAGCTCACCGAGGCCGCCAAGGACTTCCTGGCGGAAAGGGGCTACGAC
CCCGTCTTCGGGGCAAGGCCCTTGCGGCGGGTCATCCAGCGGGAGCTGGAGACGCCCCTCGCCCAGAAGATCCTGGCCGG
CGAGGTCAAGGAGGGGGACCGCGTGCAGGTGGACGTGGGGCCCGCGGGCCTCGTGTTTGCCGTCCCCGCCCGGGTGGAGG
CCTGA

Domains

Predicted by InterProScan.

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (757-837)

• AAA lid domain (AAA_lid_9) (333-435)

• ATPase family associated with various cellular activities (AAA) (AAA) (195-325)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (94-136)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (17-68)

• AAA domain (Cdc48 subfamily) (AAA_2) (586-751)

3D structure

• AlphaFold DB: Q72IK9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Bacillus subtilis subsp. subtilis str. 168	47.2	100	0.484
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	42.972	100	0.437
clpC	Lactococcus lactis subsp. cremoris KW2	49.054	80.445	0.395
clpE	Streptococcus pneumoniae TIGR4	48.547	80.562	0.391
clpE	Streptococcus pneumoniae Rx1	48.547	80.562	0.391
clpE	Streptococcus pneumoniae D39	48.547	80.562	0.391
clpE	Streptococcus pneumoniae R6	48.547	80.562	0.391
clpC	Streptococcus thermophilus LMG 18311	45.035	83.724	0.377
clpC	Streptococcus thermophilus LMD-9	44.46	83.489	0.371