NTDB

Overview

Name	uvrA	Type	Machinery gene
Locus tag	V4943_RS05495	Genome accession	NZ_CP144685
Coordinates	1044122..1046980 (+)	Length	952 a.a.
NCBI ID	WP_011173491.1	Uniprot ID	Q72IQ7
Organism	Thermus thermophilus strain HB27_delta_csm3
Function	homologous recombination (predicted from homology) Homologous recombination

Genomic Context

Location: 1039122..1051980

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
V4943_RS05465 (V4943_05465)	-	1039490..1040305 (-)	816	WP_011228679.1	enoyl-CoA hydratase-related protein	-
V4943_RS05470 (V4943_05470)	-	1040309..1041016 (-)	708	WP_011173486.1	purine-nucleoside phosphorylase	-
V4943_RS05475 (V4943_05475)	-	1041029..1041658 (-)	630	WP_011173487.1	ABC transporter ATP-binding protein	-
V4943_RS05480 (V4943_05480)	-	1041707..1042357 (+)	651	WP_011173488.1	Crp/Fnr family transcriptional regulator	-
V4943_RS05485 (V4943_05485)	-	1042367..1043080 (+)	714	WP_011173489.1	2-phosphosulfolactate phosphatase	-
V4943_RS05490 (V4943_05490)	-	1043132..1044046 (-)	915	WP_011173490.1	sugar aminotransferase	-
V4943_RS05495 (V4943_05495)	uvrA	1044122..1046980 (+)	2859	WP_011173491.1	excinuclease ABC subunit UvrA	Machinery gene
V4943_RS05500 (V4943_05500)	-	1047028..1048017 (-)	990	WP_011173492.1	TIGR00341 family protein	-
V4943_RS05505 (V4943_05505)	trmFO	1048019..1049350 (-)	1332	WP_011173493.1	methylenetetrahydrofolate--tRNA-(uracil(54)- C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO	-
V4943_RS05510 (V4943_05510)	-	1049397..1049696 (+)	300	WP_011173494.1	Uma2 family endonuclease	-
V4943_RS05515 (V4943_05515)	hisF	1049693..1050451 (+)	759	WP_011173495.1	imidazole glycerol phosphate synthase subunit HisF	-
V4943_RS05520 (V4943_05520)	hisIE	1050456..1051100 (+)	645	WP_011173496.1	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE	-

Sequence

Protein

Download Length: 952 a.a. Molecular weight: 105177.73 Da Isoelectric Point: 6.8954

                                >NTDB_id=847338 V4943_RS05495 WP_011173491.1 1044122..1046980(+) (uvrA) [Thermus thermophilus strain HB27_delta_csm3]

MDRIVIRGAREHNLKNISLELPRGKFIVITGVSGSGKSTLAFDTIYAEGQRRYVESLSSYARQFLGVMDKPEVESIEGLS

PAISIDQKTTSHNPRSTVGTVTEIHDYLRLLFARVGQAFCPECGRPIEKQSASEITDRLLRRPPGTRAILMAPLVRGRKG

EYRKLFQQLLKEGYARVRVDGVIYLLEEAQGLSLEKYEKHDIDLVIDRVVLKEEERPRIAEAVELALLRGEGLLRVLYPD

TGEEELFSEKFACPEHGSVLEELEPRIFSFNSPYGACPACSGLGYRQEFDPELVVNPELSLAEGAILPWSRGRDTGRSYL

WDRLRALAEHLGFDLKTPFKDLPEEAKRAVLYGLPEPFEVVFRRGGKETFRVEVRYEGVIPWLEKRYQESDSEGVREALE

GFMSLRPCPACGGTRYKREVLSVKVAGRNIAEVSALPVREALAFFQGLEKTLPPFQAQIARPILREIVERLGFLVDVGLD

YLTLDRAANTLSGGEAQRIRLATQVGSGLTGVLYVLDEPSIGLHPRDNQRLIRTLKRLRDLGNTLIVVEHDEETMRAADW

IVDMGPGAGIHGGEVVAQGTLEDILKSPQSLTGAYLRGEKRIPVPKERRKGNGKWLVLKGARAHNLKNVTLRIPLGRFVA

ITGPSGSGKSTLVHDVLYAALAQRLMRAKTTPGPYEALEGVEHLDKVIEIDQSPIGRTPRSNPATYTGVFDEIRDLFAKT

PEARKRGYGPGRFSFNVKGGRCEACGGDGTVKIEMLFLPDLYVPCEVCKGKRYNKETLEVKLRGKSIADVLDMTVEEALD

FFQNVPSIARKLQLMVDVGLGYMKLGQPSPTLSGGEAQRIKLATELGRKATGRTLYILDEPTTGLHFDDVAKLLSVLHRL

VDAGNTVVVIEHNLDVVKTADWVIDLGPEGGDRGGEIVAEGTPEEVALTGSPTGAFLARIPEIAARIGVAAD

Nucleotide

Download Length: 2859 bp

                                >NTDB_id=847338 V4943_RS05495 WP_011173491.1 1044122..1046980(+) (uvrA) [Thermus thermophilus strain HB27_delta_csm3]

ATGGACCGCATCGTCATCCGGGGCGCTCGGGAGCACAACCTGAAGAACATCAGCCTGGAGCTTCCCCGGGGCAAGTTCAT

CGTCATCACCGGGGTTTCCGGCTCGGGGAAAAGCACCTTGGCCTTTGACACCATCTACGCCGAGGGGCAGAGGCGCTACG

TGGAAAGCCTCTCCAGCTACGCCCGGCAGTTTCTGGGCGTGATGGACAAGCCCGAGGTGGAGAGCATTGAGGGGCTTTCC

CCGGCCATCTCCATTGACCAGAAGACCACGAGCCACAACCCCCGCTCCACCGTGGGCACCGTCACGGAGATCCACGACTA

CCTCCGCCTCCTCTTCGCCCGCGTGGGGCAGGCCTTCTGCCCCGAGTGCGGCCGTCCCATTGAGAAGCAGTCGGCGAGCG

AGATCACCGACCGCCTCCTCAGGCGCCCCCCCGGCACCCGGGCCATCCTCATGGCCCCCCTGGTGCGGGGAAGGAAGGGG

GAGTACAGGAAGCTCTTCCAGCAGCTCCTGAAGGAAGGCTACGCCCGGGTGCGGGTGGACGGGGTCATCTACCTCCTGGA

GGAGGCCCAAGGCCTCAGCCTGGAGAAGTACGAGAAGCACGACATTGACCTGGTGATTGACCGGGTGGTCCTGAAGGAGG

AGGAGCGCCCCCGCATCGCCGAGGCGGTGGAGCTCGCCCTGCTTCGGGGGGAAGGCCTTCTTCGGGTCCTCTACCCGGAC

ACCGGGGAAGAGGAGCTCTTCTCGGAGAAGTTCGCCTGCCCCGAGCACGGCTCGGTCCTGGAGGAGCTGGAGCCCCGCAT

CTTCTCCTTCAACAGCCCCTACGGGGCCTGCCCCGCCTGCTCCGGCCTCGGCTACCGCCAGGAGTTTGACCCCGAGCTCG

TGGTGAACCCCGAGCTCTCCCTGGCCGAGGGGGCCATCCTCCCCTGGTCCCGGGGGCGGGACACGGGGAGGAGCTACCTC

TGGGACCGCCTTAGGGCCTTGGCCGAGCACCTGGGCTTTGACCTCAAGACCCCCTTCAAGGACCTGCCGGAGGAGGCGAA

GCGCGCCGTCCTCTACGGCCTTCCCGAGCCCTTTGAGGTGGTCTTCCGCCGGGGCGGCAAGGAGACCTTCCGGGTGGAGG

TGCGGTACGAGGGGGTGATCCCCTGGCTGGAGAAGCGCTACCAGGAGTCCGACTCCGAGGGGGTGCGGGAGGCCCTGGAG

GGCTTCATGTCCTTAAGGCCCTGCCCCGCCTGCGGGGGCACCCGGTACAAGCGGGAGGTCCTCTCGGTGAAGGTGGCGGG

GAGGAACATCGCCGAGGTCTCCGCCCTCCCCGTGCGGGAGGCCTTGGCGTTCTTCCAGGGCCTGGAGAAGACCCTTCCCC

CCTTCCAGGCCCAGATCGCCCGGCCCATCCTCAGGGAGATCGTGGAGCGGCTCGGCTTCCTGGTGGACGTGGGCCTGGAC

TACCTCACCCTGGACCGGGCGGCCAACACCCTCTCCGGAGGCGAGGCCCAGAGGATCCGGCTCGCGACCCAGGTGGGCTC

GGGCCTCACCGGGGTCCTCTACGTGCTGGACGAGCCCAGCATCGGCCTCCACCCCCGGGACAACCAGCGCCTCATCCGCA

CCCTCAAAAGGCTCCGCGACCTGGGCAACACCCTCATCGTGGTGGAACACGACGAGGAGACCATGCGGGCCGCCGACTGG

ATCGTGGACATGGGTCCGGGGGCGGGGATCCACGGGGGGGAGGTGGTGGCCCAGGGCACCCTGGAGGACATCCTCAAAAG

CCCGCAAAGCCTCACCGGGGCCTACCTCAGGGGGGAGAAGAGGATCCCCGTGCCCAAGGAGCGCCGCAAGGGGAACGGCA

AGTGGCTCGTCCTCAAGGGGGCGCGGGCGCACAACCTGAAGAACGTCACCTTGAGGATCCCCCTGGGCCGCTTCGTGGCC

ATCACCGGCCCCTCGGGCTCGGGGAAGAGCACTCTCGTCCACGACGTCCTCTACGCCGCCCTGGCCCAAAGGCTCATGCG

GGCCAAGACGACCCCCGGCCCCTACGAGGCCCTGGAGGGGGTGGAGCACCTGGACAAGGTCATTGAGATTGACCAGTCCC

CCATCGGCCGCACCCCCCGGTCCAACCCCGCCACCTACACCGGGGTCTTTGACGAGATCCGCGACCTCTTCGCCAAGACC

CCGGAGGCCAGGAAGCGGGGGTACGGCCCAGGCCGCTTCTCCTTCAACGTCAAGGGCGGGCGGTGCGAGGCCTGCGGCGG

GGACGGGACGGTGAAGATTGAGATGCTCTTCCTCCCCGACCTCTACGTCCCCTGCGAGGTCTGCAAGGGCAAGCGCTACA

ACAAGGAGACCCTGGAGGTCAAGCTCAGGGGGAAGAGCATCGCCGACGTTCTGGACATGACGGTGGAGGAGGCCCTGGAC

TTCTTCCAGAACGTCCCCTCCATCGCCCGGAAGCTCCAGCTCATGGTGGACGTGGGCCTGGGGTACATGAAGCTGGGCCA

GCCCTCCCCCACCCTCTCCGGGGGGGAGGCCCAGAGGATCAAGCTCGCCACGGAGCTCGGCCGCAAGGCCACGGGCCGCA

CCCTCTACATCCTGGACGAGCCCACCACGGGCCTGCACTTTGACGACGTGGCGAAGCTCCTCTCGGTCCTCCACCGGTTG

GTGGACGCGGGCAACACCGTGGTGGTCATTGAGCACAACCTGGACGTGGTGAAGACCGCGGACTGGGTGATTGACCTGGG

CCCCGAGGGCGGGGACCGGGGCGGGGAGATCGTGGCCGAGGGCACCCCCGAGGAGGTGGCCCTCACGGGGAGCCCCACGG

GGGCCTTCCTCGCCCGGATCCCCGAGATCGCCGCCCGGATCGGGGTGGCGGCGGACTAA

Domains

Predicted by InterProScan.

UvrA interaction domain (UvrA_inter)

(130-239)

UvrA DNA-binding domain (UvrA_DNA-bind)

(290-400)

ABC transporter (ABC_tran)

(626-654)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	Q72IQ7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
uvrA	Streptococcus pneumoniae R6	56.688	98.95	0.561
uvrA	Streptococcus pneumoniae TIGR4	56.688	98.95	0.561
uvrA	Streptococcus pneumoniae D39	56.688	98.95	0.561

Detailed information NTG0847338