Detailed information NTG0084679

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: K5605_RS09770
• Genome accession: NZ_AP024313
• Coordinates: 1993134..1994177 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain N1195
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1988134..1999177

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
K5605_RS09740 (N1195TP_18420)	-	1988555..1989811 (-)	1257	WP_001793428.1	aminopeptidase	-
K5605_RS09745 (N1195TP_18430)	-	1989814..1990014 (-)	201	WP_000180460.1	DUF1128 family protein	-
K5605_RS09750 (N1195TP_18440)	-	1990161..1990625 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
K5605_RS09755 (N1195TP_18450)	-	1990632..1990907 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
K5605_RS09760 (N1195TP_18460)	-	1991185..1992402 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
K5605_RS09765 (N1195TP_18470)	vraR	1992515..1993144 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
K5605_RS09770 (N1195TP_18480)	vraS	1993134..1994177 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
K5605_RS09775 (N1195TP_18490)	liaF	1994174..1994875 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
K5605_RS09780 (N1195TP_18500)	-	1994890..1995276 (-)	387	WP_001110182.1	hypothetical protein	-
K5605_RS09785 (N1195TP_18510)	map	1995493..1996251 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
K5605_RS09790 (N1195TP_18530)	-	1996835..1997821 (+)	987	WP_000999712.1	aromatic acid exporter family protein	-
K5605_RS09795 (N1195TP_18540)	-	1998010..1998423 (-)	414	WP_025174370.1	hypothetical protein	-
K5605_RS09800	-	1998452..1998562 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=84679 K5605_RS09770 WP_001017131.1 1993134..1994177(-) (vraS) [Staphylococcus aureus strain N1195]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=84679 K5605_RS09770 WP_001017131.1 1993134..1994177(-) (vraS) [Staphylococcus aureus strain N1195]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1