Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   QQZ06_RS00340 Genome accession   NZ_CP127101
Coordinates   70776..72125 (-) Length   449 a.a.
NCBI ID   WP_064589291.1    Uniprot ID   -
Organism   Staphylococcus pseudintermedius strain 10916-77753     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 42578..77787 70776..72125 within 0


Gene organization within MGE regions


Location: 42578..77787
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  QQZ06_RS00205 (QQZ06_00205) ccrA 43904..45265 (-) 1362 WP_016170667.1 recombinase family protein Machinery gene
  QQZ06_RS00210 (QQZ06_00210) - 45565..47247 (-) 1683 Protein_39 DUF927 domain-containing protein -
  QQZ06_RS00215 (QQZ06_00215) - 47247..47543 (-) 297 WP_025176264.1 single-stranded DNA-binding protein -
  QQZ06_RS00220 (QQZ06_00220) - 47716..49230 (-) 1515 WP_016170664.1 hypothetical protein -
  QQZ06_RS00225 (QQZ06_00225) - 49376..50080 (+) 705 WP_016170663.1 FRG domain-containing protein -
  QQZ06_RS00230 (QQZ06_00230) tirS 50104..50946 (+) 843 WP_000114516.1 NAD(+) hydrolase TirS -
  QQZ06_RS00235 (QQZ06_00235) - 51235..51699 (+) 465 WP_025176263.1 hypothetical protein -
  QQZ06_RS00240 (QQZ06_00240) - 51809..51967 (+) 159 WP_225792520.1 alpha/beta hydrolase -
  QQZ06_RS00245 (QQZ06_00245) - 52285..52923 (+) 639 WP_025176262.1 FusC family fusidic acid resistance EF-G-binding protein -
  QQZ06_RS00250 (QQZ06_00250) - 53601..54374 (+) 774 WP_000998885.1 hypothetical protein -
  QQZ06_RS00255 (QQZ06_00255) - 54613..54972 (-) 360 WP_002434158.1 DUF4870 domain-containing protein -
  QQZ06_RS00260 (QQZ06_00260) - 55129..55254 (-) 126 WP_017175605.1 hypothetical protein -
  QQZ06_RS00265 (QQZ06_00265) - 55503..57365 (+) 1863 WP_032603224.1 DUF6038 family protein -
  QQZ06_RS00270 (QQZ06_00270) - 57570..57923 (+) 354 WP_032603225.1 hypothetical protein -
  QQZ06_RS00275 (QQZ06_00275) - 58012..59121 (+) 1110 WP_050482728.1 hypothetical protein -
  QQZ06_RS00280 (QQZ06_00280) - 59164..59745 (-) 582 Protein_53 IS6-like element IS257 family transposase -
  QQZ06_RS00285 (QQZ06_00285) - 59829..60170 (+) 342 WP_001797647.1 hydroxymethylglutaryl-CoA synthase -
  QQZ06_RS00290 (QQZ06_00290) - 61047..61790 (+) 744 WP_000958858.1 glycerophosphoryl diester phosphodiesterase -
  QQZ06_RS00295 (QQZ06_00295) - 61887..62315 (+) 429 WP_000872606.1 MaoC family dehydratase -
  QQZ06_RS00300 (QQZ06_00300) mecA 62361..64370 (-) 2010 WP_063852655.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  QQZ06_RS00305 (QQZ06_00305) - 64467..65453 (+) 987 WP_001549960.1 beta-lactam sensor/signal transducer MecR1 -
  QQZ06_RS00310 (QQZ06_00310) - 65425..65685 (+) 261 WP_001549961.1 type I restriction enzyme endonuclease domain-containing protein -
  QQZ06_RS00315 (QQZ06_00315) - 65676..67283 (-) 1608 Protein_60 IS1182 family transposase -
  QQZ06_RS00320 (QQZ06_00320) - 67335..67841 (-) 507 WP_001092189.1 DUF1643 domain-containing protein -
  QQZ06_RS00325 (QQZ06_00325) - 67856..68167 (-) 312 WP_000700851.1 DUF960 family protein -
  QQZ06_RS00330 (QQZ06_00330) - 68254..68604 (-) 351 WP_000849672.1 SAUGI family uracil-DNA glycosylase inhibitor -
  QQZ06_RS00335 (QQZ06_00335) ccrB 69126..70754 (-) 1629 WP_001186608.1 recombinase family protein Machinery gene
  QQZ06_RS00340 (QQZ06_00340) ccrA 70776..72125 (-) 1350 WP_064589291.1 recombinase family protein Machinery gene
  QQZ06_RS00345 (QQZ06_00345) - 72359..74146 (-) 1788 WP_000122620.1 DUF927 domain-containing protein -
  QQZ06_RS00350 (QQZ06_00350) - 74146..74436 (-) 291 WP_001036438.1 hypothetical protein -
  QQZ06_RS00355 (QQZ06_00355) - 74575..75624 (+) 1050 WP_000613248.1 hypothetical protein -
  QQZ06_RS00360 (QQZ06_00360) - 76297..77787 (+) 1491 WP_000554504.1 RNA-binding domain-containing protein -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52646.27 Da        Isoelectric Point: 9.9639

>NTDB_id=841806 QQZ06_RS00340 WP_064589291.1 70776..72125(-) (ccrA) [Staphylococcus pseudintermedius strain 10916-77753]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQITQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRLKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYDYH
HGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQTKQTPSDNQLKQKIKCPCCNATLTNMTIRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CRDFYQNQRIYTKIKSAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHIIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=841806 QQZ06_RS00340 WP_064589291.1 70776..72125(-) (ccrA) [Staphylococcus pseudintermedius strain 10916-77753]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGTCGCAAAGATAATCGTAGTGGGT
ATCGACAAATAACACAATTAATTCAACAAGGACAGTGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACGTACCATGTTCATATCTTAAGCGTACATGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGACTCAAGCTTAATATCTTCATCAGTTTAGCCGAACTTGAATCGGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACACATGCACCTTTTGGTTACGATTATCAC
CACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGCCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAACCAAACAGACACCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCATTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCACGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCCGAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAAGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATTGATGCAGAAACGTTCA
GAGAGCAAACACAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGGCATCAAATACAACACATCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATTGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase (Recombinase)

(169-250)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-321)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus N315

97.327

100

0.973
  ccrA Staphylococcus aureus COL

75.724

100

0.757