Detailed information
Bioinformatically predicted
Overview
| Name | ccrB | Type | Machinery gene |
| Locus tag | QQO10_RS00180 | Genome accession | NZ_CP127021 |
| Coordinates | 39646..41274 (-) | Length | 542 a.a. |
| NCBI ID | WP_001631035.1 | Uniprot ID | - |
| Organism | Staphylococcus aureus strain CC239-MRSA-III(var.) isolate Trinidad&Tobago_2020-021_7037M | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 39646..97049 | 39646..41274 | within | 0 |
Gene organization within MGE regions
Location: 39646..97049
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QQO10_RS00180 (QQO10_00180) | ccrB | 39646..41274 (-) | 1629 | WP_001631035.1 | cassette chromosome recombinase CcrB | Machinery gene |
| QQO10_RS00185 (QQO10_00185) | ccrA | 41271..42632 (-) | 1362 | WP_001631036.1 | cassette chromosome recombinase CcrA | Machinery gene |
| QQO10_RS00190 (QQO10_00190) | - | 42819..43448 (-) | 630 | Protein_35 | hypothetical protein | - |
| QQO10_RS00195 (QQO10_00195) | - | 43457..43795 (+) | 339 | Protein_36 | recombinase family protein | - |
| QQO10_RS00200 (QQO10_00200) | - | 43907..44266 (-) | 360 | WP_001631039.1 | hypothetical protein | - |
| QQO10_RS00205 (QQO10_00205) | - | 44473..44799 (+) | 327 | WP_000391495.1 | ArsR/SmtB family transcription factor | - |
| QQO10_RS00210 (QQO10_00210) | - | 45129..47054 (+) | 1926 | WP_285236894.1 | heavy metal translocating P-type ATPase | - |
| QQO10_RS00215 (QQO10_00215) | - | 48306..48611 (+) | 306 | WP_000677987.1 | hypothetical protein | - |
| QQO10_RS00220 (QQO10_00220) | - | 48809..49672 (+) | 864 | WP_000680579.1 | LEM-3-like GIY-YIG domain-containing protein | - |
| QQO10_RS00225 (QQO10_00225) | - | 49780..51254 (+) | 1475 | Protein_42 | DUF6038 family protein | - |
| QQO10_RS00230 (QQO10_00230) | - | 51481..52581 (+) | 1101 | WP_000449985.1 | DNA polymerase | - |
| QQO10_RS00235 (QQO10_00235) | - | 52574..52945 (+) | 372 | WP_001058157.1 | hypothetical protein | - |
| QQO10_RS00240 (QQO10_00240) | - | 52942..54585 (+) | 1644 | WP_001015579.1 | DUF5906 domain-containing protein | - |
| QQO10_RS00245 (QQO10_00245) | ccrC | 54810..56495 (+) | 1686 | WP_000676600.1 | cassette chromosome recombinase CcrC | - |
| QQO10_RS00250 (QQO10_00250) | tnpA | 56543..57028 (+) | 486 | WP_000093392.1 | IS200/IS605 family transposase | - |
| QQO10_RS00255 (QQO10_00255) | - | 57320..57658 (+) | 339 | WP_000175892.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| QQO10_RS00260 (QQO10_00260) | - | 57752..58063 (+) | 312 | WP_001166716.1 | DUF960 family protein | - |
| QQO10_RS00265 (QQO10_00265) | - | 58079..58585 (+) | 507 | WP_000848380.1 | DUF1643 domain-containing protein | - |
| QQO10_RS00270 (QQO10_00270) | - | 58606..58923 (+) | 318 | WP_000659046.1 | JAB domain-containing protein | - |
| QQO10_RS00275 (QQO10_00275) | - | 59042..60127 (+) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| QQO10_RS00280 (QQO10_00280) | - | 60124..62016 (+) | 1893 | WP_014532403.1 | site-specific integrase | - |
| QQO10_RS00285 (QQO10_00285) | - | 62023..62400 (+) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| QQO10_RS00290 (QQO10_00290) | - | 62551..63333 (+) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| QQO10_RS00295 (QQO10_00295) | erm(A) | 63459..64190 (-) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| QQO10_RS15775 | - | 64248..64307 (-) | 60 | WP_010959190.1 | erythromycin resistance leader peptide | - |
| QQO10_RS00300 (QQO10_00300) | - | 64699..65361 (+) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| QQO10_RS00305 (QQO10_00305) | - | 65593..65739 (+) | 147 | Protein_59 | JAB domain-containing protein | - |
| QQO10_RS00310 (QQO10_00310) | - | 65909..66781 (+) | 873 | WP_000373151.1 | HTH domain-containing protein | - |
| QQO10_RS00315 (QQO10_00315) | - | 66838..67128 (+) | 291 | WP_000065262.1 | hypothetical protein | - |
| QQO10_RS00320 (QQO10_00320) | - | 67144..67632 (+) | 489 | WP_000397419.1 | hypothetical protein | - |
| QQO10_RS00325 (QQO10_00325) | - | 67767..68294 (+) | 528 | WP_000717928.1 | hypothetical protein | - |
| QQO10_RS00330 (QQO10_00330) | - | 68356..68772 (+) | 417 | WP_000941331.1 | hypothetical protein | - |
| QQO10_RS00335 (QQO10_00335) | - | 69061..69225 (+) | 165 | WP_001803222.1 | hypothetical protein | - |
| QQO10_RS00340 (QQO10_00340) | - | 69239..69460 (+) | 222 | WP_001070883.1 | hypothetical protein | - |
| QQO10_RS00345 (QQO10_00345) | - | 69610..70176 (+) | 567 | WP_000759939.1 | PepSY domain-containing protein | - |
| QQO10_RS00350 (QQO10_00350) | - | 70256..72469 (-) | 2214 | Protein_68 | type I restriction endonuclease subunit R | - |
| QQO10_RS00355 (QQO10_00355) | - | 72531..73205 (-) | 675 | WP_001105999.1 | IS6-like element IS257 family transposase | - |
| QQO10_RS00360 (QQO10_00360) | - | 73241..73630 (+) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| QQO10_RS00365 (QQO10_00365) | - | 74627..75370 (+) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| QQO10_RS00370 (QQO10_00370) | - | 75467..75895 (+) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| QQO10_RS00375 (QQO10_00375) | mecA | 75941..77950 (-) | 2010 | WP_176427707.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| QQO10_RS00380 (QQO10_00380) | mecR1 | 78047..79804 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| QQO10_RS00385 (QQO10_00385) | mecI | 79804..80175 (+) | 372 | Protein_75 | mecA-type methicillin resistance repressor MecI | - |
| QQO10_RS00390 (QQO10_00390) | psm-mec | 80260..80328 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| QQO10_RS00395 (QQO10_00395) | - | 80648..81796 (+) | 1149 | WP_000427807.1 | ROK family transcriptional regulator | - |
| QQO10_RS00400 (QQO10_00400) | cstB | 81910..83244 (-) | 1335 | Protein_78 | persulfide dioxygenase-sulfurtransferase CstB | - |
| QQO10_RS00405 (QQO10_00405) | - | 83276..84340 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| QQO10_RS00410 (QQO10_00410) | cstR | 84476..84736 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| QQO10_RS00415 (QQO10_00415) | - | 84736..85373 (+) | 638 | Protein_81 | sulfite exporter TauE/SafE family protein | - |
| QQO10_RS00420 (QQO10_00420) | - | 85647..86264 (-) | 618 | WP_000562107.1 | CadD family cadmium resistance transporter | - |
| QQO10_RS00425 (QQO10_00425) | - | 86345..88759 (-) | 2415 | WP_000378486.1 | cadmium-translocating P-type ATPase CadA | - |
| QQO10_RS00430 (QQO10_00430) | - | 88752..89117 (-) | 366 | WP_000159127.1 | ArsR/SmtB family transcription factor | - |
| QQO10_RS00435 (QQO10_00435) | - | 89303..89681 (-) | 379 | Protein_85 | DUF6262 family protein | - |
| QQO10_RS00440 (QQO10_00440) | - | 89688..91580 (-) | 1893 | WP_014532403.1 | site-specific integrase | - |
| QQO10_RS00445 (QQO10_00445) | - | 91775..92098 (-) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| QQO10_RS00450 (QQO10_00450) | - | 92091..92297 (-) | 207 | WP_001077283.1 | hypothetical protein | - |
| QQO10_RS00455 (QQO10_00455) | - | 92299..92820 (-) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| QQO10_RS00460 (QQO10_00460) | - | 92839..93150 (-) | 312 | WP_000833212.1 | DUF960 family protein | - |
| QQO10_RS00465 (QQO10_00465) | - | 93235..93585 (-) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| QQO10_RS00470 (QQO10_00470) | ccrB | 94055..95682 (-) | 1628 | Protein_92 | cassette chromosome recombinase CcrB | - |
| QQO10_RS00475 (QQO10_00475) | ccrA | 95703..97049 (-) | 1347 | WP_000816499.1 | cassette chromosome recombinase CcrA | Machinery gene |
Sequence
Protein
Download Length: 542 a.a. Molecular weight: 62474.71 Da Isoelectric Point: 9.6103
>NTDB_id=841309 QQO10_RS00180 WP_001631035.1 39646..41274(-) (ccrB) [Staphylococcus aureus strain CC239-MRSA-III(var.) isolate Trinidad&Tobago_2020-021_7037M]
MKQLKKKRIGLYARVSTEMQTDGYSIQGQLNQLTEYCQFQGYEVVNEYTDRGISGKTMQRPELQRMLKDANEGKLDCIMV
YKTNRLARNTSDLLNIVEELYKINVEFFSLTEKIEIASSTGKLMLQILASFAEFERNTIVENVYNGQRQRAIEGYYQGNL
PLGYDKVPDSKKELMINQHEANIVKYIFDSYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYIISNPFYIGKIQFAKY
RHWSDKRRKGLNEEPIIADGKHAPIIDRNLWDKVQFKRQESRKKPQVHGKGTNLLTGIVKCPKCGAAMAASNTTNTLKDG
TKKRIRYYSCSNFRNKGSKVCSANSVRADVLEKYVMDQILEIIKSKKVLKQLVEKVNEKSQIDVSSLNHDIAYKQSQCEE
IKAKMHTLTKTIEDSPDLDSVLKPTILSYQDELNQINNQIYQLEQDKQAEAPHYDADMIANVLQAIFKDIDKLEKSQLKS
LYLTIIDRIDIRKDEHHKKQFYVTLKLNNDIIKQLFNNHPLDEVLPSTSSLFLPQTLYITIE
MKQLKKKRIGLYARVSTEMQTDGYSIQGQLNQLTEYCQFQGYEVVNEYTDRGISGKTMQRPELQRMLKDANEGKLDCIMV
YKTNRLARNTSDLLNIVEELYKINVEFFSLTEKIEIASSTGKLMLQILASFAEFERNTIVENVYNGQRQRAIEGYYQGNL
PLGYDKVPDSKKELMINQHEANIVKYIFDSYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYIISNPFYIGKIQFAKY
RHWSDKRRKGLNEEPIIADGKHAPIIDRNLWDKVQFKRQESRKKPQVHGKGTNLLTGIVKCPKCGAAMAASNTTNTLKDG
TKKRIRYYSCSNFRNKGSKVCSANSVRADVLEKYVMDQILEIIKSKKVLKQLVEKVNEKSQIDVSSLNHDIAYKQSQCEE
IKAKMHTLTKTIEDSPDLDSVLKPTILSYQDELNQINNQIYQLEQDKQAEAPHYDADMIANVLQAIFKDIDKLEKSQLKS
LYLTIIDRIDIRKDEHHKKQFYVTLKLNNDIIKQLFNNHPLDEVLPSTSSLFLPQTLYITIE
Nucleotide
Download Length: 1629 bp
>NTDB_id=841309 QQO10_RS00180 WP_001631035.1 39646..41274(-) (ccrB) [Staphylococcus aureus strain CC239-MRSA-III(var.) isolate Trinidad&Tobago_2020-021_7037M]
ATGAAACAACTCAAAAAGAAACGTATTGGATTATATGCACGTGTATCGACTGAAATGCAAACGGATGGTTACAGTATTCA
AGGTCAATTGAATCAACTTACAGAGTATTGTCAATTTCAAGGCTATGAAGTCGTCAATGAATACACCGATCGTGGTATAT
CAGGTAAAACAATGCAACGTCCAGAATTACAACGTATGTTAAAAGATGCCAACGAAGGTAAATTAGATTGTATTATGGTC
TACAAAACAAATCGTTTAGCTAGAAATACCTCAGATTTGTTAAATATTGTCGAGGAATTGTATAAGATTAATGTCGAATT
TTTTAGTCTAACTGAAAAAATAGAAATTGCCAGTTCAACAGGTAAATTGATGCTCCAAATTTTAGCCAGCTTCGCAGAAT
TTGAACGTAATACGATTGTAGAGAATGTCTACAATGGCCAAAGACAACGTGCTATTGAAGGTTATTATCAAGGTAATTTA
CCTCTAGGCTACGATAAAGTACCTGACAGTAAAAAAGAGCTCATGATCAATCAACATGAAGCGAATATTGTTAAATATAT
TTTTGATTCATACGCTAAAGGTCATGGTTATCGTAAGATTGCGAACGCATTGAATCATAAAGGTTATGTGACTAAGAAAG
GGAAACCTTTTAGTATTTCGTCCATTACCTACATCATCTCAAACCCTTTTTACATTGGAAAGATACAGTTTGCGAAGTAT
AGACACTGGAGCGATAAAAGACGAAAAGGACTCAATGAGGAACCGATTATCGCTGATGGTAAACATGCGCCTATTATTGA
TAGAAACCTATGGGATAAAGTACAGTTTAAACGTCAAGAGAGTCGCAAGAAACCACAAGTTCACGGCAAAGGAACAAACC
TACTGACTGGGATTGTAAAATGTCCGAAATGTGGTGCAGCAATGGCGGCAAGTAATACAACTAATACATTAAAAGATGGC
ACTAAGAAAAGAATCAGATATTACTCATGTAGCAATTTTAGAAATAAAGGTTCAAAAGTTTGTTCTGCCAATAGCGTTAG
AGCAGATGTACTAGAAAAATATGTTATGGATCAGATATTGGAAATTATCAAAAGCAAAAAGGTATTGAAGCAATTGGTTG
AAAAGGTAAATGAAAAAAGTCAAATAGACGTCTCTTCTTTGAACCATGATATTGCCTATAAACAGTCACAATGTGAAGAA
ATAAAAGCAAAAATGCATACATTAACGAAAACTATTGAAGACTCACCTGACTTAGATAGCGTATTAAAACCAACAATACT
TAGCTACCAAGATGAATTGAATCAAATAAATAATCAAATCTATCAACTAGAACAAGATAAACAAGCAGAAGCTCCACATT
ATGATGCTGATATGATTGCGAATGTACTACAAGCAATATTCAAAGATATAGACAAATTAGAGAAATCTCAGTTGAAATCA
CTATATCTAACAATCATCGATCGCATTGACATAAGAAAAGATGAGCATCATAAGAAGCAATTTTATGTTACGCTCAAGTT
AAATAATGATATAATCAAACAACTATTTAATAACCATCCACTCGACGAAGTGCTCCCTAGCACTTCGTCTTTATTTTTGC
CACAAACTTTATATATAACTATTGAATAA
ATGAAACAACTCAAAAAGAAACGTATTGGATTATATGCACGTGTATCGACTGAAATGCAAACGGATGGTTACAGTATTCA
AGGTCAATTGAATCAACTTACAGAGTATTGTCAATTTCAAGGCTATGAAGTCGTCAATGAATACACCGATCGTGGTATAT
CAGGTAAAACAATGCAACGTCCAGAATTACAACGTATGTTAAAAGATGCCAACGAAGGTAAATTAGATTGTATTATGGTC
TACAAAACAAATCGTTTAGCTAGAAATACCTCAGATTTGTTAAATATTGTCGAGGAATTGTATAAGATTAATGTCGAATT
TTTTAGTCTAACTGAAAAAATAGAAATTGCCAGTTCAACAGGTAAATTGATGCTCCAAATTTTAGCCAGCTTCGCAGAAT
TTGAACGTAATACGATTGTAGAGAATGTCTACAATGGCCAAAGACAACGTGCTATTGAAGGTTATTATCAAGGTAATTTA
CCTCTAGGCTACGATAAAGTACCTGACAGTAAAAAAGAGCTCATGATCAATCAACATGAAGCGAATATTGTTAAATATAT
TTTTGATTCATACGCTAAAGGTCATGGTTATCGTAAGATTGCGAACGCATTGAATCATAAAGGTTATGTGACTAAGAAAG
GGAAACCTTTTAGTATTTCGTCCATTACCTACATCATCTCAAACCCTTTTTACATTGGAAAGATACAGTTTGCGAAGTAT
AGACACTGGAGCGATAAAAGACGAAAAGGACTCAATGAGGAACCGATTATCGCTGATGGTAAACATGCGCCTATTATTGA
TAGAAACCTATGGGATAAAGTACAGTTTAAACGTCAAGAGAGTCGCAAGAAACCACAAGTTCACGGCAAAGGAACAAACC
TACTGACTGGGATTGTAAAATGTCCGAAATGTGGTGCAGCAATGGCGGCAAGTAATACAACTAATACATTAAAAGATGGC
ACTAAGAAAAGAATCAGATATTACTCATGTAGCAATTTTAGAAATAAAGGTTCAAAAGTTTGTTCTGCCAATAGCGTTAG
AGCAGATGTACTAGAAAAATATGTTATGGATCAGATATTGGAAATTATCAAAAGCAAAAAGGTATTGAAGCAATTGGTTG
AAAAGGTAAATGAAAAAAGTCAAATAGACGTCTCTTCTTTGAACCATGATATTGCCTATAAACAGTCACAATGTGAAGAA
ATAAAAGCAAAAATGCATACATTAACGAAAACTATTGAAGACTCACCTGACTTAGATAGCGTATTAAAACCAACAATACT
TAGCTACCAAGATGAATTGAATCAAATAAATAATCAAATCTATCAACTAGAACAAGATAAACAAGCAGAAGCTCCACATT
ATGATGCTGATATGATTGCGAATGTACTACAAGCAATATTCAAAGATATAGACAAATTAGAGAAATCTCAGTTGAAATCA
CTATATCTAACAATCATCGATCGCATTGACATAAGAAAAGATGAGCATCATAAGAAGCAATTTTATGTTACGCTCAAGTT
AAATAATGATATAATCAAACAACTATTTAATAACCATCCACTCGACGAAGTGCTCCCTAGCACTTCGTCTTTATTTTTGC
CACAAACTTTATATATAACTATTGAATAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrB | Staphylococcus aureus N315 |
72.694 |
100 |
0.727 |