Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | QQO11_RS00475 | Genome accession | NZ_CP127019 |
| Coordinates | 95704..97050 (-) | Length | 448 a.a. |
| NCBI ID | WP_000816499.1 | Uniprot ID | Q9R3W9 |
| Organism | Staphylococcus aureus strain CC239-MRSA-III(var.) isolate Trinidad&Tobago_2020-009_371M | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 39646..97050 | 95704..97050 | within | 0 |
Gene organization within MGE regions
Location: 39646..97050
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QQO11_RS00180 (QQO11_00180) | ccrB | 39646..41274 (-) | 1629 | WP_001631035.1 | cassette chromosome recombinase CcrB | Machinery gene |
| QQO11_RS00185 (QQO11_00185) | ccrA | 41271..42632 (-) | 1362 | WP_001631036.1 | cassette chromosome recombinase CcrA | Machinery gene |
| QQO11_RS00190 (QQO11_00190) | - | 42819..43448 (-) | 630 | Protein_35 | hypothetical protein | - |
| QQO11_RS00195 (QQO11_00195) | - | 43457..43795 (+) | 339 | Protein_36 | recombinase family protein | - |
| QQO11_RS00200 (QQO11_00200) | - | 43907..44266 (-) | 360 | WP_001631039.1 | hypothetical protein | - |
| QQO11_RS00205 (QQO11_00205) | - | 44473..44799 (+) | 327 | WP_000391495.1 | ArsR/SmtB family transcription factor | - |
| QQO11_RS00210 (QQO11_00210) | - | 45129..47054 (+) | 1926 | WP_002485723.1 | heavy metal translocating P-type ATPase | - |
| QQO11_RS00215 (QQO11_00215) | - | 48360..48611 (+) | 252 | WP_001823322.1 | hypothetical protein | - |
| QQO11_RS00220 (QQO11_00220) | - | 48809..49672 (+) | 864 | WP_000680579.1 | LEM-3-like GIY-YIG domain-containing protein | - |
| QQO11_RS00225 (QQO11_00225) | - | 49780..51254 (+) | 1475 | Protein_42 | DUF6038 family protein | - |
| QQO11_RS00230 (QQO11_00230) | - | 51481..52581 (+) | 1101 | WP_000449985.1 | DNA polymerase | - |
| QQO11_RS00235 (QQO11_00235) | - | 52574..52945 (+) | 372 | WP_001058157.1 | hypothetical protein | - |
| QQO11_RS00240 (QQO11_00240) | - | 52942..54585 (+) | 1644 | WP_001015579.1 | DUF5906 domain-containing protein | - |
| QQO11_RS00245 (QQO11_00245) | ccrC | 54810..56489 (+) | 1680 | WP_335343001.1 | cassette chromosome recombinase CcrC | - |
| QQO11_RS00250 (QQO11_00250) | tnpA | 56542..57027 (+) | 486 | WP_000093392.1 | IS200/IS605 family transposase | - |
| QQO11_RS00255 (QQO11_00255) | - | 57319..57657 (+) | 339 | WP_000175892.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| QQO11_RS00260 (QQO11_00260) | - | 57751..58062 (+) | 312 | WP_001166716.1 | DUF960 family protein | - |
| QQO11_RS00265 (QQO11_00265) | - | 58078..58584 (+) | 507 | WP_000848380.1 | DUF1643 domain-containing protein | - |
| QQO11_RS00270 (QQO11_00270) | - | 58605..58922 (+) | 318 | WP_000659046.1 | JAB domain-containing protein | - |
| QQO11_RS00275 (QQO11_00275) | - | 59041..60126 (+) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| QQO11_RS00280 (QQO11_00280) | - | 60123..62015 (+) | 1893 | WP_014532403.1 | site-specific integrase | - |
| QQO11_RS00285 (QQO11_00285) | - | 62022..62399 (+) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| QQO11_RS00290 (QQO11_00290) | - | 62585..62950 (+) | 366 | WP_000159127.1 | ArsR/SmtB family transcription factor | - |
| QQO11_RS00295 (QQO11_00295) | - | 62943..65357 (+) | 2415 | WP_000378486.1 | cadmium-translocating P-type ATPase CadA | - |
| QQO11_RS00300 (QQO11_00300) | - | 65438..66055 (+) | 618 | WP_000562107.1 | CadD family cadmium resistance transporter | - |
| QQO11_RS00305 (QQO11_00305) | - | 66329..66966 (-) | 638 | Protein_58 | sulfite exporter TauE/SafE family protein | - |
| QQO11_RS00310 (QQO11_00310) | cstR | 66966..67226 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| QQO11_RS00315 (QQO11_00315) | - | 67362..68426 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| QQO11_RS00320 (QQO11_00320) | cstB | 68458..69792 (+) | 1335 | Protein_61 | persulfide dioxygenase-sulfurtransferase CstB | - |
| QQO11_RS00325 (QQO11_00325) | - | 69906..71016 (-) | 1111 | Protein_62 | ROK family protein | - |
| QQO11_RS00330 (QQO11_00330) | psm-mec | 71375..71443 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| QQO11_RS00335 (QQO11_00335) | mecI | 71528..71899 (-) | 372 | Protein_64 | mecA-type methicillin resistance repressor MecI | - |
| QQO11_RS00340 (QQO11_00340) | mecR1 | 71899..73657 (-) | 1759 | Protein_65 | beta-lactam sensor/signal transducer MecR1 | - |
| QQO11_RS00345 (QQO11_00345) | mecA | 73757..75762 (+) | 2006 | Protein_66 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| QQO11_RS00350 (QQO11_00350) | - | 75808..76236 (-) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| QQO11_RS00355 (QQO11_00355) | - | 76333..77076 (-) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| QQO11_RS00360 (QQO11_00360) | - | 78073..78462 (-) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| QQO11_RS00365 (QQO11_00365) | - | 78498..79172 (+) | 675 | WP_001105999.1 | IS6-like element IS257 family transposase | - |
| QQO11_RS00370 (QQO11_00370) | - | 79234..81447 (+) | 2214 | Protein_71 | type I restriction endonuclease subunit R | - |
| QQO11_RS00375 (QQO11_00375) | - | 81527..82093 (-) | 567 | WP_000759939.1 | PepSY domain-containing protein | - |
| QQO11_RS00380 (QQO11_00380) | - | 82243..82464 (-) | 222 | WP_001070883.1 | hypothetical protein | - |
| QQO11_RS00385 (QQO11_00385) | - | 82478..82708 (-) | 231 | WP_285236817.1 | hypothetical protein | - |
| QQO11_RS00390 (QQO11_00390) | - | 82932..83348 (-) | 417 | WP_000941331.1 | hypothetical protein | - |
| QQO11_RS00395 (QQO11_00395) | - | 83410..83937 (-) | 528 | WP_000717928.1 | hypothetical protein | - |
| QQO11_RS00400 (QQO11_00400) | - | 84072..84560 (-) | 489 | WP_000397419.1 | hypothetical protein | - |
| QQO11_RS00405 (QQO11_00405) | - | 84576..84866 (-) | 291 | WP_000065262.1 | hypothetical protein | - |
| QQO11_RS00410 (QQO11_00410) | - | 84923..85795 (-) | 873 | WP_000373151.1 | HTH domain-containing protein | - |
| QQO11_RS00415 (QQO11_00415) | - | 85965..86111 (-) | 147 | Protein_80 | JAB domain-containing protein | - |
| QQO11_RS00420 (QQO11_00420) | - | 86343..87005 (-) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| QQO11_RS15915 | - | 87397..87456 (+) | 60 | WP_010959190.1 | erythromycin resistance leader peptide | - |
| QQO11_RS00425 (QQO11_00425) | erm(A) | 87514..88245 (+) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| QQO11_RS00430 (QQO11_00430) | - | 88371..89153 (-) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| QQO11_RS00435 (QQO11_00435) | - | 89304..89681 (-) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| QQO11_RS00440 (QQO11_00440) | - | 89688..91580 (-) | 1893 | WP_014532403.1 | site-specific integrase | - |
| QQO11_RS00445 (QQO11_00445) | - | 91775..92098 (-) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| QQO11_RS00450 (QQO11_00450) | - | 92091..92297 (-) | 207 | WP_001077283.1 | hypothetical protein | - |
| QQO11_RS00455 (QQO11_00455) | - | 92299..92820 (-) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| QQO11_RS00460 (QQO11_00460) | - | 92839..93150 (-) | 312 | WP_000833212.1 | DUF960 family protein | - |
| QQO11_RS00465 (QQO11_00465) | - | 93235..93585 (-) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| QQO11_RS00470 (QQO11_00470) | ccrB | 94056..95683 (-) | 1628 | Protein_92 | cassette chromosome recombinase CcrB | - |
| QQO11_RS00475 (QQO11_00475) | ccrA | 95704..97050 (-) | 1347 | WP_000816499.1 | cassette chromosome recombinase CcrA | Machinery gene |
Sequence
Protein
Download Length: 448 a.a. Molecular weight: 52138.19 Da Isoelectric Point: 10.1760
>NTDB_id=841267 QQO11_RS00475 WP_000816499.1 95704..97050(-) (ccrA) [Staphylococcus aureus strain CC239-MRSA-III(var.) isolate Trinidad&Tobago_2020-009_371M]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
Nucleotide
Download Length: 1347 bp
>NTDB_id=841267 QQO11_RS00475 WP_000816499.1 95704..97050(-) (ccrA) [Staphylococcus aureus strain CC239-MRSA-III(var.) isolate Trinidad&Tobago_2020-009_371M]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
78.174 |
100 |
0.783 |
| ccrA | Staphylococcus aureus N315 |
72.383 |
100 |
0.725 |