Detailed information NTG0840778

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: F6I26_RS02280
• Genome accession: NZ_CP126961
• Coordinates: 428745..429800 (+)
• Length: 351 a.a.
• NCBI ID: WP_024052081.1
• Uniprot ID: A0A413KQY5
• Organism: Streptococcus anginosus strain UMB4708
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 423745..434800

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
F6I26_RS02250 (F6I26_002250)	-	424266..424901 (-)	636	WP_024052085.1	YigZ family protein	-
F6I26_RS02255 (F6I26_002255)	comFA/cflA	424958..426259 (+)	1302	WP_024052084.1	DEAD/DEAH box helicase	Machinery gene
F6I26_RS02260 (F6I26_002260)	comFC/cflB	426256..426921 (+)	666	WP_024052083.1	ComF family protein	Machinery gene
F6I26_RS02265 (F6I26_002265)	raiA	426999..427541 (+)	543	WP_003025754.1	ribosome-associated translation inhibitor RaiA	-
F6I26_RS02270 (F6I26_002270)	rsmD	427729..428277 (+)	549	WP_171021853.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
F6I26_RS02275 (F6I26_002275)	coaD	428267..428764 (+)	498	WP_021001374.1	pantetheine-phosphate adenylyltransferase	-
F6I26_RS02280 (F6I26_002280)	sepM	428745..429800 (+)	1056	WP_024052081.1	SepM family pheromone-processing serine protease	Regulator
F6I26_RS02285 (F6I26_002285)	-	429939..430502 (+)	564	WP_024052080.1	YutD-like domain-containing protein	-
F6I26_RS02290 (F6I26_002290)	rlmN	430543..431625 (+)	1083	WP_024052079.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
F6I26_RS02295 (F6I26_002295)	-	431618..432148 (+)	531	WP_024052078.1	VanZ family protein	-
F6I26_RS02300 (F6I26_002300)	trpB	432509..433717 (+)	1209	Protein_412	tryptophan synthase subunit beta	-
F6I26_RS02305 (F6I26_002305)	cclA/cilC	433878..434537 (-)	660	WP_024052075.1	A24 family peptidase	Machinery gene

Sequence

Protein

• Length: 351 a.a.
• Molecular weight: 38290.25 Da
• Isoelectric Point: 10.1906

>NTDB_id=840778 F6I26_RS02280 WP_024052081.1 428745..429800(+) (sepM) [Streptococcus anginosus strain UMB4708]
MEKPRNKFKKWPIIAVVGVILLFLSFVVPLPYYIEVPGGAADVRQVLRVDNKEDKEKGSYNFVTVGIQHATLAHLVYAWL
TPFTDIYSAKDLTGGTSDKEYMRINQFYMETSQNLAKYQGLKKAGKDITLKYLGVYVLQVTKNSTFKGILNIADTVTGVN
DKTFNSSKELIDYVGAQKIGSKVKVNYVEDGQKKSATGKIIKLENGKNGIGISLIDRTEVTSNTPIEFSTAGIGGPSAGL
MFSLAIYTQIADPTLRDGRNIAGTGSIDREGKVGDIGGIDKKVVSAAKNGAEIFFAPNNPVTKEVKKSNPKAKTNYETAL
AAAKKIKTKMKIVPVKTLQDAIDYLKSTKKS

Nucleotide

• Length: 1056 bp

>NTDB_id=840778 F6I26_RS02280 WP_024052081.1 428745..429800(+) (sepM) [Streptococcus anginosus strain UMB4708]
ATGGAAAAACCAAGAAATAAATTTAAAAAATGGCCGATAATTGCAGTAGTAGGGGTGATTTTGCTTTTCTTATCTTTTGT
AGTTCCCTTGCCTTATTATATTGAGGTGCCAGGTGGTGCAGCGGATGTCCGTCAGGTATTGCGCGTGGACAACAAAGAAG
ATAAGGAAAAAGGTTCTTATAATTTTGTAACGGTTGGAATTCAGCATGCGACCCTCGCTCATTTGGTTTATGCTTGGCTG
ACACCTTTTACGGATATTTATTCGGCGAAGGATTTGACTGGTGGAACTTCTGATAAAGAATACATGCGGATCAATCAGTT
TTATATGGAAACGTCGCAAAACCTAGCTAAATACCAAGGGTTGAAAAAAGCTGGCAAAGACATTACTCTGAAATATCTAG
GGGTTTACGTCTTGCAAGTCACAAAGAATTCTACTTTTAAAGGTATTTTAAATATTGCAGATACCGTGACAGGTGTGAAT
GATAAGACTTTCAATAGTTCAAAAGAATTGATAGACTATGTCGGAGCGCAAAAGATTGGCAGCAAGGTCAAGGTGAACTA
TGTAGAAGACGGTCAGAAGAAGTCTGCTACAGGTAAAATTATTAAACTTGAAAATGGGAAAAACGGGATTGGCATTAGTT
TGATTGACCGAACAGAAGTCACAAGCAACACACCAATTGAATTTTCAACTGCCGGTATTGGTGGACCAAGTGCGGGCTTG
ATGTTTAGTTTGGCAATTTATACGCAAATTGCAGATCCAACATTGAGAGACGGCAGAAATATTGCTGGGACAGGTTCGAT
TGACCGAGAAGGAAAAGTTGGCGACATTGGTGGGATTGACAAAAAAGTTGTTTCAGCAGCTAAAAATGGCGCAGAAATTT
TCTTTGCGCCAAATAATCCAGTCACCAAGGAAGTGAAAAAATCCAATCCTAAAGCGAAAACAAACTATGAGACAGCTTTG
GCAGCTGCTAAAAAAATTAAAACTAAAATGAAAATTGTACCTGTCAAGACCTTGCAAGACGCAATTGATTACCTCAAGAG
CACAAAAAAGTCGTAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (234-307)

• PDZ domain (PDZ_2) (133-197)

3D structure

• AlphaFold DB: A0A413KQY5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	64.223	97.151	0.624