Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEA/celA/cilE   Type   Machinery gene
Locus tag   VKP40_RS03525 Genome accession   NZ_CP142355
Coordinates   679743..680405 (+) Length   220 a.a.
NCBI ID   WP_002995626.1    Uniprot ID   A0A0H2UV22
Organism   Streptococcus pyogenes strain A946     
Function   dsDNA binding to the cell surface (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 674743..685405
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VKP40_RS03505 (VKP40_03505) - 675617..677617 (+) 2001 WP_111686309.1 potassium transporter Kup -
  VKP40_RS03510 (VKP40_03510) - 677641..677919 (-) 279 WP_002989164.1 GIY-YIG nuclease family protein -
  VKP40_RS03515 (VKP40_03515) - 677909..678685 (-) 777 WP_080251042.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -
  VKP40_RS03520 (VKP40_03520) - 678803..679543 (+) 741 WP_012560804.1 lysophospholipid acyltransferase family protein -
  VKP40_RS03525 (VKP40_03525) comEA/celA/cilE 679743..680405 (+) 663 WP_002995626.1 ComEA family DNA-binding protein Machinery gene
  VKP40_RS03530 (VKP40_03530) - 680386..682628 (+) 2243 Protein_634 DNA internalization-related competence protein ComEC/Rec2 -
  VKP40_RS03535 (VKP40_03535) holA 682699..683739 (+) 1041 WP_011054659.1 DNA polymerase III subunit delta -
  VKP40_RS03540 (VKP40_03540) sodA 683836..684441 (+) 606 WP_002983977.1 superoxide dismutase SodA -
  VKP40_RS09085 - 684608..684841 (+) 234 WP_002983979.1 hypothetical protein -

Sequence

Protein


Download         Length: 220 a.a.        Molecular weight: 24623.45 Da        Isoelectric Point: 6.7451

>NTDB_id=840607 VKP40_RS03525 WP_002995626.1 679743..680405(+) (comEA/celA/cilE) [Streptococcus pyogenes strain A946]
MLDELLIKGKSFLRERYFLPYLISLLLGLFLILSFSFLFWGNRQSKAAVPALREISPVKQQVSEEKKEIQEDNSILVDLK
GAVQKEGVYKLTASSRVRDVIELAGGLTSEADKHAINFAEKLTDEQVVYVPKQGEEISVLPRSLVSGKKETASKDQSKVH
INKASLEELQHIPGIGAKRAQDIIDMRDKLGGFKALEDLRQVSGIGEKTLEKLKDDIFLD

Nucleotide


Download         Length: 663 bp        

>NTDB_id=840607 VKP40_RS03525 WP_002995626.1 679743..680405(+) (comEA/celA/cilE) [Streptococcus pyogenes strain A946]
ATGTTAGACGAATTATTAATTAAAGGAAAATCGTTTTTGAGAGAGCGGTATTTTCTGCCATACCTAATTAGTCTTTTATT
AGGACTTTTTCTAATACTAAGCTTCAGTTTTTTGTTCTGGGGAAATAGGCAGAGCAAGGCAGCCGTTCCTGCTTTGAGAG
AAATATCGCCTGTGAAACAGCAGGTTAGTGAAGAAAAAAAGGAAATTCAAGAAGATAACAGTATTTTAGTGGATTTAAAA
GGCGCCGTACAAAAAGAGGGAGTTTATAAGCTAACTGCTAGCAGTCGTGTGCGAGATGTCATTGAACTAGCTGGAGGCCT
AACTTCAGAAGCTGATAAACATGCTATTAATTTTGCAGAAAAACTAACTGATGAGCAAGTTGTTTATGTACCTAAACAAG
GAGAAGAGATTTCTGTGCTACCAAGGTCATTAGTTTCTGGTAAAAAAGAAACTGCCAGCAAGGATCAGTCAAAGGTTCAT
ATTAATAAGGCCAGCTTAGAAGAACTACAACATATCCCAGGTATTGGTGCTAAAAGAGCTCAGGATATTATTGATATGAG
AGATAAGTTAGGTGGTTTTAAAGCGTTAGAAGATCTCCGTCAGGTTTCGGGGATTGGCGAAAAAACGCTCGAGAAATTAA
AAGATGACATTTTCTTGGACTAA

Domains

Predicted by InterProScan.

SLBB domain (SLBB)

(77-130)

Helix-hairpin-helix motif (HHH_3)

(156-217)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0H2UV22

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEA/celA/cilE Streptococcus pneumoniae TIGR4

42.995

94.091

0.405