Detailed information NTG0084048

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SA231_RS13685
• Genome accession: NZ_AP024203
• Coordinates: 2738898..2739941 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain SA23-1
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2733898..2744941

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SA231_RS13655 (SA231_26060)	-	2734319..2735566 (-)	1248	WP_000656302.1	aminopeptidase	-
SA231_RS13660 (SA231_26070)	-	2735578..2735778 (-)	201	WP_000180459.1	DUF1128 family protein	-
SA231_RS13665 (SA231_26080)	-	2735925..2736389 (+)	465	WP_000228668.1	low molecular weight protein-tyrosine-phosphatase	-
SA231_RS13670 (SA231_26090)	-	2736396..2736671 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
SA231_RS13675 (SA231_26100)	-	2736949..2738166 (+)	1218	WP_000037083.1	YihY/virulence factor BrkB family protein	-
SA231_RS13680 (SA231_26110)	vraR	2738279..2738908 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
SA231_RS13685 (SA231_26120)	vraS	2738898..2739941 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
SA231_RS13690 (SA231_26130)	liaF	2739938..2740639 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
SA231_RS13695 (SA231_26140)	-	2740654..2741040 (-)	387	WP_001110184.1	hypothetical protein	-
SA231_RS13700 (SA231_26150)	map	2741257..2742015 (-)	759	WP_000636137.1	type I methionyl aminopeptidase	-
SA231_RS13705 (SA231_26160)	-	2742658..2743644 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
SA231_RS13710 (SA231_26170)	-	2743822..2744235 (-)	414	WP_001622129.1	hypothetical protein	-
SA231_RS13715	-	2744264..2744373 (-)	110	Protein_2664	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=84048 SA231_RS13685 WP_001017131.1 2738898..2739941(-) (vraS) [Staphylococcus aureus strain SA23-1]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=84048 SA231_RS13685 WP_001017131.1 2738898..2739941(-) (vraS) [Staphylococcus aureus strain SA23-1]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTACCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTCGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1