Detailed information NTG0838756

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: LLUL007_RS11480
• Genome accession: NZ_CP126569
• Coordinates: 2204823..2205854 (-)
• Length: 343 a.a.
• NCBI ID: WP_011677213.1
• Uniprot ID: A0A166ZHD8
• Organism: Lactococcus cremoris strain UL007
• Function: processing of CSP (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IScluster/Tn	2200976..2203938	2204823..2205854	flank	885

Gene organization within MGE regions

Location: 2200976..2205854

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LLUL007_RS11445 (LLUL007_11505)	-	2200976..2201866 (-)	891	Protein_2224	IS982 family transposase	-
LLUL007_RS11450 (LLUL007_11510)	-	2202166..2202663 (-)	498	WP_011677211.1	nitroreductase family protein	-
LLUL007_RS11455 (LLUL007_11515)	-	2202650..2202859 (-)	210	WP_011677212.1	hypothetical protein	-
LLUL007_RS11460 (LLUL007_11520)	-	2202856..2203080 (-)	225	WP_014573364.1	hypothetical protein	-
LLUL007_RS11465 (LLUL007_11525)	-	2203147..2204036 (+)	890	Protein_2228	IS982-like element IS982B family transposase	-
LLUL007_RS11470 (LLUL007_11530)	-	2204018..2204323 (-)	306	WP_396425816.1	hypothetical protein	-
LLUL007_RS11475 (LLUL007_11535)	-	2204391..2204504 (-)	114	WP_011836076.1	KxxxW-cyclized peptide pheromone	-
LLUL007_RS11480 (LLUL007_11540)	sepM	2204823..2205854 (-)	1032	WP_011677213.1	SepM family pheromone-processing serine protease	Regulator

Sequence

Protein

• Length: 343 a.a.
• Molecular weight: 37398.03 Da
• Isoelectric Point: 9.8499

>NTDB_id=838756 LLUL007_RS11480 WP_011677213.1 2204823..2205854(-) (sepM) [Lactococcus cremoris strain UL007]
MKKKNKKISPKLKWGISIGLIIVALLVLVYPTNYYVEMPGTTEPLGKMVKVEGKKDEHKGDFFLTTVQIARANLATMIYS
HFNSFTSIYSEQEMTGGLNDAQFNRVNQFYMETAQNTAVYQAFKLANKPYELKYEGVYVLDIAKNSTFKNKLELSDTITA
VNGEEFKSSADMIAYVSKQKVGDSVTIEYTRIDGSKHKSTGKYIKIANGKTGIGIGLVDHTEVVTDPKVTVNAGSIGGPS
AGIMFTLEIYSQLTGKDLRGGREIAGTGTIEHDGSIGQIGGVDKKVATASKEGAKVFLVPDSGTKKESSNNYLGAKAAAK
KLKTKMKIVPVKTIQDALDYLEK

Nucleotide

• Length: 1032 bp

>NTDB_id=838756 LLUL007_RS11480 WP_011677213.1 2204823..2205854(-) (sepM) [Lactococcus cremoris strain UL007]
ATGAAGAAAAAAAATAAAAAAATCAGTCCCAAATTAAAATGGGGCATCTCTATTGGTCTGATTATTGTCGCTCTCCTTGT
TTTAGTGTATCCAACAAATTACTATGTGGAAATGCCTGGAACAACCGAGCCATTAGGAAAAATGGTCAAAGTCGAAGGAA
AAAAAGATGAGCACAAAGGTGACTTTTTCCTTACTACCGTTCAAATTGCGCGCGCTAATCTTGCCACAATGATTTACAGT
CATTTTAATAGTTTTACAAGCATTTACAGTGAACAAGAAATGACCGGTGGCCTTAATGATGCGCAGTTCAATCGTGTCAA
CCAGTTTTACATGGAAACGGCACAAAATACAGCCGTTTATCAGGCCTTCAAGTTGGCAAATAAACCCTATGAACTGAAAT
ATGAAGGGGTTTATGTCCTTGATATCGCTAAAAATTCGACTTTTAAAAATAAATTGGAACTTTCGGACACGATTACAGCA
GTCAATGGGGAAGAATTTAAATCAAGTGCAGATATGATTGCTTACGTTTCGAAGCAAAAAGTCGGCGATTCAGTTACCAT
TGAATATACACGGATTGATGGAAGTAAACACAAGTCTACTGGAAAATATATCAAAATCGCTAATGGAAAAACTGGAATCG
GAATTGGACTAGTTGACCATACTGAAGTAGTCACAGACCCAAAAGTTACAGTCAATGCAGGTTCAATCGGTGGACCATCT
GCCGGAATAATGTTTACACTAGAGATTTACAGTCAGTTGACAGGTAAAGATTTACGTGGTGGTCGCGAAATAGCAGGAAC
TGGAACGATTGAACATGATGGAAGCATTGGCCAAATCGGTGGGGTTGATAAAAAAGTAGCTACTGCTAGCAAAGAAGGCG
CAAAAGTTTTCTTAGTTCCTGACTCAGGCACCAAAAAAGAAAGCAGCAATAACTATCTTGGAGCCAAAGCAGCCGCTAAA
AAATTAAAAACGAAGATGAAAATTGTTCCCGTCAAGACTATTCAGGACGCTTTAGATTATTTAGAAAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (229-339)

• PDZ domain (PDZ_2) (135-193)

3D structure

• AlphaFold DB: A0A166ZHD8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	48.696	100	0.49