Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | QMK35_RS00410 | Genome accession | NZ_CP126540 |
| Coordinates | 86269..87618 (-) | Length | 449 a.a. |
| NCBI ID | WP_040030082.1 | Uniprot ID | - |
| Organism | Staphylococcus cohnii strain SDAQ-1 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 39155..105398 | 86269..87618 | within | 0 |
Gene organization within MGE regions
Location: 39155..105398
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QMK35_RS00170 (QMK35_00170) | mecA | 39155..41164 (-) | 2010 | WP_063852655.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| QMK35_RS00175 (QMK35_00175) | mecR1 | 41261..43018 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| QMK35_RS00180 (QMK35_00180) | mecI | 43018..43389 (+) | 372 | WP_025904161.1 | mecA-type methicillin resistance repressor MecI | - |
| QMK35_RS00185 (QMK35_00185) | psm-mec | 43474..43542 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| QMK35_RS00190 (QMK35_00190) | - | 43862..45010 (+) | 1149 | WP_075773656.1 | ROK family transcriptional regulator | - |
| QMK35_RS00195 (QMK35_00195) | cstB | 45124..46458 (-) | 1335 | Protein_36 | persulfide dioxygenase-sulfurtransferase CstB | - |
| QMK35_RS00200 (QMK35_00200) | - | 46491..47555 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| QMK35_RS00205 (QMK35_00205) | cstR | 47691..47951 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| QMK35_RS00210 (QMK35_00210) | - | 47951..48589 (+) | 639 | Protein_39 | sulfite exporter TauE/SafE family protein | - |
| QMK35_RS00215 (QMK35_00215) | - | 48863..49480 (-) | 618 | WP_000562107.1 | CadD family cadmium resistance transporter | - |
| QMK35_RS00220 (QMK35_00220) | - | 49561..51975 (-) | 2415 | WP_198054454.1 | heavy metal translocating P-type ATPase | - |
| QMK35_RS00225 (QMK35_00225) | - | 51968..52333 (-) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| QMK35_RS00230 (QMK35_00230) | - | 52571..52948 (-) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| QMK35_RS00235 (QMK35_00235) | - | 52955..54847 (-) | 1893 | WP_002485298.1 | site-specific integrase | - |
| QMK35_RS00240 (QMK35_00240) | - | 55042..55365 (-) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| QMK35_RS00245 (QMK35_00245) | - | 55358..55564 (-) | 207 | WP_001077283.1 | hypothetical protein | - |
| QMK35_RS00250 (QMK35_00250) | - | 55566..56087 (-) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| QMK35_RS00255 (QMK35_00255) | - | 56106..56417 (-) | 312 | WP_000833212.1 | DUF960 family protein | - |
| QMK35_RS00260 (QMK35_00260) | - | 56502..56852 (-) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| QMK35_RS00265 (QMK35_00265) | - | 57419..58153 (-) | 735 | WP_044291471.1 | glucose 1-dehydrogenase | - |
| QMK35_RS00270 (QMK35_00270) | ccrB | 58241..59869 (-) | 1629 | WP_198054455.1 | cassette chromosome recombinase CcrB | Machinery gene |
| QMK35_RS00275 (QMK35_00275) | ccrA | 59891..61240 (-) | 1350 | WP_210124230.1 | cassette chromosome recombinase CcrA | Machinery gene |
| QMK35_RS00280 (QMK35_00280) | - | 61429..61707 (-) | 279 | WP_070373498.1 | hypothetical protein | - |
| QMK35_RS00285 (QMK35_00285) | cch1 | 61797..63584 (-) | 1788 | WP_070373489.1 | cassette chromosome replicative helicase | - |
| QMK35_RS00290 (QMK35_00290) | ssb | 63586..63822 (-) | 237 | WP_070373490.1 | cassette chromosome ssDNA-binding protein | - |
| QMK35_RS00295 (QMK35_00295) | - | 64025..65563 (-) | 1539 | WP_204186964.1 | hypothetical protein | - |
| QMK35_RS00300 (QMK35_00300) | - | 65673..66836 (+) | 1164 | WP_285159723.1 | helix-turn-helix domain-containing protein | - |
| QMK35_RS00305 (QMK35_00305) | - | 66849..66977 (+) | 129 | WP_269322899.1 | hypothetical protein | - |
| QMK35_RS00310 (QMK35_00310) | - | 67090..67653 (+) | 564 | WP_285159724.1 | abortive infection family protein | - |
| QMK35_RS13580 | - | 67854..67997 (-) | 144 | WP_369077090.1 | DUF1958 domain-containing protein | - |
| QMK35_RS00315 (QMK35_00315) | - | 68071..68826 (-) | 756 | WP_070373492.1 | sulfite exporter TauE/SafE family protein | - |
| QMK35_RS00320 (QMK35_00320) | cstR | 68826..69086 (-) | 261 | WP_070373493.1 | persulfide-sensing transcriptional repressor CstR | - |
| QMK35_RS00325 (QMK35_00325) | cstA | 69224..70291 (+) | 1068 | WP_075100270.1 | persulfide response sulfurtransferase CstA | - |
| QMK35_RS00330 (QMK35_00330) | cstB | 70320..71654 (+) | 1335 | WP_285159725.1 | persulfide dioxygenase-sulfurtransferase CstB | - |
| QMK35_RS00335 (QMK35_00335) | chrA | 71847..73010 (-) | 1164 | WP_070373496.1 | chromate efflux transporter | - |
| QMK35_RS00340 (QMK35_00340) | - | 73021..73323 (-) | 303 | WP_025905228.1 | PadR family transcriptional regulator | - |
| QMK35_RS00345 (QMK35_00345) | arsC | 73449..73850 (-) | 402 | WP_075100272.1 | arsenate reductase (thioredoxin) | - |
| QMK35_RS00350 (QMK35_00350) | arsB | 73868..75160 (-) | 1293 | WP_285159960.1 | arsenite efflux transporter membrane subunit ArsB | - |
| QMK35_RS00355 (QMK35_00355) | - | 75157..75474 (-) | 318 | WP_011274435.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| QMK35_RS00360 (QMK35_00360) | - | 75743..77803 (+) | 2061 | WP_025905371.1 | heavy metal translocating P-type ATPase | - |
| QMK35_RS00365 (QMK35_00365) | - | 77821..78366 (+) | 546 | WP_037537668.1 | YdhK family protein | - |
| QMK35_RS00370 (QMK35_00370) | - | 78677..80092 (+) | 1416 | WP_103322421.1 | hypothetical protein | - |
| QMK35_RS00375 (QMK35_00375) | - | 80115..80837 (-) | 723 | WP_103322422.1 | site-specific DNA-methyltransferase | - |
| QMK35_RS00380 (QMK35_00380) | - | 80854..81729 (-) | 876 | WP_239102456.1 | Dam family site-specific DNA-(adenine-N6)-methyltransferase | - |
| QMK35_RS00385 (QMK35_00385) | - | 81746..82771 (-) | 1026 | WP_239102458.1 | DNA adenine methylase | - |
| QMK35_RS00390 (QMK35_00390) | - | 82874..83386 (-) | 513 | WP_103323364.1 | DUF1643 domain-containing protein | - |
| QMK35_RS00395 (QMK35_00395) | - | 83402..83713 (-) | 312 | WP_103323363.1 | DUF960 family protein | - |
| QMK35_RS00400 (QMK35_00400) | - | 83809..84147 (-) | 339 | WP_103323362.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| QMK35_RS00405 (QMK35_00405) | ccrB | 84622..86247 (-) | 1626 | WP_285159726.1 | cassette chromosome recombinase CcrB | Machinery gene |
| QMK35_RS00410 (QMK35_00410) | ccrA | 86269..87618 (-) | 1350 | WP_040030082.1 | cassette chromosome recombinase CcrA | Machinery gene |
| QMK35_RS00415 (QMK35_00415) | - | 87796..88053 (-) | 258 | WP_002434121.1 | hypothetical protein | - |
| QMK35_RS00420 (QMK35_00420) | cch1 | 88118..89908 (-) | 1791 | WP_210127845.1 | cassette chromosome replicative helicase | - |
| QMK35_RS00425 (QMK35_00425) | - | 89908..90177 (-) | 270 | WP_031838353.1 | hypothetical protein | - |
| QMK35_RS00430 (QMK35_00430) | - | 90332..91891 (-) | 1560 | WP_194376024.1 | hypothetical protein | - |
| QMK35_RS00435 (QMK35_00435) | - | 91993..92835 (+) | 843 | WP_194440955.1 | toll/interleukin-1 receptor domain-containing protein | - |
| QMK35_RS00440 (QMK35_00440) | - | 92933..93298 (+) | 366 | Protein_86 | helix-turn-helix transcriptional regulator | - |
| QMK35_RS00445 (QMK35_00445) | - | 93256..94023 (-) | 768 | WP_107517540.1 | alpha/beta fold hydrolase | - |
| QMK35_RS00450 (QMK35_00450) | - | 94155..94424 (+) | 270 | WP_228481256.1 | hypothetical protein | - |
| QMK35_RS00455 (QMK35_00455) | - | 94555..95559 (-) | 1005 | WP_021339370.1 | NADP-dependent oxidoreductase | - |
| QMK35_RS00460 (QMK35_00460) | - | 95749..96090 (+) | 342 | WP_002506307.1 | MerR family transcriptional regulator | - |
| QMK35_RS00465 (QMK35_00465) | - | 96163..96522 (+) | 360 | WP_021339372.1 | DUF1304 domain-containing protein | - |
| QMK35_RS00470 (QMK35_00470) | - | 96597..96749 (-) | 153 | WP_285159727.1 | hypothetical protein | - |
| QMK35_RS00475 (QMK35_00475) | - | 97033..97164 (+) | 132 | WP_264291862.1 | hypothetical protein | - |
| QMK35_RS00480 (QMK35_00480) | - | 97222..97395 (+) | 174 | WP_157948031.1 | hypothetical protein | - |
| QMK35_RS00485 (QMK35_00485) | - | 97571..97831 (+) | 261 | WP_107520697.1 | hypothetical protein | - |
| QMK35_RS00490 (QMK35_00490) | - | 97865..98677 (+) | 813 | WP_107393048.1 | helix-turn-helix domain-containing protein | - |
| QMK35_RS00495 (QMK35_00495) | - | 98691..100166 (+) | 1476 | WP_107393055.1 | DUF6038 family protein | - |
| QMK35_RS00500 (QMK35_00500) | - | 100393..101493 (+) | 1101 | WP_107393049.1 | hypothetical protein | - |
| QMK35_RS00505 (QMK35_00505) | - | 101486..101854 (+) | 369 | WP_037576907.1 | hypothetical protein | - |
| QMK35_RS00510 (QMK35_00510) | - | 101854..103497 (+) | 1644 | WP_070038559.1 | DUF5906 domain-containing protein | - |
| QMK35_RS00515 (QMK35_00515) | ccrC | 103722..105398 (+) | 1677 | WP_192945136.1 | cassette chromosome recombinase CcrC | - |
Sequence
Protein
Download Length: 449 a.a. Molecular weight: 52328.94 Da Isoelectric Point: 9.9834
>NTDB_id=838663 QMK35_RS00410 WP_040030082.1 86269..87618(-) (ccrA) [Staphylococcus cohnii strain SDAQ-1]
MKQAMGYLRQSTTKQQSLAAQKQTIKVLAEKHNIQHITFYSDKQSGRTDKRNGYQQITELIQQGQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFISLAELESDNIGEQVKNGIKEKAKQGKLITTHAPFGYHYH
NGTFTIDTVKSPTVKAVFNYYLQGYGYKKIAQYLEADDKFINRKPYQVRNIILNPNYCGRVINQYGQYENMFPAIVSTTI
YEEAQVTRTQKQVKRKPSENQLKQKIKCPYCHSTLTNMTVRKTDHSLRYYVCPQNMNNARFVCEFKGINAQELETSVLAI
CQDFFQNQQLYSKINHTIQQRLKRQRDVETKTTLNHEQLIEKLAQGKIDAETFREQTRSLHQQSKPLSSISAYQIRNAFQ
NIIQQRFTLNMLNPYIDVISITKNKTLAGIYFKNEPLNIVNQTTQSSIA
MKQAMGYLRQSTTKQQSLAAQKQTIKVLAEKHNIQHITFYSDKQSGRTDKRNGYQQITELIQQGQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFISLAELESDNIGEQVKNGIKEKAKQGKLITTHAPFGYHYH
NGTFTIDTVKSPTVKAVFNYYLQGYGYKKIAQYLEADDKFINRKPYQVRNIILNPNYCGRVINQYGQYENMFPAIVSTTI
YEEAQVTRTQKQVKRKPSENQLKQKIKCPYCHSTLTNMTVRKTDHSLRYYVCPQNMNNARFVCEFKGINAQELETSVLAI
CQDFFQNQQLYSKINHTIQQRLKRQRDVETKTTLNHEQLIEKLAQGKIDAETFREQTRSLHQQSKPLSSISAYQIRNAFQ
NIIQQRFTLNMLNPYIDVISITKNKTLAGIYFKNEPLNIVNQTTQSSIA
Nucleotide
Download Length: 1350 bp
>NTDB_id=838663 QMK35_RS00410 WP_040030082.1 86269..87618(-) (ccrA) [Staphylococcus cohnii strain SDAQ-1]
ATGAAACAAGCAATGGGTTACTTACGACAGAGCACTACAAAGCAACAATCTCTAGCAGCACAAAAACAAACCATCAAGGT
ATTAGCCGAAAAACATAATATTCAACACATTACCTTTTATAGCGATAAACAATCAGGACGTACTGATAAGCGGAATGGTT
ATCAACAAATTACTGAACTGATTCAACAGGGACAATGTGACGTATTATGTTGCTATCGTCTAAATCGACTTCATCGTAAT
TTGAAAAATGCATTAAAACTCATGAAATTGTGTCAAAAATACCATGTCCATATCTTAAGCGTTCATGATGGCTACTTCGA
CATGGATAAAGCATTCGATCGGCTCAAACTCAATATTTTCATCAGCTTGGCCGAACTAGAATCTGATAATATAGGCGAAC
AAGTCAAAAATGGAATCAAAGAAAAAGCGAAACAAGGTAAACTGATTACAACACATGCACCCTTTGGGTATCACTATCAT
AATGGTACTTTCACGATAGACACAGTAAAATCACCAACAGTAAAAGCTGTGTTCAATTATTACCTTCAAGGTTATGGTTA
TAAAAAAATTGCGCAATACTTAGAAGCTGATGATAAATTCATTAATCGCAAGCCCTATCAAGTGCGTAATATTATCCTTA
ACCCTAATTACTGTGGCCGTGTTATCAATCAATACGGACAATATGAAAACATGTTCCCAGCTATTGTCAGTACAACGATA
TACGAAGAAGCTCAAGTTACCCGAACTCAGAAACAAGTCAAACGTAAGCCGTCAGAAAACCAACTCAAACAAAAAATCAA
ATGTCCCTATTGTCATTCGACACTCACAAACATGACTGTCCGAAAAACAGATCATTCATTGCGTTACTATGTCTGTCCGC
AAAATATGAATAATGCTCGCTTTGTTTGTGAATTTAAAGGAATCAACGCACAAGAATTAGAAACAAGTGTTTTAGCGATT
TGTCAGGACTTCTTTCAAAATCAACAGCTCTATTCAAAAATAAACCATACTATTCAACAACGACTCAAAAGACAAAGAGA
TGTAGAAACTAAAACTACACTCAATCACGAGCAGCTGATAGAAAAATTAGCCCAAGGCAAAATTGATGCAGAAACGTTCA
GAGAACAAACGCGTTCATTACATCAACAATCAAAACCTTTATCATCAATCAGTGCGTATCAAATTCGAAATGCTTTCCAA
AACATCATTCAACAACGTTTCACACTAAACATGCTGAATCCCTATATTGATGTAATTAGTATTACTAAAAACAAAACCCT
TGCGGGGATCTATTTCAAAAATGAACCTCTAAACATTGTCAATCAAACGACGCAATCATCGATTGCTTAA
ATGAAACAAGCAATGGGTTACTTACGACAGAGCACTACAAAGCAACAATCTCTAGCAGCACAAAAACAAACCATCAAGGT
ATTAGCCGAAAAACATAATATTCAACACATTACCTTTTATAGCGATAAACAATCAGGACGTACTGATAAGCGGAATGGTT
ATCAACAAATTACTGAACTGATTCAACAGGGACAATGTGACGTATTATGTTGCTATCGTCTAAATCGACTTCATCGTAAT
TTGAAAAATGCATTAAAACTCATGAAATTGTGTCAAAAATACCATGTCCATATCTTAAGCGTTCATGATGGCTACTTCGA
CATGGATAAAGCATTCGATCGGCTCAAACTCAATATTTTCATCAGCTTGGCCGAACTAGAATCTGATAATATAGGCGAAC
AAGTCAAAAATGGAATCAAAGAAAAAGCGAAACAAGGTAAACTGATTACAACACATGCACCCTTTGGGTATCACTATCAT
AATGGTACTTTCACGATAGACACAGTAAAATCACCAACAGTAAAAGCTGTGTTCAATTATTACCTTCAAGGTTATGGTTA
TAAAAAAATTGCGCAATACTTAGAAGCTGATGATAAATTCATTAATCGCAAGCCCTATCAAGTGCGTAATATTATCCTTA
ACCCTAATTACTGTGGCCGTGTTATCAATCAATACGGACAATATGAAAACATGTTCCCAGCTATTGTCAGTACAACGATA
TACGAAGAAGCTCAAGTTACCCGAACTCAGAAACAAGTCAAACGTAAGCCGTCAGAAAACCAACTCAAACAAAAAATCAA
ATGTCCCTATTGTCATTCGACACTCACAAACATGACTGTCCGAAAAACAGATCATTCATTGCGTTACTATGTCTGTCCGC
AAAATATGAATAATGCTCGCTTTGTTTGTGAATTTAAAGGAATCAACGCACAAGAATTAGAAACAAGTGTTTTAGCGATT
TGTCAGGACTTCTTTCAAAATCAACAGCTCTATTCAAAAATAAACCATACTATTCAACAACGACTCAAAAGACAAAGAGA
TGTAGAAACTAAAACTACACTCAATCACGAGCAGCTGATAGAAAAATTAGCCCAAGGCAAAATTGATGCAGAAACGTTCA
GAGAACAAACGCGTTCATTACATCAACAATCAAAACCTTTATCATCAATCAGTGCGTATCAAATTCGAAATGCTTTCCAA
AACATCATTCAACAACGTTTCACACTAAACATGCTGAATCCCTATATTGATGTAATTAGTATTACTAAAAACAAAACCCT
TGCGGGGATCTATTTCAAAAATGAACCTCTAAACATTGTCAATCAAACGACGCAATCATCGATTGCTTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
92.65 |
100 |
0.927 |
| ccrA | Staphylococcus aureus N315 |
74.833 |
100 |
0.748 |