Detailed information NTG0083087

Bioinformatically predicted

Overview

• Name: htrA
• Type: Regulator
• Locus tag: H7680_RS10335
• Genome accession: NZ_AP023394
• Coordinates: 2106159..2107382 (+)
• Length: 407 a.a.
• NCBI ID: WP_003054444.1
• Uniprot ID: A0A9X8T5D3
• Organism: Streptococcus dysgalactiae subsp. equisimilis strain 159
• Function: require for competence development (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IS/Tn	2104241..2105224	2106159..2107382	flank	935

Gene organization within MGE regions

Location: 2104241..2107382

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H7680_RS10320 (SDSE159_20260)	-	2104241..2105224 (+)	984	WP_184006749.1	IS30 family transposase	-
H7680_RS10330 (SDSE159_20270)	rlmH	2105468..2105947 (-)	480	WP_003057960.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
H7680_RS10335 (SDSE159_20280)	htrA	2106159..2107382 (+)	1224	WP_003054444.1	trypsin-like peptidase domain-containing protein	Regulator

Sequence

Protein

• Length: 407 a.a.
• Molecular weight: 42746.35 Da
• Isoelectric Point: 7.3920

>NTDB_id=83087 H7680_RS10335 WP_003054444.1 2106159..2107382(+) (htrA) [Streptococcus dysgalactiae subsp. equisimilis strain 159]
MPSMKHILKSLSVLLIGFLGGLIAIITFNNLYPHSPSKINSGKATTSNMVFNNTTNTTKAVKAVQNAVVSVINYQDNPSS
SLSNPYTKLFGEGRSKENKDAELSIFSEGSGVIYRKDGNSAYVVTNNHVIDGAKRIEILMADGSKVVGELVGADTYSDLA
VVKISSDKIKTVAEFADSTKLNVGEVAIAIGSPLGTQYANSVTQGIVSSLSRTVTLKNENGETVSTNAIQTDAAINPGNS
GGPLINIEGQVIGINSSKISSTPTGSNGNSGAVEGIGFAIPSTDVIKIIKQLETNGEVIRPALGISMVNLNDLSTNALSQ
INIPTSVTGGIVVAEVKEGMPASGKLAQYDVITEIDGKTVNSISDLQSSLYGHDINDTIKVTFYRGTTKKKADIKLTKTT
QDLTKTQ

Nucleotide

• Length: 1224 bp

>NTDB_id=83087 H7680_RS10335 WP_003054444.1 2106159..2107382(+) (htrA) [Streptococcus dysgalactiae subsp. equisimilis strain 159]
ATGCCAAGTATGAAACATATCTTAAAATCCTTAAGTGTTTTACTAATTGGATTTTTAGGAGGATTAATAGCAATTATTAC
ATTTAATAATCTCTACCCACATTCTCCTTCAAAAATAAATTCAGGTAAGGCAACAACTAGTAATATGGTTTTTAACAACA
CAACCAATACTACTAAAGCTGTCAAAGCTGTTCAAAATGCAGTGGTATCAGTTATTAATTATCAAGATAACCCTTCTTCA
TCCCTTTCTAACCCTTATACAAAACTCTTTGGAGAAGGGCGTTCAAAAGAGAATAAGGATGCTGAATTATCTATTTTTAG
TGAAGGATCTGGGGTCATTTATCGAAAAGATGGCAACTCCGCTTACGTTGTTACTAATAACCATGTTATCGACGGAGCTA
AACGGATTGAAATTCTTATGGCAGACGGATCTAAAGTTGTTGGTGAATTAGTTGGAGCTGATACTTATTCGGATTTAGCT
GTTGTTAAGATCTCTTCAGATAAGATAAAAACAGTAGCTGAATTTGCAGACTCTACAAAACTAAATGTTGGAGAAGTTGC
TATTGCTATCGGCAGCCCACTAGGAACACAATACGCTAATTCTGTTACTCAAGGAATCGTCTCTAGTTTAAGTCGTACTG
TAACTTTAAAAAACGAGAATGGTGAGACTGTCTCAACAAATGCTATTCAGACAGATGCTGCTATTAATCCTGGAAACTCT
GGTGGACCACTAATTAATATTGAGGGGCAAGTAATCGGAATTAATTCAAGTAAAATTTCTTCTACCCCAACTGGTAGCAA
CGGTAATAGTGGTGCTGTTGAAGGAATTGGTTTTGCTATCCCATCTACTGATGTTATTAAAATTATTAAACAGCTAGAAA
CTAATGGTGAAGTTATCAGACCTGCTCTTGGAATATCCATGGTCAATTTAAATGATTTATCCACAAATGCTCTTAGCCAA
ATTAATATTCCAACTAGTGTAACTGGTGGTATTGTAGTAGCAGAAGTTAAGGAAGGAATGCCGGCATCTGGCAAACTTGC
TCAGTACGATGTGATTACAGAAATTGATGGCAAAACAGTTAATTCAATTAGTGATTTACAAAGTAGTCTATACGGACACG
ATATTAATGATACTATTAAAGTAACTTTTTATAGAGGAACTACAAAGAAAAAAGCAGATATCAAATTAACAAAAACTACT
CAAGATTTGACTAAAACGCAGTAA

Domains

Predicted by InterproScan.

• Trypsin-like peptidase domain (Trypsin_2) (109-254)

• PDZ domain (PDZ_2) (301-396)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
htrA	Streptococcus mutans UA159	61.634	99.263	0.612
htrA	Streptococcus gordonii str. Challis substr. CH1	55.473	98.771	0.548
htrA	Streptococcus mitis NCTC 12261	53.317	100	0.533
htrA	Streptococcus pneumoniae Rx1	53.071	100	0.531
htrA	Streptococcus pneumoniae D39	53.071	100	0.531
htrA	Streptococcus pneumoniae R6	53.071	100	0.531
htrA	Streptococcus pneumoniae TIGR4	53.071	100	0.531