Detailed information NTG0082953

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: H7679_RS04380
• Genome accession: NZ_AP023392
• Coordinates: 861062..861733 (+)
• Length: 223 a.a.
• NCBI ID: WP_014637852.1
• Uniprot ID: G7SGW2
• Organism: Streptococcus suis strain DAT300
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 856062..866733

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H7679_RS04350 (DAT300_08130)	pstC	856278..857195 (+)	918	WP_002937619.1	phosphate ABC transporter permease subunit PstC	-
H7679_RS04355 (DAT300_08140)	pstA	857185..858072 (+)	888	WP_014635996.1	phosphate ABC transporter permease PstA	-
H7679_RS04360 (DAT300_08150)	pstB	858097..858900 (+)	804	WP_002940866.1	phosphate ABC transporter ATP-binding protein PstB	-
H7679_RS04365 (DAT300_08160)	pstB	858912..859670 (+)	759	WP_024395285.1	phosphate ABC transporter ATP-binding protein PstB	-
H7679_RS04370 (DAT300_08170)	phoU	859699..860355 (+)	657	WP_002937611.1	phosphate signaling complex protein PhoU	-
H7679_RS04375 (DAT300_08180)	-	860521..860868 (+)	348	WP_014635995.1	hypothetical protein	-
H7679_RS04380 (DAT300_08190)	ciaR	861062..861733 (+)	672	WP_014637852.1	response regulator transcription factor	Regulator
H7679_RS04385 (DAT300_08200)	ciaH	861726..863105 (+)	1380	WP_014635993.1	sensor histidine kinase	Regulator
H7679_RS04390 (DAT300_08210)	-	863205..864434 (+)	1230	WP_024395287.1	transglutaminase domain-containing protein	-
H7679_RS04395 (DAT300_08220)	tnpA	864811..865275 (+)	465	WP_002939996.1	IS200/IS605-like element ISSsu4 family transposase	-
H7679_RS04400 (DAT300_08230)	rpsT	865417..865665 (-)	249	WP_012027069.1	30S ribosomal protein S20	-
H7679_RS04405 (DAT300_08240)	coaA	865724..866644 (-)	921	WP_002940857.1	type I pantothenate kinase	-

Sequence

Protein

• Length: 223 a.a.
• Molecular weight: 25245.83 Da
• Isoelectric Point: 4.2183

>NTDB_id=82953 H7679_RS04380 WP_014637852.1 861062..861733(+) (ciaR) [Streptococcus suis strain DAT300]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGEEGIYEAETGVYDLILLDLMLPEKDGFQVLKELREKGVTTPVLITTA
KESLEDKGHGFELGADDYLTKPFYLEELKMRIQALLKRAGKFNENTLTYGDVTVDLSTNSTTVNGEEVELLGKEFDLLVY
FLQNQNVILPKTQIFDRIWGFDSDTTISVVEVYVSKIRKKLKGTTFGENLQTLRSVGYILKNA

Nucleotide

• Length: 672 bp

>NTDB_id=82953 H7679_RS04380 WP_014637852.1 861062..861733(+) (ciaR) [Streptococcus suis strain DAT300]
ATGATTAAAATATTGTTAGTGGAAGATGATTTAAGTCTATCAAATTCTGTTTTCGATTTCTTGGATGATTTTGCGGATGT
TATGCAGGTTTTTGATGGTGAAGAGGGTATTTATGAGGCGGAAACAGGCGTTTATGATTTGATTCTTTTGGATTTGATGT
TGCCTGAAAAAGATGGCTTCCAAGTTTTGAAAGAGTTACGTGAAAAAGGTGTTACGACACCAGTTCTGATTACAACAGCC
AAGGAAAGTCTAGAGGATAAAGGCCATGGTTTTGAATTGGGAGCTGATGACTACTTGACAAAACCGTTTTATTTAGAAGA
ATTGAAGATGCGAATTCAAGCTCTATTAAAACGAGCGGGTAAGTTTAATGAAAACACACTAACTTATGGGGATGTGACCG
TTGACTTATCGACAAACTCTACAACTGTAAATGGCGAAGAAGTTGAATTGCTAGGAAAAGAATTCGATCTACTAGTCTAC
TTTTTGCAAAATCAAAATGTTATCTTGCCAAAAACTCAAATTTTTGACCGTATTTGGGGATTTGACAGTGACACTACTAT
TTCAGTAGTAGAAGTATATGTTTCTAAAATTAGGAAAAAGTTGAAAGGAACGACTTTCGGGGAAAATCTTCAAACCCTGC
GTAGTGTCGGGTACATTCTAAAAAATGCCTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (145-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: G7SGW2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	90.135	100	0.901
ciaR	Streptococcus pneumoniae Rx1	88.789	100	0.888
ciaR	Streptococcus pneumoniae D39	88.789	100	0.888
ciaR	Streptococcus pneumoniae R6	88.789	100	0.888
ciaR	Streptococcus pneumoniae TIGR4	88.789	100	0.888
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.053	100	0.386
vicR	Streptococcus mutans UA159	35.47	100	0.372
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.368