Detailed information NTG0082850

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: H7676_RS05735
• Genome accession: NZ_AP023390
• Coordinates: 1168198..1169235 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain KUN-0014944
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1163198..1174235

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H7676_RS05715	-	1163942..1164568 (+)	627	WP_002983834.1	prepilin peptidase	-
H7676_RS05720 (KUN4944_10940)	rlmN	1164649..1165727 (-)	1079	Protein_1100	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
H7676_RS05725 (KUN4944_10950)	-	1165731..1166351 (-)	621	WP_002992791.1	YutD family protein	-
H7676_RS05730 (KUN4944_10960)	-	1166799..1167776 (-)	978	WP_031577505.1	LacI family DNA-binding transcriptional regulator	-
H7676_RS05735 (KUN4944_10970)	sepM	1168198..1169235 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
H7676_RS05740 (KUN4944_10980)	coaD	1169222..1169713 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
H7676_RS05745 (KUN4944_10990)	rsmD	1169703..1170242 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
H7676_RS05750 (KUN4944_11000)	asnA	1170365..1171357 (-)	993	WP_002983817.1	aspartate--ammonia ligase	-
H7676_RS05755 (KUN4944_11010)	arcC	1171670..1172620 (-)	951	WP_010922501.1	carbamate kinase	-
H7676_RS05760 (KUN4944_11020)	-	1172640..1173971 (-)	1332	WP_030126384.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=82850 H7676_RS05735 WP_010922499.1 1168198..1169235(-) (sepM) [Streptococcus pyogenes strain KUN-0014944]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=82850 H7676_RS05735 WP_010922499.1 1168198..1169235(-) (sepM) [Streptococcus pyogenes strain KUN-0014944]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTATTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTCTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693