Detailed information NTG0082786

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: H7675_RS03340
• Genome accession: NZ_AP023389
• Coordinates: 644647..645684 (+)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain KUN-0012590
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 639647..650684

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
H7675_RS03315 (KUN2590_05930)	-	639911..641242 (+)	1332	WP_030126384.1	dipeptidase	-
H7675_RS03320 (KUN2590_05940)	arcC	641262..642212 (+)	951	WP_010922501.1	carbamate kinase	-
H7675_RS03325 (KUN2590_05950)	asnA	642525..643517 (+)	993	WP_002983817.1	aspartate--ammonia ligase	-
H7675_RS03330 (KUN2590_05960)	rsmD	643640..644179 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
H7675_RS03335 (KUN2590_05970)	coaD	644169..644660 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
H7675_RS03340 (KUN2590_05980)	sepM	644647..645684 (+)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
H7675_RS03345 (KUN2590_05990)	-	646106..647083 (+)	978	WP_031577505.1	LacI family DNA-binding transcriptional regulator	-
H7675_RS03350 (KUN2590_06000)	-	647531..648151 (+)	621	WP_002992791.1	YutD family protein	-
H7675_RS03355 (KUN2590_06010)	rlmN	648155..649234 (+)	1080	WP_031488529.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
H7675_RS03360	-	649316..649942 (-)	627	WP_002983834.1	prepilin peptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=82786 H7675_RS03340 WP_010922499.1 644647..645684(+) (sepM) [Streptococcus pyogenes strain KUN-0012590]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=82786 H7675_RS03340 WP_010922499.1 644647..645684(+) (sepM) [Streptococcus pyogenes strain KUN-0012590]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTATTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTCTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693