Detailed information    

insolico Bioinformatically predicted

Overview

Name   sepM   Type   Regulator
Locus tag   H7674_RS03125 Genome accession   NZ_AP023388
Coordinates   623027..624064 (+) Length   345 a.a.
NCBI ID   WP_011284961.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain NIH35     
Function   processing of CSP (predicted from homology)   
Competence regulation

Genomic Context

Location: 618027..629064
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  H7674_RS03100 (SPNIH35_05530) - 618291..619622 (+) 1332 WP_011284962.1 dipeptidase -
  H7674_RS03105 (SPNIH35_05540) arcC 619642..620592 (+) 951 WP_009880962.1 carbamate kinase -
  H7674_RS03110 (SPNIH35_05550) asnA 620905..621897 (+) 993 WP_002983817.1 aspartate--ammonia ligase -
  H7674_RS03115 (SPNIH35_05560) rsmD 622020..622559 (+) 540 WP_002983819.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
  H7674_RS03120 (SPNIH35_05570) coaD 622549..623040 (+) 492 WP_002983821.1 pantetheine-phosphate adenylyltransferase -
  H7674_RS03125 (SPNIH35_05580) sepM 623027..624064 (+) 1038 WP_011284961.1 SepM family pheromone-processing serine protease Regulator
  H7674_RS03130 (SPNIH35_05590) - 624479..625456 (+) 978 WP_021341005.1 LacI family DNA-binding transcriptional regulator -
  H7674_RS03135 (SPNIH35_05600) - 625904..626524 (+) 621 WP_002992791.1 YutD family protein -
  H7674_RS03140 (SPNIH35_05610) rlmN 626528..627607 (+) 1080 WP_002992788.1 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN -
  H7674_RS03145 - 627689..628315 (-) 627 WP_002983834.1 prepilin peptidase -

Sequence

Protein


Download         Length: 345 a.a.        Molecular weight: 37571.27 Da        Isoelectric Point: 9.6692

>NTDB_id=82733 H7674_RS03125 WP_011284961.1 623027..624064(+) (sepM) [Streptococcus pyogenes strain NIH35]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDTDFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide


Download         Length: 1038 bp        

>NTDB_id=82733 H7674_RS03125 WP_011284961.1 623027..624064(+) (sepM) [Streptococcus pyogenes strain NIH35]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATACTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

Lon protease (S16) C-terminal proteolytic domain (Lon_C)

(233-309)

PDZ domain (PDZ_2)

(129-192)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  sepM Streptococcus mutans UA159

68.986

100

0.69

Multiple sequence alignment