Detailed information NTG0082683

Bioinformatically predicted

Overview

• Name: dprA
• Type: Machinery gene
• Locus tag: KUN2590_RS05410
• Genome accession: NZ_AP023387
• Coordinates: 1008145..1008981 (+)
• Length: 278 a.a.
• NCBI ID: WP_011054501.1
• Uniprot ID: A0A5S4TKN4
• Organism: Streptococcus pyogenes strain NIH34
• Function: ssDNA binding; loading RecA onto ssDNA (predicted from homology) DNA processing

Genomic Context

Location: 1003145..1013981

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KUN2590_RS05380 (SPNIH34_10230)	-	1003693..1004067 (+)	375	WP_011054498.1	hypothetical protein	-
KUN2590_RS05385 (SPNIH34_10240)	-	1004117..1005028 (-)	912	WP_002984631.1	diacylglycerol/lipid kinase family protein	-
KUN2590_RS05390 (SPNIH34_10250)	trhA	1005145..1005795 (-)	651	WP_002984629.1	PAQR family membrane homeostasis protein TrhA	-
KUN2590_RS05395 (SPNIH34_10260)	-	1005792..1006232 (-)	441	WP_002989774.1	DUF1836 domain-containing protein	-
KUN2590_RS05400 (SPNIH34_10270)	ylqF	1006451..1007299 (+)	849	WP_011054499.1	ribosome biogenesis GTPase YlqF	-
KUN2590_RS05405 (SPNIH34_10280)	-	1007289..1008080 (+)	792	WP_011054500.1	ribonuclease HII	-
KUN2590_RS05410 (SPNIH34_10290)	dprA	1008145..1008981 (+)	837	WP_011054501.1	DNA-processing protein DprA	Machinery gene
KUN2590_RS05415 (SPNIH34_10300)	topA	1009087..1011216 (+)	2130	WP_011054502.1	type I DNA topoisomerase	-
KUN2590_RS05420 (SPNIH34_10310)	trmFO	1011351..1012697 (+)	1347	WP_032461335.1	methylenetetrahydrofolate--tRNA-(uracil(54)- C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO	-

Sequence

Protein

• Length: 278 a.a.
• Molecular weight: 31087.14 Da
• Isoelectric Point: 9.4248

>NTDB_id=82683 KUN2590_RS05410 WP_011054501.1 1008145..1008981(+) (dprA) [Streptococcus pyogenes strain NIH34]
MNHFELYKLKKAGLTNKNILNILDYQKHQEKSLSLRDMAVVSGCKHPSHFIEAYKQLDIQKLKMEFKQFPSISILDKHYP
MALKEIYNPPVLLFFQGNLDLLEKPKLAIVGSRRSSDTGVKSVRKILKELGNRFVIVSGLARGIDTSAHLACLKNGGQTI
AIIGTGLDRFYPKENRELQTFLGKNHLVLTEYGPREEALSYHFPERNRIIAGLSRGILVVEAKNRSGSLITCQIGIEEGR
DIFAVPGNILDGKSEGCLQLIKEGATCVTSGMDILSEY

Nucleotide

• Length: 837 bp

>NTDB_id=82683 KUN2590_RS05410 WP_011054501.1 1008145..1008981(+) (dprA) [Streptococcus pyogenes strain NIH34]
GTGAATCATTTTGAACTTTATAAGCTAAAGAAAGCTGGACTGACTAATAAAAACATTCTCAATATTCTTGACTACCAAAA
ACACCAGGAAAAATCGTTGTCACTTCGAGATATGGCCGTTGTTTCTGGTTGTAAGCATCCGTCTCACTTTATAGAAGCCT
ATAAGCAGTTAGATATTCAAAAATTAAAAATGGAATTTAAACAATTTCCTAGTATTTCTATCTTAGATAAGCATTACCCA
ATGGCATTGAAAGAAATATACAATCCACCTGTCCTCTTGTTTTTTCAGGGAAATTTAGACCTTCTTGAGAAACCTAAATT
AGCCATTGTCGGCTCCAGACGCTCAAGCGATACCGGAGTAAAGTCTGTCCGTAAAATTCTTAAAGAACTCGGGAACCGTT
TTGTGATTGTTAGCGGACTTGCTCGAGGTATCGACACTAGTGCTCATTTAGCCTGCCTTAAAAATGGGGGACAAACCATC
GCTATTATTGGAACAGGGTTGGATCGCTTTTACCCTAAAGAAAATAGGGAGTTGCAAACTTTCTTAGGGAAAAATCATCT
TGTGCTAACAGAATACGGTCCAAGAGAAGAAGCTTTATCTTATCACTTTCCAGAACGGAATCGTATTATCGCAGGCCTTA
GCCGAGGTATTCTTGTCGTTGAAGCAAAAAATCGTTCAGGTTCCTTGATTACTTGTCAAATTGGGATAGAAGAAGGCCGA
GACATTTTTGCTGTCCCAGGAAACATTTTGGACGGGAAATCCGAAGGTTGCCTTCAGTTAATTAAAGAGGGAGCAACATG
CGTCACATCGGGCATGGATATCCTTTCAGAGTACTAA

Domains

Predicted by InterproScan.

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (1-62)

• DNA recombination-mediator protein A (DNA_processg_A) (68-269)

3D structure

• AlphaFold DB: A0A5S4TKN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA	Streptococcus mutans UA159	67.266	100	0.673
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	60.072	100	0.601
dprA/cilB/dalA	Streptococcus pneumoniae D39	60.072	100	0.601
dprA/cilB/dalA	Streptococcus pneumoniae R6	60.072	100	0.601
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	60.072	100	0.601
dprA/cilB/dalA	Streptococcus mitis SK321	60.072	100	0.601
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	59.712	100	0.597
dprA	Lactococcus lactis subsp. cremoris KW2	57.194	100	0.572
dprA	Legionella pneumophila strain ERS1305867	42.857	85.612	0.367