Detailed information NTG0082677

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: KUN2590_RS03715
• Genome accession: NZ_AP023387
• Coordinates: 687887..688924 (+)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain NIH34
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 682887..693924

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
KUN2590_RS03690 (SPNIH34_06730)	-	683151..684482 (+)	1332	WP_011054719.1	dipeptidase	-
KUN2590_RS03695 (SPNIH34_06740)	arcC	684502..685452 (+)	951	WP_003051912.1	carbamate kinase	-
KUN2590_RS03700 (SPNIH34_06750)	asnA	685765..686757 (+)	993	WP_002983817.1	aspartate--ammonia ligase	-
KUN2590_RS03705 (SPNIH34_06760)	rsmD	686880..687419 (+)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
KUN2590_RS03710 (SPNIH34_06770)	coaD	687409..687900 (+)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
KUN2590_RS03715 (SPNIH34_06780)	sepM	687887..688924 (+)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
KUN2590_RS03720 (SPNIH34_06790)	-	689338..690315 (+)	978	WP_011054718.1	LacI family DNA-binding transcriptional regulator	-
KUN2590_RS03725 (SPNIH34_06800)	-	690763..691383 (+)	621	WP_002992791.1	YutD family protein	-
KUN2590_RS03730 (SPNIH34_06810)	rlmN	691387..692466 (+)	1080	WP_002992788.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
KUN2590_RS03735	-	692548..693174 (-)	627	WP_002989076.1	prepilin peptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=82677 KUN2590_RS03715 WP_010922499.1 687887..688924(+) (sepM) [Streptococcus pyogenes strain NIH34]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=82677 KUN2590_RS03715 WP_010922499.1 687887..688924(+) (sepM) [Streptococcus pyogenes strain NIH34]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693