Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   KUN2590_RS01295 Genome accession   NZ_AP023387
Coordinates   238018..238779 (+) Length   253 a.a.
NCBI ID   WP_011106593.1    Uniprot ID   A0A5S4TK55
Organism   Streptococcus pyogenes strain NIH34     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 233018..243779
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  KUN2590_RS01280 (SPNIH34_02060) - 233276..234844 (-) 1569 WP_011054179.1 ABC transporter substrate-binding protein/permease -
  KUN2590_RS01285 (SPNIH34_02070) - 235042..236967 (+) 1926 WP_011054180.1 DUF2207 domain-containing protein -
  KUN2590_RS01290 (SPNIH34_02080) - 237033..237872 (+) 840 WP_002986031.1 undecaprenyl-diphosphate phosphatase -
  KUN2590_RS01295 (SPNIH34_02090) mecA 238018..238779 (+) 762 WP_011106593.1 adaptor protein MecA Regulator
  KUN2590_RS01300 (SPNIH34_02100) - 238786..239955 (+) 1170 WP_002991122.1 glycosyltransferase family 4 protein -
  KUN2590_RS01305 (SPNIH34_02110) sufC 240077..240847 (+) 771 WP_002986023.1 Fe-S cluster assembly ATPase SufC -
  KUN2590_RS01310 (SPNIH34_02120) sufD 240942..242204 (+) 1263 WP_011054182.1 Fe-S cluster assembly protein SufD -
  KUN2590_RS01315 (SPNIH34_02130) - 242235..243461 (+) 1227 WP_011054183.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 253 a.a.        Molecular weight: 29051.68 Da        Isoelectric Point: 4.1282

>NTDB_id=82660 KUN2590_RS01295 WP_011106593.1 238018..238779(+) (mecA) [Streptococcus pyogenes strain NIH34]
MEMKQISETTLKITISMDDLEERGMELKDFLIPQEKTEEFFYSVMDELDLPDNFKDSGMLSFRVTPRKDRLDVFVTKSEI
NKDINLEDLAEFGDMSQMTPEDFFKSLEQSMREKGDVKAHEKLEQIEEIMEDVVEATLANQSEAADPSTNHESEPLDYVH
YVLDFSTITEAVAFAKTIDFSIEASELYKGSNCYHMTILLDVQQQPSYFANVMYARLIEHANPGSKTRAYLQEHGLQLML
DGAVEQLQKIELG

Nucleotide


Download         Length: 762 bp        

>NTDB_id=82660 KUN2590_RS01295 WP_011106593.1 238018..238779(+) (mecA) [Streptococcus pyogenes strain NIH34]
ATGGAAATGAAACAAATTAGCGAGACAACGCTAAAAATAACAATTAGTATGGACGATTTAGAAGAAAGAGGAATGGAGTT
GAAAGATTTCTTGATTCCTCAAGAAAAAACAGAAGAGTTTTTCTATTCTGTGATGGACGAACTCGATCTTCCAGATAATT
TTAAAGATAGTGGTATGCTTAGTTTTCGAGTGACTCCACGCAAGGACCGTCTAGATGTTTTTGTTACCAAATCTGAGATA
AATAAAGATATTAATCTTGAAGATTTAGCAGAGTTTGGTGATATGTCCCAAATGACTCCGGAAGATTTTTTCAAGAGCTT
GGAGCAATCCATGCGTGAAAAGGGAGATGTCAAAGCTCATGAAAAATTGGAACAAATTGAAGAGATAATGGAAGATGTTG
TTGAAGCCACTCTAGCTAATCAGTCTGAGGCGGCTGATCCATCAACTAATCATGAGTCAGAACCTTTAGACTATGTCCAT
TATGTATTGGATTTTTCAACGATTACAGAGGCAGTGGCTTTTGCTAAAACGATTGATTTTTCGATAGAAGCTTCAGAGTT
ATATAAGGGGAGCAACTGCTACCATATGACTATTTTATTAGATGTTCAGCAACAACCATCTTATTTTGCGAATGTCATGT
ATGCGAGATTGATTGAGCATGCAAACCCTGGATCAAAAACAAGAGCTTATTTACAAGAGCATGGCTTACAATTGATGCTT
GATGGTGCTGTTGAGCAATTACAAAAGATTGAGTTGGGATAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-247)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A5S4TK55

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus mutans UA159

63.2

98.814

0.625
  mecA Streptococcus thermophilus LMD-9

56.225

98.419

0.553
  mecA Streptococcus thermophilus LMG 18311

55.422

98.419

0.545
  mecA Streptococcus pneumoniae Rx1

48.627

100

0.49
  mecA Streptococcus pneumoniae D39

48.627

100

0.49
  mecA Streptococcus pneumoniae R6

48.627

100

0.49
  mecA Streptococcus pneumoniae TIGR4

48.627

100

0.49

Multiple sequence alignment