Detailed information NTG0822264

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: R2B38_RS23285
• Genome accession: NZ_CP137549
• Coordinates: 5190790..5193318 (+)
• Length: 842 a.a.
• NCBI ID: WP_033286115.1
• Uniprot ID: -
• Organism: Streptomyces sp. N50
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 5185790..5198318

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R2B38_RS23250 (R2B38_23250)	-	5186108..5186905 (+)	798	WP_318017984.1	type III pantothenate kinase	-
R2B38_RS23255 (R2B38_23255)	-	5187194..5187856 (+)	663	WP_318021767.1	hypothetical protein	-
R2B38_RS23260 (R2B38_23260)	-	5187905..5188084 (+)	180	WP_033286119.1	hypothetical protein	-
R2B38_RS23265 (R2B38_23265)	-	5188229..5188618 (+)	390	WP_033286118.1	BlaI/MecI/CopY family transcriptional regulator	-
R2B38_RS23270 (R2B38_23270)	-	5188628..5189161 (+)	534	WP_019064250.1	amino-acid N-acetyltransferase	-
R2B38_RS23275 (R2B38_23275)	-	5189386..5189721 (+)	336	WP_033286117.1	histone-like nucleoid-structuring protein Lsr2	-
R2B38_RS23280 (R2B38_23280)	-	5189700..5190347 (-)	648	WP_318017985.1	SCO3374 family protein	-
R2B38_RS23285 (R2B38_23285)	clpC	5190790..5193318 (+)	2529	WP_033286115.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
R2B38_RS23290 (R2B38_23290)	-	5193401..5196439 (-)	3039	WP_318017986.1	NACHT domain-containing protein	-
R2B38_RS23295 (R2B38_23295)	-	5196487..5197092 (-)	606	WP_318017987.1	HAD family acid phosphatase	-
R2B38_RS23300 (R2B38_23300)	-	5197552..5198133 (+)	582	WP_318017988.1	M23 family metallopeptidase	-

Sequence

Protein

• Length: 842 a.a.
• Molecular weight: 92999.19 Da
• Isoelectric Point: 5.8414

>NTDB_id=822264 R2B38_RS23285 WP_033286115.1 5190790..5193318(+) (clpC) [Streptomyces sp. N50]
MFERFTDRARRVVVLAQEEARMLNHNYIGTEHILLGLIHEGEGVAAKALESLGISLEAVRQQVEEIIGQGQQAPSGHIPF
TPRAKKVLELSLREALQLGHNYIGTEHILLGLIREGEGVAAQVLVKLGADLNRVRQQVIQLLSGYQGKETATAGGPAEGT
PSTSLVLDQFGRNLTQAARESKLDPVIGREKEIERVMQVLSRRTKNNPVLIGEPGVGKTAVVEGLAQAIVKGEVPETLKD
KHLYTLDLGALVAGSRYRGDFEERLKKVLKEIRTRGDIILFIDELHTLVGAGAAEGAIDAASILKPMLARGELQTIGATT
LDEYRKHLEKDAALERRFQPIQVAEPSLPHTIEILKGLRDRYEAHHRVSITDEALVQAATLADRYISDRFLPDKAIDLID
EAGSRMRIRRMTAPPDLREFDEKIAGVRRDKESAIDSQDFEKAASLRDKEKQLLAAKAKREKEWKAGDMDVVAEVDGELI
AEVLATATGIPVFKLTEEESSRLLRMEDELHKRVIGQKDAVKALSKAIRRTRAGLKDPKRPGGSFIFAGPSGVGKTELSK
ALAEFLFGDEDALISLDMSEFSEKHTVSRLFGSPPGYVGYEEGGQLTEKVRRKPFSVVLFDEVEKAHPDIFNSLLQILED
GRLTDSQGRVVDFKNTVIIMTTNLGTRDISKGFNLGFAATGDTKSNYERMKNKVSDELKQHFRPEFLNRVDDVVVFPQLT
QDDILQIVDLMVGKVDERLKDRDMGIELSQAAKELLSKKGYDPVLGARPLRRTIQREIEDTLSEKILFGELRPGHIVVVD
VEGEGDAKTFTFRGEEKSALPDVPPIEDAAAGGAGPNLSKEA

Nucleotide

• Length: 2529 bp

>NTDB_id=822264 R2B38_RS23285 WP_033286115.1 5190790..5193318(+) (clpC) [Streptomyces sp. N50]
ATGTTCGAGAGGTTCACCGACCGCGCGCGGCGGGTTGTCGTCCTGGCTCAGGAAGAAGCCCGGATGCTCAACCACAACTA
CATCGGCACCGAGCACATCCTCCTGGGCCTGATCCACGAGGGTGAGGGTGTCGCCGCAAAGGCCCTGGAGAGCCTCGGCA
TTTCGCTTGAGGCGGTCCGCCAGCAGGTTGAGGAGATCATCGGACAGGGCCAGCAGGCACCGTCCGGTCACATCCCCTTC
ACTCCCCGTGCCAAGAAGGTCCTGGAGCTGTCGCTCCGCGAGGCCCTTCAGCTGGGCCACAACTACATCGGCACGGAGCA
CATCCTGCTCGGCCTGATCCGTGAGGGCGAGGGCGTCGCCGCCCAGGTCCTGGTCAAGCTGGGCGCTGATCTCAACCGTG
TGCGGCAGCAGGTGATCCAGCTGCTCTCCGGTTACCAGGGCAAGGAGACCGCCACCGCCGGCGGCCCTGCGGAGGGCACC
CCCTCGACGTCCCTGGTCCTCGACCAGTTCGGCCGGAACCTCACCCAGGCCGCTCGTGAGTCCAAGCTCGACCCGGTCAT
CGGGCGCGAGAAGGAGATCGAGCGGGTCATGCAGGTGCTGTCCCGCCGTACGAAGAACAACCCGGTCCTGATCGGTGAGC
CCGGCGTCGGCAAGACCGCCGTCGTCGAGGGCCTCGCCCAGGCCATCGTCAAGGGCGAGGTGCCCGAGACCCTCAAGGAC
AAGCACCTCTACACCCTGGACCTCGGCGCGCTGGTCGCCGGCTCCCGCTACCGCGGTGACTTCGAGGAGCGCCTGAAGAA
GGTCCTCAAGGAGATCCGCACCCGCGGCGACATCATCCTGTTCATCGACGAGCTGCACACGCTGGTCGGTGCGGGTGCCG
CCGAGGGCGCCATCGACGCCGCTTCGATCCTGAAGCCGATGCTGGCCCGCGGTGAGCTGCAGACCATCGGCGCCACGACG
CTGGACGAGTACCGCAAGCACCTGGAGAAGGACGCGGCCCTCGAGCGCCGCTTCCAGCCCATCCAGGTCGCGGAACCGTC
CCTGCCGCACACCATCGAGATCCTCAAGGGTCTGCGCGACCGCTACGAGGCGCACCACCGTGTCTCCATCACGGACGAGG
CGCTCGTACAGGCCGCCACGCTGGCCGACCGGTACATCTCGGACCGCTTCCTGCCGGACAAGGCGATCGACCTGATCGAC
GAGGCCGGCTCCCGGATGCGCATCCGCCGGATGACCGCGCCGCCGGACCTGCGCGAGTTCGACGAGAAGATCGCCGGCGT
CCGCCGCGACAAGGAGTCCGCGATCGACTCGCAGGACTTCGAGAAGGCCGCCTCCCTGCGCGACAAGGAGAAGCAGCTCC
TGGCCGCCAAGGCCAAGCGGGAGAAGGAGTGGAAGGCCGGCGACATGGACGTCGTGGCCGAGGTCGACGGCGAGCTGATC
GCCGAGGTCCTCGCGACCGCCACCGGCATTCCGGTCTTCAAGCTCACGGAAGAGGAGTCCAGCCGTCTCCTCCGCATGGA
GGACGAGCTCCACAAGCGGGTCATCGGCCAGAAGGACGCCGTCAAGGCGCTCTCGAAGGCGATCCGTCGTACGCGTGCGG
GCCTCAAGGACCCGAAGCGTCCCGGTGGTTCGTTCATCTTCGCCGGTCCGTCCGGTGTCGGTAAGACCGAGCTGTCCAAG
GCGCTCGCGGAGTTCCTCTTCGGTGACGAGGACGCGCTGATCTCCCTCGACATGTCGGAGTTCAGCGAGAAGCACACGGT
GTCGCGGCTCTTCGGTTCGCCCCCCGGTTACGTGGGCTACGAAGAGGGCGGCCAGCTCACGGAGAAGGTCCGTCGCAAGC
CGTTCTCGGTCGTCCTCTTCGACGAGGTCGAGAAGGCCCACCCGGACATCTTCAACAGCCTTCTGCAGATCCTGGAGGAC
GGTCGCCTGACCGACTCCCAGGGCCGGGTCGTGGACTTCAAGAACACGGTCATCATCATGACGACCAACCTTGGAACCCG
TGACATCTCGAAGGGCTTCAACCTGGGCTTCGCGGCCACGGGTGACACGAAGTCCAACTACGAGCGCATGAAGAACAAGG
TCTCGGACGAGCTCAAGCAGCACTTCCGCCCCGAGTTCCTCAACCGTGTCGACGACGTCGTCGTCTTCCCGCAGCTCACC
CAGGACGACATCCTCCAGATCGTCGACCTGATGGTCGGCAAGGTGGACGAGCGCCTCAAGGACCGGGACATGGGCATCGA
GCTCTCCCAGGCCGCGAAGGAGCTCCTCTCCAAGAAGGGTTACGACCCGGTGCTGGGCGCGCGTCCGCTGCGGCGCACGA
TCCAGCGCGAGATCGAGGACACGCTCTCGGAGAAGATCCTCTTCGGCGAGCTGCGTCCCGGTCACATCGTGGTCGTGGAT
GTCGAGGGCGAGGGCGACGCGAAGACCTTCACCTTCCGGGGTGAGGAGAAGTCGGCGCTTCCCGATGTGCCGCCGATCGA
GGATGCTGCGGCTGGTGGCGCGGGTCCGAATTTGAGCAAGGAGGCGTAA

Domains

Predicted by InterProScan.

• ATPase family associated with various cellular activities (AAA) (AAA) (209-329)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (719-799)

• AAA lid domain (AAA_lid_9) (349-449)

• AAA domain (Cdc48 subfamily) (AAA_2) (541-712)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (93-142)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (16-68)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Bacillus subtilis subsp. subtilis str. 168	61.605	96.2	0.593
clpC	Streptococcus mutans UA159	44.217	98.575	0.436
clpC	Streptococcus thermophilus LMD-9	43.147	99.644	0.43
clpC	Streptococcus thermophilus LMG 18311	42.976	99.762	0.429
clpC	Streptococcus pneumoniae Rx1	44.238	95.843	0.424
clpC	Streptococcus pneumoniae D39	44.238	95.843	0.424
clpC	Streptococcus pneumoniae TIGR4	43.99	95.843	0.422
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	43.827	96.2	0.422
clpE	Streptococcus mutans UA159	54.313	74.347	0.404
clpE	Streptococcus pneumoniae TIGR4	52.673	75.534	0.398
clpE	Streptococcus pneumoniae D39	52.516	75.534	0.397
clpE	Streptococcus pneumoniae R6	52.516	75.534	0.397
clpE	Streptococcus pneumoniae Rx1	52.516	75.534	0.397
clpC	Lactococcus lactis subsp. cremoris KW2	53.226	73.634	0.392