Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexA   Type   Machinery gene
Locus tag   R4705_RS04680 Genome accession   NZ_CP137115
Coordinates   861754..864288 (-) Length   844 a.a.
NCBI ID   WP_000963664.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 20614-6     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 856754..869288
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4705_RS04665 patB 857372..859138 (-) 1767 WP_000859864.1 multidrug efflux ABC transporter subunit PatB -
  R4705_RS04670 - 859326..859763 (+) 438 Protein_873 transposase -
  R4705_RS04675 patA 859913..861607 (-) 1695 WP_000908154.1 multidrug efflux ABC transporter subunit PatA -
  R4705_RS04680 hexA 861754..864288 (-) 2535 WP_000963664.1 DNA mismatch repair protein MutS Machinery gene
  R4705_RS04685 argR 864339..864785 (-) 447 WP_001231472.1 arginine repressor -
  R4705_RS04690 argS 864921..866612 (+) 1692 WP_001092701.1 arginine--tRNA ligase -
  R4705_RS04695 - 867002..867559 (-) 558 Protein_878 transposase -
  R4705_RS04700 - 867545..868030 (+) 486 WP_001821625.1 cupin domain-containing protein -
  R4705_RS04705 - 868114..868821 (+) 708 WP_000166477.1 response regulator transcription factor -

Sequence

Protein


Download         Length: 844 a.a.        Molecular weight: 94843.34 Da        Isoelectric Point: 4.8531

>NTDB_id=820227 R4705_RS04680 WP_000963664.1 861754..864288(-) (hexA) [Streptococcus pneumoniae strain 20614-6]
MAIEKLSPGMQQYVDIKKQYPDAFLLFRMGDFYELFYEDAVNAAQILEISLTSRNKNADNPIPMAGVPYHSAQQYIDVLI
EQGYKVAIAEQMEDPKQAVGVVKREVVQVITPGTVVDSSKPDSQNNFLVAIDREGNQFGLAYMDLVTGDFYVTGLLDFTL
VCGEIRNLKAREVVLGYDLSEEEEQILSRQMNLVLSYEKESFEDLHLLDLRLATVEQTASSKLLQYVHRTQMRELNHLKP
VIRYEIKDFLQMDYATKASLDLVENARSGKKQGSLFWLLDETKTAMGMRLLRSWIHRPLIDKERIVQRQEVVQVFLDHFF
ERSDLTDSLKGVYDIERLASRVSFGKTNPKDLLQLATTLSSVPRIRAILEGMEQPALAYLIAQLDAIPELESLISAAIAP
EAPHVITDGGIIRTGFDETLDKYRCVLREGTSWIAEIEAKERENSGISTLKIDYNKKDGYYFHVTNSQLGNVPAHFFRKA
TLKNSERFGTEELARIEGDMLEAREESANLEYEIFMRIREEVGKYIQRLQALAQGIATVDVLQSLAVVAETQYLIRPEFG
DDSQIDIRKGRHAVVEKVMGAQTYIPNTIQMAEDTSIQLITGPNMSGKSTYMRQLAMTAVMAQLGSYVPAESAHLPIFDA
IFTRIGAADDLVSGQSTFMVEMMEANNAISHATKNSLILFDELGRGTATYDGMALAQSIIEYIHEHIGAKTLFATHYHEL
TSLESSLQHLVNVHVATLEQDGQVTFLHKIEPGPADKSYGIHVAKIAGLPADLLARADKILTQLENQGTESPPPMRQTSA
VTEQISLFDRAEEHPILAELAKLDVYNMTPMQVMNVLVELKQKL

Nucleotide


Download         Length: 2535 bp        

>NTDB_id=820227 R4705_RS04680 WP_000963664.1 861754..864288(-) (hexA) [Streptococcus pneumoniae strain 20614-6]
ATGGCGATAGAAAAGCTATCACCCGGCATGCAACAGTATGTGGATATTAAAAAGCAATATCCAGATGCTTTTTTACTCTT
TCGGATGGGTGATTTTTATGAATTATTTTATGAGGATGCGGTCAATGCTGCGCAGATTCTGGAAATTTCCTTAACGAGTC
GCAACAAGAATGCCGACAATCCGATCCCTATGGCGGGTGTTCCCTATCATTCTGCCCAACAGTATATCGATGTCTTGATT
GAGCAGGGTTATAAGGTGGCTATCGCAGAGCAGATGGAAGATCCTAAACAAGCAGTTGGGGTTGTTAAACGAGAGGTTGT
TCAGGTCATTACGCCAGGGACAGTGGTCGATAGCAGTAAGCCGGACAGTCAGAATAATTTTTTGGTTGCCATAGACCGCG
AAGGCAATCAATTTGGTCTAGCTTATATGGATTTGGTGACGGGTGACTTTTATGTGACAGGTCTTTTGGATTTCACGCTG
GTTTGTGGGGAAATCCGTAACCTCAAGGCTCGAGAAGTGGTGTTGGGTTATGACTTGTCTGAGGAAGAAGAACAAATCCT
CAGCCGCCAGATGAATCTGGTACTCTCTTATGAAAAAGAAAGCTTTGAAGACCTTCATTTATTGGATTTGCGATTGGCAA
CGGTGGAGCAAACGGCATCTAGTAAGCTGCTCCAGTATGTTCATCGGACTCAGATGAGGGAATTGAACCACCTCAAACCT
GTTATCCGCTACGAAATTAAGGATTTCTTGCAGATGGATTATGCGACCAAGGCTAGTCTGGATTTGGTTGAGAATGCTCG
CTCAGGTAAGAAACAAGGCAGTCTTTTCTGGCTTTTGGATGAAACCAAAACGGCTATGGGGATGCGTCTCTTGCGTTCTT
GGATTCATCGCCCCTTGATTGATAAGGAACGAATCGTCCAACGTCAAGAAGTGGTGCAGGTCTTTCTCGACCATTTCTTT
GAGCGTAGTGACTTGACAGACAGTCTCAAGGGTGTTTATGACATTGAGCGCTTGGCTAGTCGTGTTTCTTTTGGCAAAAC
CAATCCAAAGGATCTCTTGCAGTTGGCGACTACCTTGTCTAGTGTGCCACGGATTCGTGCGATTTTAGAAGGGATGGAGC
AACCTGCTCTAGCCTATCTCATTGCACAACTGGATGCAATCCCTGAGTTGGAGAGTTTGATTAGCGCAGCGATTGCTCCT
GAAGCTCCTCATGTGATTACAGATGGGGGAATTATCCGGACTGGATTTGATGAGACTTTAGACAAGTATCGTTGCGTTCT
CAGAGAAGGGACTAGCTGGATTGCTGAGATTGAGGCTAAGGAGCGAGAAAACTCTGGTATCAGCACGCTCAAGATTGACT
ACAATAAAAAGGATGGCTACTATTTTCATGTGACCAATTCGCAACTGGGAAATGTGCCAGCCCACTTTTTCCGCAAGGCG
ACGCTGAAAAACTCAGAACGCTTTGGAACCGAAGAATTAGCCCGTATCGAGGGAGATATGCTTGAGGCGCGTGAGGAGTC
AGCCAACCTCGAATACGAAATATTTATGCGCATTCGTGAAGAGGTCGGCAAGTACATCCAGCGTTTACAAGCTCTAGCCC
AAGGAATTGCGACGGTTGATGTCTTACAGAGTCTGGCGGTTGTGGCTGAAACCCAGTATTTGATTCGACCTGAGTTTGGT
GACGATTCACAAATTGATATTCGGAAAGGGCGCCATGCTGTCGTTGAAAAGGTTATGGGGGCTCAGACCTATATTCCAAA
TACGATTCAGATGGCAGAAGATACCAGTATTCAACTGATTACAGGGCCAAACATGAGTGGGAAGTCTACCTATATGCGTC
AGTTAGCCATGACGGCGGTTATGGCCCAGCTGGGTTCCTATGTTCCTGCTGAAAGCGCCCATTTACCGATTTTTGATGCG
ATTTTTACCCGTATCGGAGCAGCAGATGACTTGGTTTCGGGTCAGTCAACCTTTATGGTGGAGATGATGGAGGCCAATAA
TGCCATTTCGCATGCGACCAAGAACTCTCTCATTCTCTTTGATGAATTGGGACGTGGAACTGCAACTTATGACGGGATGG
CTCTTGCTCAGTCCATCATCGAATATATCCATGAGCACATCGGAGCTAAGACCCTCTTTGCGACCCACTACCATGAGTTG
ACTAGTCTGGAGTCTAGTTTACAACACTTGGTCAATGTCCACGTGGCAACTTTGGAGCAGGATGGGCAGGTCACCTTCCT
TCACAAGATTGAACCGGGACCAGCTGATAAATCCTACGGTATCCATGTTGCCAAGATTGCTGGCTTGCCAGCAGACCTTT
TAGCAAGGGCGGATAAGATTTTGACTCAGCTAGAGAATCAAGGAACAGAGAGTCCTCCTCCCATGAGACAAACTAGTGCT
GTCACTGAACAGATTTCACTCTTTGATAGGGCAGAAGAGCATCCTATCCTAGCAGAATTAGCTAAACTGGATGTGTATAA
TATGACACCTATGCAGGTTATGAATGTCTTAGTAGAGTTAAAACAGAAACTATAA

Domains

Predicted by InterProScan.

MutS family domain IV (MutS_IV)

(415-506)

MutS domain III (MutS_III)

(256-546)

MutS domain I (MutS_I)

(8-118)

MutS domain II (MutS_II)

(126-239)

MutS domain V (MutS_V)

(599-785)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexA Streptococcus pneumoniae R6

99.408

100

0.994
  mutS Pseudomonas stutzeri strain ATCC 17587

36.651

100

0.371