Detailed information NTG0820133

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: R4701_RS06775
• Genome accession: NZ_CP137114
• Coordinates: 1328640..1329677 (+)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0H2URQ4
• Organism: Streptococcus pneumoniae strain 15P3054
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1323640..1334677

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R4701_RS06740	yidC	1323675..1324601 (-)	927	WP_000835941.1	membrane protein insertase YidC	-
R4701_RS06745	-	1324679..1324957 (-)	279	WP_001174613.1	acylphosphatase	-
R4701_RS06750	-	1324991..1325731 (+)	741	WP_000152700.1	RNA methyltransferase	-
R4701_RS06755	-	1325787..1326470 (+)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
R4701_RS06760	asnA	1326582..1327574 (+)	993	WP_000747993.1	aspartate--ammonia ligase	-
R4701_RS06765	rsmD	1327639..1328178 (+)	540	WP_000706963.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
R4701_RS06770	coaD	1328168..1328656 (+)	489	WP_317805813.1	pantetheine-phosphate adenylyltransferase	-
R4701_RS06775	sepM	1328640..1329677 (+)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
R4701_RS06780	-	1329735..1329965 (+)	231	WP_000250384.1	DUF1146 family protein	-
R4701_RS06785	murA	1329989..1331272 (+)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
R4701_RS06790	-	1331265..1331453 (+)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
R4701_RS06795	endA	1331492..1332316 (+)	825	WP_001036779.1	DNA-entry nuclease EndA	Machinery gene
R4701_RS06800	-	1332607..1333938 (+)	1332	WP_000390039.1	hemolysin family protein	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=820133 R4701_RS06775 WP_000727277.1 1328640..1329677(+) (sepM) [Streptococcus pneumoniae strain 15P3054]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=820133 R4701_RS06775 WP_000727277.1 1328640..1329677(+) (sepM) [Streptococcus pneumoniae strain 15P3054]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAAATCATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGTCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterProScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0H2URQ4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591