Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   R4700_RS09305 Genome accession   NZ_CP137112
Coordinates   1812034..1814292 (-) Length   752 a.a.
NCBI ID   WP_288160673.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 02H2025     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1807034..1819292
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4700_RS09285 tnpB 1809484..1809720 (-) 237 WP_000973006.1 IS66 family insertion sequence element accessory protein TnpB -
  R4700_RS09290 - 1809981..1810280 (-) 300 WP_000767195.1 DUF1827 family protein -
  R4700_RS09295 - 1810445..1810867 (-) 423 WP_001814211.1 NUDIX hydrolase -
  R4700_RS09300 - 1810978..1811827 (+) 850 Protein_1792 IS630 family transposase -
  R4700_RS09305 clpE 1812034..1814292 (-) 2259 WP_288160673.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  R4700_RS09310 - 1814521..1814751 (-) 231 WP_000443573.1 YkuJ family protein -
  R4700_RS09315 - 1814941..1815624 (+) 684 WP_001011637.1 amino acid ABC transporter permease -
  R4700_RS09320 - 1815624..1816358 (+) 735 WP_000140949.1 amino acid ABC transporter ATP-binding protein -
  R4700_RS09325 - 1816512..1817369 (+) 858 WP_277771012.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  R4700_RS09330 - 1817511..1818383 (+) 873 WP_000864683.1 NAD(P)H-hydrate dehydratase -

Sequence

Protein


Download         Length: 752 a.a.        Molecular weight: 83820.32 Da        Isoelectric Point: 5.4566

>NTDB_id=819922 R4700_RS09305 WP_288160673.1 1812034..1814292(-) (clpE) [Streptococcus pneumoniae strain 02H2025]
MLCQNCKINDSTIHLYTNINGKQKQIDLCQNCYKIIKTDPKNGLFKGMTDLNNRDFDPFGDFFNDLNNFRPSSNPPPIPP
TQSGGGYGGNGGYGSQNRGSAQTPPPSQEKGLLEEFGINVTEIARRGDIDPVIGRDDEIIRVIEILNRRTKNNPVLIGEP
GVGKTAVVEGLAQKIVDGDVPHKLQGKQVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRKREDIILFIDEIHEIVGAGSA
SDGNMDAGNILKPALARGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPTVDETITILKGIQKKYEDYHHVQYTDAA
IEAAATLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKVIDQRLIEAENLKSQATREEDFEKAAYFRDQIAKYKEM
QKKKITDQDTPIISEKTIEHIIEQKTNIPVGDLKEKEQSQLIHLAEDLKSHVIGQDDAVDKIAKAIRRNRVGLGTPNRPI
GSFLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHSVAKLVGAPPGYVGYDEAGQLTEKVRHNPYSLILLDE
VEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDAIIIMTSNAGTGKTEASVGFGAAREGRTNSVLGELGNFFSPEFMNRF
DGIIEFKALSKDNLLQIVELMLADVNKRLSSNNIRLDVTDKVKEKLVDLGYDPKMGARPLRRTIQDYIEDTITDYYLENP
SEKDLKAVMTSKGNIQIKSAKKAEVKSSEKEK

Nucleotide


Download         Length: 2259 bp        

>NTDB_id=819922 R4700_RS09305 WP_288160673.1 1812034..1814292(-) (clpE) [Streptococcus pneumoniae strain 02H2025]
ATGCTTTGTCAAAACTGTAAAATTAACGACTCAACAATTCATCTTTACACCAATATCAATGGAAAACAAAAACAAATTGA
CCTCTGTCAAAACTGCTATAAGATTATCAAAACAGATCCTAAGAATGGCCTCTTCAAAGGTATGACGGATCTGAACAATC
GTGACTTCGATCCCTTTGGTGATTTCTTCAATGATCTAAACAATTTCAGACCTTCTAGCAATCCTCCTCCTATTCCCCCA
ACCCAATCAGGTGGAGGTTACGGTGGAAACGGCGGTTATGGTTCCCAAAATCGTGGATCTGCTCAAACTCCGCCACCTAG
CCAAGAAAAAGGCCTGCTGGAAGAATTTGGTATTAATGTAACTGAAATTGCCCGTCGTGGAGACATTGACCCCGTTATTG
GGCGTGACGATGAGATTATCCGTGTCATCGAGATTCTCAATCGTAGAACCAAGAATAATCCTGTCCTTATCGGTGAACCT
GGTGTCGGAAAAACGGCCGTTGTCGAAGGTCTAGCTCAGAAAATTGTCGATGGCGATGTGCCACATAAACTCCAAGGTAA
ACAAGTCATCCGTCTGGATGTGGTTAGCTTAGTTCAAGGAACGGGGATTCGAGGACAATTTGAAGAACGCATGCAAAAAC
TCATGGAAGAAATTCGCAAACGTGAAGACATCATCCTCTTTATCGATGAAATCCATGAAATTGTTGGTGCTGGTTCTGCG
AGTGATGGTAATATGGACGCAGGAAATATCCTCAAGCCAGCCCTTGCTCGTGGAGAACTGCAACTAGTCGGTGCTACTAC
CCTCAATGAATACCGTATCATTGAAAAGGATGCTGCCCTCGAGCGTCGTATGCAGCCTGTTAAAGTCGATGAACCAACGG
TGGATGAAACAATCACTATTCTCAAAGGGATTCAAAAGAAATACGAAGATTACCACCACGTTCAATATACCGATGCTGCG
ATTGAAGCAGCTGCAACTCTTTCCAATCGCTACATCCAAGATCGCTTCTTGCCTGACAAGGCCATTGACCTCCTAGATGA
AGCTGGTTCTAAGATGAACTTGACCTTGAATTTTGTGGATCCTAAAGTAATTGATCAGCGCTTGATTGAGGCTGAAAATC
TCAAGTCTCAAGCTACACGAGAAGAAGATTTTGAGAAGGCGGCCTACTTCCGCGACCAGATTGCCAAGTATAAGGAAATG
CAAAAGAAAAAGATCACAGACCAGGATACTCCTATCATCAGCGAGAAAACTATTGAGCACATTATCGAGCAGAAAACCAA
TATCCCTGTTGGTGATTTGAAAGAGAAAGAACAATCTCAACTCATCCATCTAGCCGAAGATCTCAAGTCTCATGTTATTG
GCCAAGATGATGCAGTCGATAAGATTGCCAAGGCTATTCGCCGTAATCGTGTCGGACTTGGTACCCCTAACCGCCCAATC
GGAAGCTTCCTCTTCGTTGGGCCAACTGGTGTCGGTAAGACAGAACTTTCCAAACAACTGGCTATCGAACTTTTTGGTTC
TGCTGATAGTATGATTCGCTTTGATATGAGTGAATACATGGAAAAACATAGTGTGGCTAAGTTGGTCGGCGCCCCTCCAG
GTTATGTTGGCTATGATGAGGCTGGTCAATTAACTGAAAAAGTTCGCCACAATCCATATTCTCTCATCCTTCTCGATGAA
GTGGAAAAAGCTCACCCAGATGTTATGCACATGTTTCTTCAAGTCTTGGACGATGGTCGTTTGACAGACGGGCAAGGACG
CACCGTTAGCTTCAAGGATGCCATCATTATCATGACCTCAAATGCAGGTACAGGAAAGACCGAAGCTAGCGTTGGATTTG
GTGCTGCTAGAGAAGGACGTACCAATTCTGTCCTCGGTGAACTCGGTAACTTCTTTAGCCCAGAGTTTATGAACCGTTTT
GATGGCATTATCGAATTTAAGGCTCTCAGCAAGGATAACCTCCTTCAGATTGTCGAGCTCATGCTAGCAGATGTTAACAA
GCGCCTCTCTAGCAACAACATTCGTTTGGATGTAACTGATAAGGTCAAGGAAAAGTTGGTTGACCTAGGTTATGATCCAA
AAATGGGAGCACGCCCACTTCGTCGGACTATTCAAGACTATATTGAGGACACAATCACTGACTACTACCTTGAAAATCCA
AGCGAAAAAGATCTCAAAGCAGTTATGACTAGCAAGGGAAACATTCAGATTAAATCTGCCAAAAAAGCTGAAGTTAAAAG
TTCTGAAAAAGAAAAATAA

Domains

Predicted by InterProScan.

AAA lid domain (AAA_lid_9)

(293-390)

ATPase family associated with various cellular activities (AAA) (AAA)

(155-276)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(649-723)

AAA domain (Cdc48 subfamily) (AAA_2)

(478-641)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

99.468

100

0.995
  clpE Streptococcus pneumoniae D39

99.468

100

0.995
  clpE Streptococcus pneumoniae R6

99.468

100

0.995
  clpE Streptococcus pneumoniae TIGR4

99.335

100

0.993
  clpE Streptococcus mutans UA159

82.865

99.335

0.823
  clpC Lactococcus lactis subsp. cremoris KW2

76.776

97.34

0.747
  clpC Bacillus subtilis subsp. subtilis str. 168

52.308

86.436

0.452
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

47.687

83.378

0.398
  clpC Streptococcus pneumoniae TIGR4

46.91

83.91

0.394
  clpC Streptococcus pneumoniae Rx1

46.91

83.91

0.394
  clpC Streptococcus pneumoniae D39

46.91

83.91

0.394
  clpC Streptococcus thermophilus LMD-9

46.795

82.979

0.388
  clpC Streptococcus mutans UA159

46.571

83.378

0.388
  clpC Streptococcus thermophilus LMG 18311

46.4

83.112

0.386