Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/blpH   Type   Regulator
Locus tag   R4700_RS08035 Genome accession   NZ_CP137112
Coordinates   1562341..1563681 (+) Length   446 a.a.
NCBI ID   WP_277770850.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 02H2025     
Function   phosphorylation of ComE; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1557341..1568681
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4700_RS07995 - 1557564..1557740 (-) 177 WP_277770848.1 hypothetical protein -
  R4700_RS08000 - 1557922..1558209 (-) 288 WP_000777760.1 hypothetical protein -
  R4700_RS08005 - 1558219..1558629 (-) 411 WP_001278301.1 HIT family protein -
  R4700_RS08010 pptA 1558697..1559428 (+) 732 WP_001866897.1 ABC transporter ATP-binding protein Regulator
  R4700_RS08015 pptB 1559425..1560474 (+) 1050 WP_288160555.1 ABC transporter permease Regulator
  R4700_RS08020 - 1560642..1560971 (-) 330 WP_088795779.1 helicase BlpT -
  R4700_RS08025 - 1561247..1561585 (+) 339 WP_000682121.1 LytTR family DNA-binding domain-containing protein -
  R4700_RS08030 comE/blpR 1561590..1562327 (+) 738 WP_001219126.1 response regulator transcription factor Regulator
  R4700_RS08035 comD/blpH 1562341..1563681 (+) 1341 WP_277770850.1 sensor histidine kinase Regulator
  R4700_RS08040 blpC 1563752..1563880 (-) 129 WP_000358815.1 quorum-sensing system pheromone BlpC -
  R4700_RS08045 - 1563937..1565298 (-) 1362 WP_277770851.1 bacteriocin secretion accessory protein -
  R4700_RS11130 blpA 1565309..1567466 (-) 2158 Protein_1543 peptide cleavage/export ABC transporter BlpA -
  R4700_RS08065 blpM 1567768..1568022 (+) 255 WP_277770852.1 two-peptide bacteriocin subunit BlpM -
  R4700_RS08070 blpN 1568038..1568241 (+) 204 WP_001099490.1 two-peptide bacteriocin subunit BlpN -
  R4700_RS08075 cipB 1568485..1568634 (+) 150 WP_001809846.1 bacteriocin-like peptide BlpO Regulator

Sequence

Protein


Download         Length: 446 a.a.        Molecular weight: 51722.49 Da        Isoelectric Point: 5.2266

>NTDB_id=819910 R4700_RS08035 WP_277770850.1 1562341..1563681(+) (comD/blpH) [Streptococcus pneumoniae strain 02H2025]
MNIAWILLYALVINGLEIVIFFKVDGIGLTFDRIFKAFLFKILLAFVFVMISYIVGNVYLSYFMEPLYGIGLSFLLLRGL
PKKILIFYGLFPMILVELFYRGVSYFVLPFLGQGIVDGDGNPIFLLIMIFVCFIVLVFLKWLDYDFTRLRREFLDTGFQK
SLTKINWAMGAYYLVMQSLSYLEYEQGIQSTTVRHLILVFYLLFFMGGIKKLDTYLKEKLQEELNQEQTLRYRDMERYSR
HIEELYKEIRSFRHDYTNLLTSLRLGIEEEDMEQIKEIYDSVLRDSSQKLQDNKYDLGRLVNIRDRALKSLLAGKFIKAR
EKNIVFNVEVPEEIQVEGMSLLDFLTIVSILCDNAIEASVEASQPHVSIAFLKNGAQETFIIENSIKEEGIDISEIFSFG
ASSKGEERGVGLYTVMKIVESHPNTSLNTTCQNQVFRQVLTVIHTE

Nucleotide


Download         Length: 1341 bp        

>NTDB_id=819910 R4700_RS08035 WP_277770850.1 1562341..1563681(+) (comD/blpH) [Streptococcus pneumoniae strain 02H2025]
ATGAACATTGCTTGGATATTGTTGTATGCACTTGTTATTAATGGACTAGAAATTGTCATTTTCTTTAAAGTAGATGGAAT
TGGTCTCACTTTCGATAGAATTTTTAAGGCCTTTCTTTTTAAGATACTGTTGGCCTTTGTTTTTGTGATGATTAGCTATA
TAGTAGGAAATGTTTACCTATCTTATTTTATGGAACCCTTGTACGGCATAGGTCTATCTTTCTTATTGTTAAGAGGGCTT
CCTAAAAAAATCCTTATTTTTTATGGTCTCTTCCCAATGATATTAGTAGAGCTCTTTTACAGAGGTGTTTCCTATTTTGT
GCTTCCATTTTTGGGGCAAGGAATTGTAGATGGGGATGGCAATCCTATCTTTTTATTGATTATGATATTCGTTTGCTTCA
TAGTTTTAGTCTTTTTGAAATGGTTAGACTATGATTTCACTAGATTGAGAAGGGAGTTTCTAGATACAGGTTTTCAAAAG
TCTCTTACTAAGATTAACTGGGCAATGGGGGCTTATTATCTAGTGATGCAAAGTCTATCTTACCTTGAATATGAACAAGG
TATTCAATCAACGACTGTTCGCCATCTCATCCTAGTGTTTTACCTACTCTTTTTTATGGGGGGTATCAAGAAATTGGATA
CCTATTTGAAGGAAAAACTTCAGGAGGAACTGAACCAAGAGCAGACCTTGCGCTACAGAGATATGGAACGCTATAGTCGG
CATATAGAGGAACTTTACAAGGAAATTCGGAGTTTTCGCCATGACTACACTAACCTCTTAACCAGCTTACGTTTGGGCAT
TGAAGAGGAGGATATGGAGCAGATAAAAGAGATCTACGACTCGGTCTTAAGGGATTCCAGTCAGAAATTGCAGGACAATA
AATATGACCTGGGCAGATTGGTGAATATTCGTGACCGTGCCCTCAAGAGTCTCCTAGCTGGAAAATTTATAAAAGCTAGA
GAAAAGAACATTGTCTTTAATGTTGAAGTTCCTGAGGAGATTCAGGTTGAGGGGATGAGCCTACTTGATTTTCTAACCAT
TGTGTCTATCCTTTGTGACAATGCTATTGAAGCCAGTGTGGAAGCTAGTCAACCTCATGTTTCAATCGCCTTTTTAAAAA
ATGGAGCACAGGAGACCTTTATCATCGAAAACTCCATCAAAGAAGAGGGCATCGATATTTCTGAAATCTTCTCCTTTGGA
GCCAGTTCTAAAGGGGAGGAGAGAGGAGTTGGTCTCTATACCGTCATGAAGATTGTGGAAAGCCATCCTAATACCAGTCT
AAATACCACCTGTCAAAATCAAGTCTTTCGTCAGGTACTTACTGTGATACATACAGAATGA

Domains

Predicted by InterProScan.

GHKL domain (HATPase_c_5)

(340-440)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/blpH Streptococcus mutans UA159

42.065

89.013

0.374