Detailed information NTG0819463

Bioinformatically predicted

Overview

• Name: ccrA
• Type: Machinery gene
• Locus tag: QAY80_RS12975
• Genome accession: NZ_CP123142
• Coordinates: 2616137..2617486 (+)
• Length: 449 a.a.
• NCBI ID: WP_000815646.1
• Uniprot ID: Q9XB96
• Organism: Staphylococcus aureus strain GE-MRSA21
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	2616137..2637502	2616137..2617486	within	0

Gene organization within MGE regions

Location: 2616137..2637502

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QAY80_RS12975 (QAY80_12965)	ccrA	2616137..2617486 (+)	1350	WP_000815646.1	cassette chromosome recombinase CcrA	Machinery gene
QAY80_RS12980 (QAY80_12970)	ccrB	2617508..2619136 (+)	1629	WP_001186602.1	cassette chromosome recombinase CcrB	Machinery gene
QAY80_RS12985 (QAY80_12975)	-	2619654..2620004 (+)	351	WP_000859155.1	SAUGI family uracil-DNA glycosylase inhibitor	-
QAY80_RS12990 (QAY80_12980)	-	2620091..2620402 (+)	312	WP_000700853.1	DUF960 family protein	-
QAY80_RS12995 (QAY80_12985)	-	2620420..2620926 (+)	507	WP_001092169.1	DUF1643 domain-containing protein	-
QAY80_RS13000 (QAY80_12990)	-	2620947..2621264 (+)	318	WP_000659050.1	JAB domain-containing protein	-
QAY80_RS13005 (QAY80_12995)	-	2621383..2622468 (+)	1086	WP_000868132.1	tyrosine-type recombinase/integrase	-
QAY80_RS13010 (QAY80_13000)	-	2622465..2624357 (+)	1893	WP_001557544.1	site-specific integrase	-
QAY80_RS13015 (QAY80_13005)	-	2624364..2624741 (+)	378	WP_000361059.1	DUF6262 family protein	-
QAY80_RS13020 (QAY80_13010)	-	2624892..2625674 (+)	783	WP_000067268.1	aminoglycoside nucleotidyltransferase ANT(9)-Ia	-
QAY80_RS13025 (QAY80_13015)	erm(A)	2625800..2626531 (-)	732	WP_001072201.1	23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A)	-
QAY80_RS13030	-	2626614..2626673 (-)	60	WP_010959190.1	erythromycin resistance leader peptide	-
QAY80_RS13035 (QAY80_13020)	-	2627065..2627727 (+)	663	WP_001092058.1	class I SAM-dependent methyltransferase	-
QAY80_RS13040 (QAY80_13025)	-	2628072..2628710 (-)	639	Protein_2527	sulfite exporter TauE/SafE family protein	-
QAY80_RS13045 (QAY80_13030)	cstR	2628710..2628970 (-)	261	WP_000220507.1	persulfide-sensing transcriptional repressor CstR	-
QAY80_RS13050 (QAY80_13035)	-	2629106..2630170 (+)	1065	WP_000438836.1	DsrE/DsrF/DrsH-like family protein	-
QAY80_RS13055 (QAY80_13040)	cstB	2630203..2631537 (+)	1335	Protein_2530	persulfide dioxygenase-sulfurtransferase CstB	-
QAY80_RS13060 (QAY80_13045)	-	2631651..2632760 (-)	1110	WP_000943131.1	ROK family transcriptional regulator	-
QAY80_RS13065 (QAY80_13050)	psm-mec	2633115..2633183 (+)	69	WP_014532405.1	phenol-soluble modulin PSM-mec	-
QAY80_RS13070 (QAY80_13055)	mecI	2633268..2633639 (-)	372	WP_000369214.1	mecA-type methicillin resistance repressor MecI	-
QAY80_RS13075 (QAY80_13060)	mecR1	2633639..2635396 (-)	1758	WP_000952923.1	beta-lactam sensor/signal transducer MecR1	-
QAY80_RS13080 (QAY80_13065)	mecA	2635493..2637502 (+)	2010	WP_001801873.1	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 52607.20 Da
• Isoelectric Point: 9.9585

>NTDB_id=819463 QAY80_RS12975 WP_000815646.1 2616137..2617486(+) (ccrA) [Staphylococcus aureus strain GE-MRSA21]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide

• Length: 1350 bp

>NTDB_id=819463 QAY80_RS12975 WP_000815646.1 2616137..2617486(+) (ccrA) [Staphylococcus aureus strain GE-MRSA21]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

• Recombinase (Recombinase) (169-250)

• Recombinase zinc beta ribbon domain (Zn_ribbon_recom) (262-322)

• Resolvase, N terminal domain (Resolvase) (4-147)

3D structure

• AlphaFold DB: Q9XB96

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrA	Staphylococcus aureus N315	100	100	1
ccrA	Staphylococcus aureus COL	74.833	100	0.748