Detailed information NTG0819254

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: QAY72_RS00465
• Genome accession: NZ_CP123132
• Coordinates: 81380..82423 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain GE-MSSA28
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 76380..87423

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QAY72_RS00435 (QAY72_00430)	-	76691..76801 (+)	111	WP_001790257.1	hypothetical protein	-
QAY72_RS00440 (QAY72_00435)	-	76830..77243 (+)	414	WP_001549145.1	hypothetical protein	-
QAY72_RS00445 (QAY72_00440)	-	77733..78719 (-)	987	WP_000999713.1	FUSC family protein	-
QAY72_RS00450 (QAY72_00445)	map	79306..80064 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
QAY72_RS00455 (QAY72_00450)	-	80281..80667 (+)	387	WP_001110179.1	hypothetical protein	-
QAY72_RS00460 (QAY72_00455)	liaF	80682..81383 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
QAY72_RS00465 (QAY72_00460)	vraS	81380..82423 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
QAY72_RS00470 (QAY72_00465)	vraR	82413..83042 (+)	630	WP_088607876.1	two-component system response regulator VraR	Regulator
QAY72_RS00475 (QAY72_00470)	-	83157..84374 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
QAY72_RS00480 (QAY72_00475)	-	84652..84927 (-)	276	WP_070002542.1	YtxH domain-containing protein	-
QAY72_RS00485 (QAY72_00480)	-	84934..85398 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
QAY72_RS00490 (QAY72_00485)	-	85545..85745 (+)	201	WP_000180461.1	DUF1128 family protein	-
QAY72_RS00495 (QAY72_00490)	-	85748..87004 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=819254 QAY72_RS00465 WP_001017131.1 81380..82423(+) (vraS) [Staphylococcus aureus strain GE-MSSA28]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=819254 QAY72_RS00465 WP_001017131.1 81380..82423(+) (vraS) [Staphylococcus aureus strain GE-MSSA28]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1