Detailed information NTG0819226

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: QAO23_RS06590
• Genome accession: NZ_CP123130
• Coordinates: 1372974..1374017 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain GE-MSSA29
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1367974..1379017

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QAO23_RS06560 (QAO23_06570)	-	1368400..1368510 (+)	111	WP_001790257.1	hypothetical protein	-
QAO23_RS06565 (QAO23_06575)	-	1368539..1368952 (+)	414	WP_025174552.1	hypothetical protein	-
QAO23_RS06570 (QAO23_06580)	-	1369385..1370371 (-)	987	WP_411896788.1	FUSC family protein	-
QAO23_RS06575 (QAO23_06585)	map	1370900..1371658 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
QAO23_RS06580 (QAO23_06590)	-	1371875..1372261 (+)	387	WP_001110179.1	hypothetical protein	-
QAO23_RS06585 (QAO23_06595)	liaF	1372276..1372977 (+)	702	WP_031919966.1	cell wall-active antibiotics response protein LiaF	-
QAO23_RS06590 (QAO23_06600)	vraS	1372974..1374017 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
QAO23_RS06595 (QAO23_06605)	vraR	1374007..1374636 (+)	630	WP_000153526.1	two-component system response regulator VraR	Regulator
QAO23_RS06600 (QAO23_06610)	-	1374749..1375966 (-)	1218	WP_000037087.1	YihY/virulence factor BrkB family protein	-
QAO23_RS06605 (QAO23_06615)	-	1376244..1376519 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
QAO23_RS06610 (QAO23_06620)	-	1376526..1376990 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
QAO23_RS06615 (QAO23_06625)	-	1377137..1377337 (+)	201	WP_000180460.1	DUF1128 family protein	-
QAO23_RS06620 (QAO23_06630)	-	1377340..1378596 (+)	1257	WP_078065149.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=819226 QAO23_RS06590 WP_001017131.1 1372974..1374017(+) (vraS) [Staphylococcus aureus strain GE-MSSA29]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=819226 QAO23_RS06590 WP_001017131.1 1372974..1374017(+) (vraS) [Staphylococcus aureus strain GE-MSSA29]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGTATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAACGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGATCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1