Detailed information NTG0819129

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: QAO33_RS12895
• Genome accession: NZ_CP123123
• Coordinates: 2643322..2644365 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain GE-MSSA33
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2638322..2649365

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QAO33_RS12865 (QAO33_12860)	-	2638740..2639996 (-)	1257	WP_001789555.1	aminopeptidase	-
QAO33_RS12870 (QAO33_12865)	-	2639999..2640199 (-)	201	WP_000180460.1	DUF1128 family protein	-
QAO33_RS12875 (QAO33_12870)	-	2640346..2640810 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
QAO33_RS12880 (QAO33_12875)	-	2640817..2641092 (+)	276	WP_000428171.1	hypothetical protein	-
QAO33_RS12885 (QAO33_12880)	-	2641370..2642587 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
QAO33_RS12890 (QAO33_12885)	vraR	2642703..2643332 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
QAO33_RS12895 (QAO33_12890)	vraS	2643322..2644365 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
QAO33_RS12900 (QAO33_12895)	liaF	2644362..2645063 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
QAO33_RS12905 (QAO33_12900)	-	2645078..2645464 (-)	387	WP_001110179.1	hypothetical protein	-
QAO33_RS12910 (QAO33_12905)	map	2645681..2646439 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
QAO33_RS12915 (QAO33_12910)	-	2646970..2647956 (+)	987	WP_000999716.1	FUSC family protein	-
QAO33_RS12920 (QAO33_12915)	-	2648387..2648800 (-)	414	WP_001670387.1	hypothetical protein	-
QAO33_RS12925 (QAO33_12920)	-	2648829..2648939 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=819129 QAO33_RS12895 WP_001017131.1 2643322..2644365(-) (vraS) [Staphylococcus aureus strain GE-MSSA33]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=819129 QAO33_RS12895 WP_001017131.1 2643322..2644365(-) (vraS) [Staphylococcus aureus strain GE-MSSA33]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAGTTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTGGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1