Detailed information NTG0818998

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: QAY61_RS10135
• Genome accession: NZ_CP123115
• Coordinates: 2066749..2067792 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain IT-MRSA43
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2061749..2072792

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QAY61_RS10105 (QAY61_10080)	-	2062170..2063426 (-)	1257	WP_075583716.1	aminopeptidase	-
QAY61_RS10110 (QAY61_10085)	-	2063429..2063629 (-)	201	WP_000180460.1	DUF1128 family protein	-
QAY61_RS10115 (QAY61_10090)	-	2063776..2064240 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
QAY61_RS10120 (QAY61_10095)	-	2064247..2064522 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
QAY61_RS10125 (QAY61_10100)	-	2064800..2066017 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
QAY61_RS10130 (QAY61_10105)	vraR	2066130..2066759 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
QAY61_RS10135 (QAY61_10110)	vraS	2066749..2067792 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
QAY61_RS10140 (QAY61_10115)	liaF	2067789..2068490 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
QAY61_RS10145 (QAY61_10120)	-	2068505..2068891 (-)	387	WP_001110179.1	hypothetical protein	-
QAY61_RS10150 (QAY61_10125)	map	2069108..2069866 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
QAY61_RS10155 (QAY61_10130)	-	2070395..2071381 (+)	987	WP_000999713.1	FUSC family protein	-
QAY61_RS10160 (QAY61_10135)	-	2071812..2072225 (-)	414	WP_001670387.1	hypothetical protein	-
QAY61_RS10165 (QAY61_10140)	-	2072254..2072364 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=818998 QAY61_RS10135 WP_001017131.1 2066749..2067792(-) (vraS) [Staphylococcus aureus strain IT-MRSA43]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=818998 QAY61_RS10135 WP_001017131.1 2066749..2067792(-) (vraS) [Staphylococcus aureus strain IT-MRSA43]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1