Detailed information NTG0818836

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: QAO52_RS00505
• Genome accession: NZ_CP123108
• Coordinates: 91583..92626 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain IT-MSSA49
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 86583..97626

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QAO52_RS00475 (QAO52_00470)	-	87011..87121 (+)	111	WP_057488483.1	hypothetical protein	-
QAO52_RS00480 (QAO52_00475)	-	87150..87563 (+)	414	WP_001549145.1	hypothetical protein	-
QAO52_RS00485 (QAO52_00480)	-	87936..88922 (-)	987	WP_000999713.1	FUSC family protein	-
QAO52_RS00490 (QAO52_00485)	map	89509..90267 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
QAO52_RS00495 (QAO52_00490)	-	90484..90870 (+)	387	WP_001110179.1	hypothetical protein	-
QAO52_RS00500 (QAO52_00495)	liaF	90885..91586 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
QAO52_RS00505 (QAO52_00500)	vraS	91583..92626 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
QAO52_RS00510 (QAO52_00505)	vraR	92616..93245 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
QAO52_RS00515 (QAO52_00510)	-	93361..94578 (-)	1218	WP_000037069.1	YihY/virulence factor BrkB family protein	-
QAO52_RS00520 (QAO52_00515)	-	94856..95131 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
QAO52_RS00525 (QAO52_00520)	-	95138..95602 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
QAO52_RS00530 (QAO52_00525)	-	95749..95949 (+)	201	WP_000180461.1	DUF1128 family protein	-
QAO52_RS00535 (QAO52_00530)	-	95952..97208 (+)	1257	WP_001795438.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=818836 QAO52_RS00505 WP_001017131.1 91583..92626(+) (vraS) [Staphylococcus aureus strain IT-MSSA49]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=818836 QAO52_RS00505 WP_001017131.1 91583..92626(+) (vraS) [Staphylococcus aureus strain IT-MSSA49]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1