Detailed information NTG0818625

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: QAY62_RS00495
• Genome accession: NZ_CP123097
• Coordinates: 89724..90767 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain MRSA-ATCC43300
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 84724..95767

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QAY62_RS00465 (QAY62_00460)	-	85186..85296 (+)	111	WP_001790257.1	hypothetical protein	-
QAY62_RS00470 (QAY62_00465)	-	85325..85780 (+)	456	WP_102695924.1	hypothetical protein	-
QAY62_RS00475 (QAY62_00470)	-	85908..86894 (-)	987	WP_001014423.1	FUSC family protein	-
QAY62_RS00480 (QAY62_00475)	map	87650..88408 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
QAY62_RS00485 (QAY62_00480)	-	88625..89011 (+)	387	WP_001110178.1	hypothetical protein	-
QAY62_RS00490 (QAY62_00485)	liaF	89026..89727 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
QAY62_RS00495 (QAY62_00490)	vraS	89724..90767 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
QAY62_RS00500 (QAY62_00495)	vraR	90757..91386 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
QAY62_RS00505 (QAY62_00500)	-	91499..92716 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
QAY62_RS00510 (QAY62_00505)	-	92994..93269 (-)	276	WP_070002542.1	YtxH domain-containing protein	-
QAY62_RS00515 (QAY62_00510)	-	93276..93740 (-)	465	WP_061843272.1	low molecular weight protein-tyrosine-phosphatase	-
QAY62_RS00520 (QAY62_00515)	-	93887..94087 (+)	201	WP_000180460.1	DUF1128 family protein	-
QAY62_RS00525 (QAY62_00520)	-	94090..95346 (+)	1257	WP_001793983.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=818625 QAY62_RS00495 WP_001017131.1 89724..90767(+) (vraS) [Staphylococcus aureus strain MRSA-ATCC43300]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=818625 QAY62_RS00495 WP_001017131.1 89724..90767(+) (vraS) [Staphylococcus aureus strain MRSA-ATCC43300]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1