Detailed information NTG0818539

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: QAY74_RS00500
• Genome accession: NZ_CP123093
• Coordinates: 90297..91340 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain MRSA-EDCC5443
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 85297..96340

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QAY74_RS00470 (QAY74_00460)	-	85725..85835 (+)	111	WP_001790257.1	hypothetical protein	-
QAY74_RS00475 (QAY74_00465)	-	85864..86277 (+)	414	WP_001670387.1	hypothetical protein	-
QAY74_RS00480 (QAY74_00470)	-	86708..87694 (-)	987	WP_000999713.1	FUSC family protein	-
QAY74_RS00485 (QAY74_00475)	map	88223..88981 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
QAY74_RS00490 (QAY74_00480)	-	89198..89584 (+)	387	WP_001110179.1	hypothetical protein	-
QAY74_RS00495 (QAY74_00485)	liaF	89599..90300 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
QAY74_RS00500 (QAY74_00490)	vraS	90297..91340 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
QAY74_RS00505 (QAY74_00495)	vraR	91330..91959 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
QAY74_RS00510 (QAY74_00500)	-	92072..93289 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
QAY74_RS00515 (QAY74_00505)	-	93567..93842 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
QAY74_RS00520 (QAY74_00510)	-	93849..94313 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
QAY74_RS00525 (QAY74_00515)	-	94460..94660 (+)	201	WP_000180460.1	DUF1128 family protein	-
QAY74_RS00530 (QAY74_00520)	-	94663..95919 (+)	1257	WP_075583716.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=818539 QAY74_RS00500 WP_001017131.1 90297..91340(+) (vraS) [Staphylococcus aureus strain MRSA-EDCC5443]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=818539 QAY74_RS00500 WP_001017131.1 90297..91340(+) (vraS) [Staphylococcus aureus strain MRSA-EDCC5443]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1