Detailed information
Bioinformatically predicted
Overview
| Name | ccrB | Type | Machinery gene |
| Locus tag | QAY69_RS10260 | Genome accession | NZ_CP123091 |
| Coordinates | 2031795..2033423 (-) | Length | 542 a.a. |
| NCBI ID | WP_001186602.1 | Uniprot ID | Q9XB94 |
| Organism | Staphylococcus aureus strain MRSA-Mu50 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 2026574..2070299 | 2031795..2033423 | within | 0 |
| SCCmec | 2013429..2034794 | 2031795..2033423 | within | 0 |
Gene organization within MGE regions
Location: 2013429..2070299
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| QAY69_RS10155 (QAY69_10155) | mecA | 2013429..2015438 (-) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| QAY69_RS10160 (QAY69_10160) | mecR1 | 2015535..2017292 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| QAY69_RS10165 (QAY69_10165) | mecI | 2017292..2017663 (+) | 372 | WP_000369211.1 | mecA-type methicillin resistance repressor MecI | - |
| QAY69_RS10170 (QAY69_10170) | psm-mec | 2017748..2017816 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| QAY69_RS10175 (QAY69_10175) | - | 2018171..2019280 (+) | 1110 | WP_025174171.1 | ROK family transcriptional regulator | - |
| QAY69_RS10180 (QAY69_10180) | cstB | 2019394..2020728 (-) | 1335 | Protein_1975 | persulfide dioxygenase-sulfurtransferase CstB | - |
| QAY69_RS10185 (QAY69_10185) | - | 2020761..2021825 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| QAY69_RS10190 (QAY69_10190) | cstR | 2021961..2022221 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| QAY69_RS10195 (QAY69_10195) | - | 2022221..2022859 (+) | 639 | Protein_1978 | sulfite exporter TauE/SafE family protein | - |
| QAY69_RS10200 | - | 2022913..2022972 (-) | 60 | Protein_1979 | DNA repair protein RadC | - |
| QAY69_RS10205 (QAY69_10200) | - | 2023204..2023866 (-) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| QAY69_RS10210 | - | 2024258..2024317 (+) | 60 | WP_010959190.1 | erythromycin resistance leader peptide | - |
| QAY69_RS10215 (QAY69_10205) | erm(A) | 2024400..2025131 (+) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| QAY69_RS10220 (QAY69_10210) | - | 2025257..2026039 (-) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| QAY69_RS10225 (QAY69_10215) | - | 2026190..2026567 (-) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| QAY69_RS10230 (QAY69_10220) | - | 2026574..2028466 (-) | 1893 | WP_001557544.1 | site-specific integrase | - |
| QAY69_RS10235 (QAY69_10225) | - | 2028463..2029548 (-) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| QAY69_RS10240 (QAY69_10230) | - | 2029667..2029984 (-) | 318 | WP_000659050.1 | JAB domain-containing protein | - |
| QAY69_RS10245 (QAY69_10235) | - | 2030005..2030511 (-) | 507 | WP_001092169.1 | DUF1643 domain-containing protein | - |
| QAY69_RS10250 (QAY69_10240) | - | 2030529..2030840 (-) | 312 | WP_000700853.1 | DUF960 family protein | - |
| QAY69_RS10255 (QAY69_10245) | - | 2030927..2031277 (-) | 351 | WP_000859153.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| QAY69_RS10260 (QAY69_10250) | ccrB | 2031795..2033423 (-) | 1629 | WP_001186602.1 | cassette chromosome recombinase CcrB | Machinery gene |
| QAY69_RS10265 (QAY69_10255) | ccrA | 2033445..2034794 (-) | 1350 | WP_000815646.1 | cassette chromosome recombinase CcrA | Machinery gene |
| QAY69_RS10270 (QAY69_10260) | cch1 | 2035028..2036821 (-) | 1794 | WP_000195100.1 | cassette chromosome replicative helicase | - |
| QAY69_RS10275 (QAY69_10265) | ssb | 2036821..2037117 (-) | 297 | WP_000273824.1 | cassette chromosome ssDNA-binding protein | - |
| QAY69_RS10280 (QAY69_10270) | - | 2037310..2038356 (-) | 1047 | WP_001060127.1 | hypothetical protein | - |
| QAY69_RS10285 (QAY69_10275) | - | 2038607..2039748 (-) | 1142 | Protein_1996 | IS3-like element ISSau4 family transposase | - |
| QAY69_RS10290 (QAY69_10280) | - | 2040259..2041194 (-) | 936 | Protein_1997 | YfcC family protein | - |
| QAY69_RS10295 (QAY69_10285) | - | 2041907..2042602 (-) | 696 | WP_000858967.1 | response regulator transcription factor | - |
| QAY69_RS10300 (QAY69_10290) | - | 2042577..2045210 (-) | 2634 | WP_010922810.1 | sensor histidine kinase | - |
| QAY69_RS10305 (QAY69_10295) | kdpF | 2045413..2045493 (+) | 81 | WP_000631574.1 | K(+)-transporting ATPase subunit F | - |
| QAY69_RS10310 (QAY69_10300) | kdpA | 2045514..2047190 (+) | 1677 | WP_000029430.1 | potassium-transporting ATPase subunit KdpA | - |
| QAY69_RS10315 (QAY69_10305) | - | 2047209..2049230 (+) | 2022 | WP_000852430.1 | K(+)-transporting ATPase subunit B | - |
| QAY69_RS10320 (QAY69_10310) | - | 2049246..2049803 (+) | 558 | WP_001193482.1 | K(+)-transporting ATPase subunit C | - |
| QAY69_RS10325 (QAY69_10315) | - | 2050348..2051217 (-) | 870 | WP_000626133.1 | hypothetical protein | - |
| QAY69_RS10330 (QAY69_10320) | - | 2051227..2052123 (-) | 897 | WP_000411461.1 | DUF927 domain-containing protein | - |
| QAY69_RS10335 (QAY69_10325) | - | 2053242..2053868 (-) | 627 | WP_001176969.1 | hypothetical protein | - |
| QAY69_RS10340 (QAY69_10330) | - | 2053983..2055491 (+) | 1509 | WP_001001347.1 | protein kinase domain-containing protein | - |
| QAY69_RS10345 (QAY69_10335) | - | 2055741..2055875 (-) | 135 | WP_001790628.1 | hypothetical protein | - |
| QAY69_RS10350 (QAY69_10340) | - | 2055839..2055931 (+) | 93 | WP_001790000.1 | hypothetical protein | - |
| QAY69_RS10355 (QAY69_10345) | - | 2056078..2057823 (+) | 1746 | WP_000700190.1 | DUF6119 family protein | - |
| QAY69_RS10360 (QAY69_10350) | - | 2057921..2058276 (-) | 356 | Protein_2011 | tRNA-dihydrouridine synthase | - |
| QAY69_RS10365 (QAY69_10355) | - | 2058581..2058669 (-) | 89 | Protein_2012 | hypothetical protein | - |
| QAY69_RS10370 (QAY69_10360) | - | 2058767..2059522 (-) | 756 | WP_000355845.1 | sulfite exporter TauE/SafE family protein | - |
| QAY69_RS10375 (QAY69_10365) | cstR | 2059522..2059782 (-) | 261 | WP_001105088.1 | persulfide-sensing transcriptional repressor CstR | - |
| QAY69_RS10380 (QAY69_10370) | cstA | 2059919..2060983 (+) | 1065 | WP_000816124.1 | persulfide response sulfurtransferase CstA | - |
| QAY69_RS10385 (QAY69_10375) | cstB | 2061014..2062348 (+) | 1335 | WP_000465472.1 | persulfide dioxygenase-sulfurtransferase CstB | - |
| QAY69_RS10390 (QAY69_10380) | sqr | 2062367..2063560 (+) | 1194 | WP_001033018.1 | type II sulfide:quinone oxidoreductase Sqr | - |
| QAY69_RS10395 | - | 2063827..2064041 (-) | 215 | Protein_2018 | universal stress protein | - |
| QAY69_RS10400 (QAY69_10385) | - | 2064227..2065213 (-) | 987 | WP_000662022.1 | tRNA dihydrouridine synthase | - |
| QAY69_RS10405 (QAY69_10390) | - | 2065522..2065725 (+) | 204 | WP_000389759.1 | DUF6007 family protein | - |
| QAY69_RS10410 (QAY69_10395) | - | 2065774..2066070 (+) | 297 | WP_000201644.1 | TfoX/Sxy family protein | - |
| QAY69_RS10415 (QAY69_10400) | - | 2066278..2066880 (+) | 603 | WP_000908956.1 | hypothetical protein | - |
| QAY69_RS10420 (QAY69_10405) | - | 2067147..2070299 (+) | 3153 | WP_000080564.1 | DEAD/DEAH box helicase | - |
Sequence
Protein
Download Length: 542 a.a. Molecular weight: 62664.84 Da Isoelectric Point: 9.8600
>NTDB_id=818530 QAY69_RS10260 WP_001186602.1 2031795..2033423(-) (ccrB) [Staphylococcus aureus strain MRSA-Mu50]
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRILKDAKEGYIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPNSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPVIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEDYVMKQILEIVKSDKVIQRVVTHVNQENQVDGAALHHDIAYKQQQYD
EVQIKLNNLIKTIEDNPDLTSVIRPSIQKYEKQLNDITNQINQLKNQQNEDKPLFDAKEISKLLQHIFHDIKHIEKSRLK
ALYLSVIDRIDIKKDGNHKKQFYVTLKLNNEIIKQLFNNKQLDEVHLSTSSLFLPQTLYLTI
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRILKDAKEGYIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPNSKHELMINQHEANIVKYIFESYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPVIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEDYVMKQILEIVKSDKVIQRVVTHVNQENQVDGAALHHDIAYKQQQYD
EVQIKLNNLIKTIEDNPDLTSVIRPSIQKYEKQLNDITNQINQLKNQQNEDKPLFDAKEISKLLQHIFHDIKHIEKSRLK
ALYLSVIDRIDIKKDGNHKKQFYVTLKLNNEIIKQLFNNKQLDEVHLSTSSLFLPQTLYLTI
Nucleotide
Download Length: 1629 bp
>NTDB_id=818530 QAY69_RS10260 WP_001186602.1 2031795..2033423(-) (ccrB) [Staphylococcus aureus strain MRSA-Mu50]
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTATCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGACGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAAGTTAAAGATATATACGCTGACCGTGGTA
TTTCAGGTAAATCTATGAATCGACCTGAGCTCCAACGTATATTGAAGGATGCGAAAGAAGGCTATATCGACTGTGTTATG
GTCTACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTCAGTTTATCAGAGCGTATGGAAGTCAATACTTCATCGGGTAAGCTCATGTTACAAATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAATGTATTTATGGGTCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCTAATAGTAAACATGAACTGATGATTAATCAACATGAAGCTAATATTGTGAAATA
TATATTCGAGTCCTATGCCAAAGGCCATGGCTATCGTAAAATAGCCAATGCATTAAATCACAAAGGCTATGTCACTAAAA
AGGGTAAACCTTTTAGTATTAGTTCTATCACATATATATTAGCTAACCCATTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTTAATGATAAACCAGTGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAAAAACAAGTCAGTCAAAAACCCCAAGTCCATGGCAAAGGAACGA
ATCTGCTTACAGGCATTATTCACTGTCCCCAATGTGGCGCACCTATGGCAGCAAGCAATACCACGAATACACTTAAAGAC
GGGACTAAGAAACGTATTCGTTACTATTCATGTAGTAATTTTCGGAACAAGGGTTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTGATGTGATTGAAGATTATGTGATGAAGCAAATACTTGAAATAGTCAAAAGTGATAAAGTCATTCAACGCGTAG
TAACACACGTCAATCAAGAAAATCAAGTTGATGGCGCTGCACTTCATCACGATATTGCTTATAAGCAACAACAATATGAT
GAAGTACAAATCAAACTAAATAACTTGATTAAAACCATCGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGCAACTCAATGACATTACGAATCAAATCAACCAACTCAAAAATCAACAAAATGAAGATAAGCCTT
TATTTGATGCCAAAGAAATCAGTAAACTATTACAACACATCTTTCATGATATTAAGCACATAGAAAAATCTCGACTCAAA
GCATTGTATCTATCAGTGATTGATCGCATTGATATTAAAAAAGATGGTAATCATAAAAAACAATTCTATGTCACACTCAA
ACTTAATAACGAAATCATAAAACAACTTTTCAATAATAAACAACTCGACGAAGTGCATCTCAGCACTTCGTCTTTGTTTT
TGCCCCAAACACTATATCTTACTATTTAG
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTATCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGACGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAAGTTAAAGATATATACGCTGACCGTGGTA
TTTCAGGTAAATCTATGAATCGACCTGAGCTCCAACGTATATTGAAGGATGCGAAAGAAGGCTATATCGACTGTGTTATG
GTCTACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTCAGTTTATCAGAGCGTATGGAAGTCAATACTTCATCGGGTAAGCTCATGTTACAAATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAATGTATTTATGGGTCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGCAAT
TTGCCGCTGGGCTATGACAAAATACCTAATAGTAAACATGAACTGATGATTAATCAACATGAAGCTAATATTGTGAAATA
TATATTCGAGTCCTATGCCAAAGGCCATGGCTATCGTAAAATAGCCAATGCATTAAATCACAAAGGCTATGTCACTAAAA
AGGGTAAACCTTTTAGTATTAGTTCTATCACATATATATTAGCTAACCCATTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTTAATGATAAACCAGTGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAAAAACAAGTCAGTCAAAAACCCCAAGTCCATGGCAAAGGAACGA
ATCTGCTTACAGGCATTATTCACTGTCCCCAATGTGGCGCACCTATGGCAGCAAGCAATACCACGAATACACTTAAAGAC
GGGACTAAGAAACGTATTCGTTACTATTCATGTAGTAATTTTCGGAACAAGGGTTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTGATGTGATTGAAGATTATGTGATGAAGCAAATACTTGAAATAGTCAAAAGTGATAAAGTCATTCAACGCGTAG
TAACACACGTCAATCAAGAAAATCAAGTTGATGGCGCTGCACTTCATCACGATATTGCTTATAAGCAACAACAATATGAT
GAAGTACAAATCAAACTAAATAACTTGATTAAAACCATCGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGCAACTCAATGACATTACGAATCAAATCAACCAACTCAAAAATCAACAAAATGAAGATAAGCCTT
TATTTGATGCCAAAGAAATCAGTAAACTATTACAACACATCTTTCATGATATTAAGCACATAGAAAAATCTCGACTCAAA
GCATTGTATCTATCAGTGATTGATCGCATTGATATTAAAAAAGATGGTAATCATAAAAAACAATTCTATGTCACACTCAA
ACTTAATAACGAAATCATAAAACAACTTTTCAATAATAAACAACTCGACGAAGTGCATCTCAGCACTTCGTCTTTGTTTT
TGCCCCAAACACTATATCTTACTATTTAG
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrB | Staphylococcus aureus N315 |
100 |
100 |
1 |