Detailed information NTG0818204

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: QAO35_RS05870
• Genome accession: NZ_CP123074
• Coordinates: 1185100..1186143 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain SW-MRSA61
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1180100..1191143

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QAO35_RS05840 (QAO35_05855)	-	1180526..1180636 (+)	111	WP_001790257.1	hypothetical protein	-
QAO35_RS05845 (QAO35_05860)	-	1180665..1181078 (+)	414	WP_001557448.1	hypothetical protein	-
QAO35_RS05850 (QAO35_05865)	-	1181509..1182495 (-)	987	WP_000999717.1	FUSC family protein	-
QAO35_RS05855 (QAO35_05870)	map	1183026..1183784 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
QAO35_RS05860 (QAO35_05875)	-	1184001..1184387 (+)	387	WP_001110179.1	hypothetical protein	-
QAO35_RS05865 (QAO35_05880)	liaF	1184402..1185103 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
QAO35_RS05870 (QAO35_05885)	vraS	1185100..1186143 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
QAO35_RS05875 (QAO35_05890)	vraR	1186133..1186762 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
QAO35_RS05880 (QAO35_05895)	-	1186875..1188092 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
QAO35_RS05885 (QAO35_05900)	-	1188370..1188645 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
QAO35_RS05890 (QAO35_05905)	-	1188652..1189116 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
QAO35_RS05895 (QAO35_05910)	-	1189263..1189463 (+)	201	WP_078066076.1	DUF1128 domain-containing protein	-
QAO35_RS05900 (QAO35_05915)	-	1189466..1190722 (+)	1257	WP_001795108.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=818204 QAO35_RS05870 WP_001017131.1 1185100..1186143(+) (vraS) [Staphylococcus aureus strain SW-MRSA61]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=818204 QAO35_RS05870 WP_001017131.1 1185100..1186143(+) (vraS) [Staphylococcus aureus strain SW-MRSA61]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1