Detailed information NTG0817669

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: LLUL033_RS03300
• Genome accession: NZ_CP122980
• Coordinates: 624697..627147 (+)
• Length: 816 a.a.
• NCBI ID: WP_259692034.1
• Uniprot ID: -
• Organism: Lactococcus cremoris strain UL033
• Function: degradation of ComX (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Prophage	603303..637983	624697..627147	within	0
IScluster/Tn	621428..624021	624697..627147	flank	676

Gene organization within MGE regions

Location: 603303..637983

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
LLUL033_RS03175 (LLUL033_03165)	-	603303..603971 (+)	669	WP_011834609.1	hypothetical protein	-
LLUL033_RS03180 (LLUL033_03170)	-	604136..605038 (+)	903	WP_011675768.1	SPFH domain-containing protein	-
LLUL033_RS03190 (LLUL033_03180)	-	605287..606303 (-)	1017	WP_011834610.1	site-specific integrase	-
LLUL033_RS03195 (LLUL033_03185)	-	606525..607016 (-)	492	WP_011834611.1	hypothetical protein	-
LLUL033_RS03200 (LLUL033_03190)	-	607072..607277 (-)	206	Protein_602	hypothetical protein	-
LLUL033_RS03205	-	607292..607887 (-)	596	Protein_603	hypothetical protein	-
LLUL033_RS03210	-	607987..608076 (-)	90	Protein_604	phage repressor protein	-
LLUL033_RS03215 (LLUL033_03210)	-	608057..608233 (-)	177	WP_014734944.1	hypothetical protein	-
LLUL033_RS03220 (LLUL033_03215)	-	608527..610134 (+)	1608	WP_063284109.1	glycosyltransferase family 39 protein	-
LLUL033_RS03225 (LLUL033_03220)	-	610058..610990 (+)	933	WP_161769936.1	glycosyltransferase family 2 protein	-
LLUL033_RS03230 (LLUL033_03225)	-	611257..611748 (-)	492	WP_011834617.1	hypothetical protein	-
LLUL033_RS03235 (LLUL033_03230)	-	611761..612135 (-)	375	WP_011834618.1	PH domain-containing protein	-
LLUL033_RS03240 (LLUL033_03235)	-	612480..612827 (-)	348	WP_011834619.1	XRE family transcriptional regulator	-
LLUL033_RS03250 (LLUL033_03245)	rnz	613593..614516 (+)	924	WP_011834620.1	ribonuclease Z	-
LLUL033_RS03255 (LLUL033_03250)	-	614509..615210 (+)	702	WP_014734945.1	SDR family oxidoreductase	-
LLUL033_RS03260 (LLUL033_03255)	recJ	615383..617611 (+)	2229	WP_014734946.1	single-stranded-DNA-specific exonuclease RecJ	-
LLUL033_RS03265 (LLUL033_03260)	-	617735..618247 (+)	513	WP_011834623.1	adenine phosphoribosyltransferase	-
LLUL033_RS03270 (LLUL033_03265)	rpoE	618463..619029 (+)	567	WP_011834624.1	DNA-directed RNA polymerase subunit delta	-
LLUL033_RS03275 (LLUL033_03270)	mltG	619165..620805 (+)	1641	WP_041931175.1	endolytic transglycosylase MltG	-
LLUL033_RS03280 (LLUL033_03275)	greA	620866..621336 (+)	471	WP_011834626.1	transcription elongation factor GreA	-
LLUL033_RS03285 (LLUL033_03280)	-	621428..622802 (+)	1375	Protein_618	IS3-like element ISLla3 family transposase	-
LLUL033_RS03290 (LLUL033_03285)	-	622874..624021 (+)	1148	WP_192824012.1	IS3 family transposase	-
LLUL033_RS03295 (LLUL033_03290)	-	624252..624707 (+)	456	WP_011834627.1	CtsR family transcriptional regulator	-
LLUL033_RS03300 (LLUL033_03295)	clpC	624697..627147 (+)	2451	WP_259692034.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
LLUL033_RS03305 (LLUL033_03300)	hpf	627282..627839 (+)	558	WP_011834629.1	ribosome hibernation-promoting factor, HPF/YfiA family	-
LLUL033_RS03310 (LLUL033_03305)	eno	628027..629328 (+)	1302	WP_010905473.1	surface-displayed alpha-enolase	-
LLUL033_RS03315 (LLUL033_03310)	-	629417..630352 (+)	936	WP_332370554.1	tyrosine-type recombinase/integrase	-
LLUL033_RS03320 (LLUL033_03315)	-	630479..630922 (+)	444	WP_260368644.1	hypothetical protein	-
LLUL033_RS03325 (LLUL033_03320)	-	630989..631276 (+)	288	WP_260368643.1	hypothetical protein	-
LLUL033_RS03330 (LLUL033_03325)	istB	631908..632666 (-)	759	WP_003331414.1	IS21-like element IS712 family helper ATPase IstB	-
LLUL033_RS03335 (LLUL033_03330)	istA	632678..633901 (-)	1224	WP_124137938.1	IS21-like element IS712 family transposase	-
LLUL033_RS03345	-	635533..635607 (+)	75	WP_375378903.1	hypothetical protein	-
LLUL033_RS03350 (LLUL033_03340)	-	635625..635948 (+)	324	WP_063282844.1	hypothetical protein	-
LLUL033_RS03355 (LLUL033_03345)	-	636045..636779 (+)	735	WP_259692858.1	putative phage abortive infection protein	-
LLUL033_RS03360 (LLUL033_03350)	-	637104..637208 (+)	105	Protein_633	hypothetical protein	-
LLUL033_RS03365 (LLUL033_03355)	-	637312..637983 (-)	672	WP_011834634.1	ABC transporter ATP-binding protein	-

Sequence

Protein

• Length: 816 a.a.
• Molecular weight: 90363.72 Da
• Isoelectric Point: 6.6284

>NTDB_id=817669 LLUL033_RS03300 WP_259692034.1 624697..627147(+) (clpC) [Lactococcus cremoris strain UL033]
MKFENVKYTPTLDRIFEKAAEYAHQYQYGTIESAHLLAAMATTSGSIAYSILAGMNVDSSDLLIDLEDLSSHVKVKRSEL
RFSPRAEEVVTVASFLAVHNNAEAVGTEHLLYALLQVEDGFGLQLLKLQKINIVSLRKEIEKRTGLKVPENKKAVTPMSK
RKMAKGVAENSSTPTLDSVSSDLTEAARSGKLDPMIGREAEVDRLIHILSRRTKNNPVLVGEPGVGKSAIIEGLAQRIVN
GQVPIGLMNSRIMALNMATVVAGTKFRGEFEDRLTAIVEEVSADPDVIIFIDELHTIIGAGGGMDSVNDAANILKPALAR
GDFQMVGATTYHEYQKYIEKDEALERRLARINVDEPSPDEAIAILQGLREKFEDYHQVKFTDQAIKSAVTLSVRYMTSRK
LPDKAIDLLDEAAAAVKISVKNQETKRLELEKDLVKAQEELAEAVIKLDVKASRIKEKAVEKNSDKIYKFSIKEEKRQEV
TDQAVIAVASTLTGVPITQMTKSESDRLINLEKELHKRVVGQEEAISAVSRAIRRARSGVADSRRPMGSFMFLGPTGVGK
TELAKALADSVFGSEDNMIRVDMSEFMEKHSTSRLIGAPPGYVGYDEGGQLTERVRNKPYSVVLLDEVEKAHLDVFNIML
QILDDGFVTDTKGRKVDFRNTIIIMTSNLGATALRDDKTVGFGAKNITADYSAMQSRILEELKRHYRPEFLNRIDENIVF
HSLESQEIEQIVKIMSKSLIKRLAEQDIHVKLTPSAIKLIAEVGFDPEYGARPLRKALQKEVEDLLSEQLLSGEIKAGNH
ISIGASNKKIKIAQIV

Nucleotide

• Length: 2451 bp

>NTDB_id=817669 LLUL033_RS03300 WP_259692034.1 624697..627147(+) (clpC) [Lactococcus cremoris strain UL033]
ATGAAATTTGAAAATGTAAAATATACACCAACACTGGACCGAATTTTCGAGAAAGCAGCAGAATATGCCCACCAATATCA
ATACGGTACGATTGAAAGTGCTCATTTATTGGCAGCAATGGCTACTACTTCAGGCTCAATTGCTTACAGTATTCTTGCTG
GAATGAATGTTGATTCTTCAGACTTACTGATTGATTTGGAAGATTTATCTAGCCATGTCAAAGTGAAACGTTCTGAATTA
CGTTTCTCTCCTCGCGCAGAAGAAGTGGTTACTGTAGCTAGCTTTTTGGCAGTTCATAATAATGCAGAAGCAGTAGGAAC
AGAGCATTTGCTTTATGCATTACTTCAAGTCGAAGATGGTTTTGGTCTTCAACTTTTGAAGTTACAAAAAATCAACATTG
TTTCTTTGCGAAAAGAAATTGAAAAAAGAACAGGACTTAAAGTTCCAGAAAACAAAAAAGCTGTAACACCAATGTCCAAA
CGTAAGATGGCAAAAGGGGTAGCAGAGAATTCAAGTACACCAACTTTGGATTCAGTTTCTTCAGATTTAACTGAAGCTGC
TCGTTCAGGAAAGCTTGACCCAATGATTGGTCGGGAAGCAGAAGTTGACCGTTTGATTCATATTCTTAGTCGTAGAACAA
AAAATAACCCTGTTTTAGTTGGTGAACCTGGTGTTGGTAAATCAGCAATAATCGAGGGATTGGCTCAAAGAATTGTCAAC
GGCCAAGTACCTATCGGTTTGATGAATAGCCGGATTATGGCTCTAAATATGGCAACTGTTGTTGCTGGTACAAAATTTAG
AGGTGAATTTGAAGACCGCTTGACAGCAATTGTTGAAGAAGTAAGTGCTGACCCAGATGTCATCATTTTCATTGATGAAT
TGCATACAATTATTGGTGCTGGCGGGGGCATGGACTCGGTCAATGATGCAGCAAATATTTTAAAACCAGCCCTTGCACGT
GGTGACTTTCAAATGGTTGGGGCAACGACTTATCATGAATACCAAAAATACATTGAAAAAGATGAAGCATTAGAACGTCG
TTTGGCAAGAATCAATGTTGATGAGCCAAGTCCAGATGAAGCCATTGCTATCTTACAAGGGTTACGTGAGAAATTTGAAG
ATTATCATCAAGTAAAATTTACTGACCAAGCGATTAAAAGCGCAGTGACACTTAGTGTTCGGTACATGACCAGTCGCAAA
TTGCCTGATAAAGCCATTGACTTGCTCGATGAAGCAGCGGCAGCAGTTAAAATTTCTGTTAAAAACCAAGAAACAAAACG
TCTTGAATTAGAGAAAGACTTAGTTAAAGCTCAAGAAGAACTAGCGGAAGCTGTCATTAAACTTGATGTTAAAGCCTCTC
GCATCAAAGAAAAAGCTGTTGAAAAAAATTCTGACAAGATTTATAAATTCTCAATAAAAGAGGAAAAACGTCAAGAAGTT
ACTGACCAAGCTGTTATTGCTGTTGCCTCAACGCTGACAGGTGTTCCAATTACTCAAATGACTAAATCTGAAAGCGACCG
TTTGATTAATCTTGAAAAAGAATTGCACAAACGGGTCGTTGGTCAAGAAGAAGCAATTTCTGCGGTTTCAAGAGCCATTC
GTCGGGCACGTTCTGGTGTGGCTGATAGTCGCCGTCCAATGGGTTCATTTATGTTTCTAGGACCAACTGGTGTTGGGAAA
ACTGAGTTAGCTAAGGCCTTGGCCGATAGTGTTTTTGGTAGCGAAGACAACATGATTCGAGTGGACATGAGTGAATTCAT
GGAAAAACATTCAACTTCACGCTTGATTGGGGCCCCTCCAGGATATGTTGGTTATGATGAAGGTGGTCAATTGACTGAAC
GCGTTCGTAATAAACCCTATTCTGTGGTTCTTTTAGATGAAGTTGAGAAAGCTCATCTTGACGTTTTCAATATCATGTTG
CAAATTCTAGATGATGGATTTGTGACAGATACAAAGGGCCGCAAAGTTGATTTTAGAAACACAATTATTATCATGACTTC
AAACTTGGGTGCAACGGCTCTTCGTGATGATAAAACAGTTGGTTTTGGTGCAAAAAATATCACGGCTGACTACTCAGCTA
TGCAATCAAGAATTTTGGAAGAACTTAAACGTCATTATCGTCCAGAGTTTCTCAATCGTATTGATGAAAACATTGTTTTC
CATTCATTGGAAAGTCAAGAAATTGAACAAATTGTTAAGATTATGAGCAAATCTTTGATTAAACGTTTGGCGGAACAAGA
TATTCATGTGAAACTTACGCCATCAGCAATAAAACTAATCGCTGAAGTAGGATTTGACCCAGAATATGGGGCACGTCCAT
TGCGTAAAGCACTCCAAAAAGAAGTTGAAGATCTTTTAAGTGAACAATTGCTCTCGGGTGAGATTAAAGCAGGAAATCAT
ATTTCCATTGGTGCTTCTAATAAAAAAATTAAAATCGCTCAAATTGTTTGA

Domains

Predicted by InterproScan.

• AAA lid domain (AAA_lid_9) (357-449)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (723-802)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (96-144)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (19-69)

• AAA domain (Cdc48 subfamily) (AAA_2) (545-716)

• ATPase family associated with various cellular activities (AAA) (AAA) (218-334)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	95.833	100	0.958
clpC	Streptococcus thermophilus LMD-9	50.903	100	0.518
clpC	Streptococcus thermophilus LMG 18311	50.782	100	0.517
clpC	Streptococcus mutans UA159	48.918	100	0.499
clpC	Streptococcus pneumoniae Rx1	49.153	100	0.498
clpC	Streptococcus pneumoniae D39	49.153	100	0.498
clpC	Streptococcus pneumoniae TIGR4	49.031	100	0.496
clpC	Bacillus subtilis subsp. subtilis str. 168	49.876	98.529	0.491
clpE	Streptococcus mutans UA159	46.769	79.657	0.373
clpC	Lactococcus lactis subsp. cremoris KW2	46.248	80.025	0.37
clpE	Streptococcus pneumoniae TIGR4	46.89	76.838	0.36
clpE	Streptococcus pneumoniae Rx1	46.89	76.838	0.36
clpE	Streptococcus pneumoniae D39	46.89	76.838	0.36
clpE	Streptococcus pneumoniae R6	46.89	76.838	0.36