Detailed information NTG0815940

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: QAY59_RS06870
• Genome accession: NZ_CP122487
• Coordinates: 1373959..1375002 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain IT-MRSA45
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1368959..1380002

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QAY59_RS06840 (QAY59_06830)	-	1369387..1370643 (-)	1257	WP_001793428.1	aminopeptidase	-
QAY59_RS06845 (QAY59_06835)	-	1370646..1370846 (-)	201	WP_000180460.1	DUF1128 family protein	-
QAY59_RS06850 (QAY59_06840)	-	1370993..1371457 (+)	465	WP_103146332.1	low molecular weight protein-tyrosine-phosphatase	-
QAY59_RS06855 (QAY59_06845)	-	1371464..1371739 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
QAY59_RS06860 (QAY59_06850)	-	1372017..1373228 (+)	1212	WP_000037091.1	YihY/virulence factor BrkB family protein	-
QAY59_RS06865 (QAY59_06855)	vraR	1373340..1373969 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
QAY59_RS06870 (QAY59_06860)	vraS	1373959..1375002 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
QAY59_RS06875 (QAY59_06865)	liaF	1374999..1375700 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
QAY59_RS06880 (QAY59_06870)	-	1375715..1376101 (-)	387	WP_001110179.1	hypothetical protein	-
QAY59_RS06885 (QAY59_06875)	map	1376318..1377076 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
QAY59_RS06890 (QAY59_06880)	-	1377607..1378593 (+)	987	WP_000999713.1	FUSC family protein	-
QAY59_RS06895 (QAY59_06885)	-	1379083..1379496 (-)	414	WP_001837236.1	hypothetical protein	-
QAY59_RS06900 (QAY59_06890)	-	1379525..1379636 (-)	112	Protein_1334	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=815940 QAY59_RS06870 WP_001017131.1 1373959..1375002(-) (vraS) [Staphylococcus aureus strain IT-MRSA45]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=815940 QAY59_RS06870 WP_001017131.1 1373959..1375002(-) (vraS) [Staphylococcus aureus strain IT-MRSA45]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1