Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpE   Type   Regulator
Locus tag   QBE57_RS06390 Genome accession   NZ_CP121670
Coordinates   1301010..1303238 (+) Length   742 a.a.
NCBI ID   WP_011922698.1    Uniprot ID   D5AGE0
Organism   Streptococcus suis strain HBXY-SL     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1296010..1308238
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  QBE57_RS06365 - 1296294..1296587 (-) 294 WP_002938694.1 hypothetical protein -
  QBE57_RS06370 - 1298036..1298884 (-) 849 WP_011922050.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase -
  QBE57_RS06375 - 1299014..1299748 (-) 735 WP_002943067.1 amino acid ABC transporter ATP-binding protein -
  QBE57_RS06380 - 1299741..1300430 (-) 690 WP_002938702.1 amino acid ABC transporter permease -
  QBE57_RS06385 - 1300556..1300786 (-) 231 WP_002938704.1 DUF1797 family protein -
  QBE57_RS06390 clpE 1301010..1303238 (+) 2229 WP_011922698.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  QBE57_RS06395 - 1303424..1303885 (+) 462 WP_002938708.1 NUDIX hydrolase -
  QBE57_RS06400 - 1303940..1304248 (+) 309 WP_002938710.1 DUF1827 family protein -
  QBE57_RS06405 ileS 1304627..1307416 (-) 2790 WP_014636241.1 isoleucine--tRNA ligase -
  QBE57_RS06410 - 1307427..1307870 (-) 444 WP_012774999.1 GNAT family N-acetyltransferase -

Sequence

Protein


Download         Length: 742 a.a.        Molecular weight: 82607.98 Da        Isoelectric Point: 5.4248

>NTDB_id=813783 QBE57_RS06390 WP_011922698.1 1301010..1303238(+) (clpE) [Streptococcus suis strain HBXY-SL]
MLCKNCNINDATIHLYTNLNGKQQQVDLCHNCYQIMKTDPHNAILRGLGDLTNPNNMDPFSEFFNHLGGYPGNTPAGKNR
EQTPPTQAGGHNGRGGQTPPPQQPQQPNGLLEEFGINVTEIARRGDIDPVIGRDQEITRVIEILNRRTKNNPVLIGEPGV
GKTAVVEGLAQKIVDGDVPQKLRDKEVIRLDVVSLVQGTGIRGQFEERMQKLMEEIRNRREIILFIDEIHEIVGAGSAGD
GNMDAGNILKPALARGEMQLVGATTLNEYRIIEKDAALERRMQPVKVEEPSVEETITILKGIQNKYQDYHHVKYSDAAIE
AAAVLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFIDPKEIDQRLIDSENRKAQATRDEDYEKAAYFRDQIAKYKEMQK
ATISEEDIPLITEKEIEAIVEQKTNIPVGDLKEKEQSQLVSLASDLKAHVIGQDEAVDKIAKAIRRNRVGLGAPNRPIGS
FLFVGPTGVGKTELSKQLAIELFGSADSMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEKVRRNPYSLILLDEVE
KAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKVEASVGFGAAMEGRTQSVLGQLSNFFTPEFMNRFDG
IIEFQPLSKENLLEIVSLMLDDVNKRLSHNGISLHVTDKVKEKLVDLGYNPKMGARPLRRTIQDQIEDAITDFYLEHPAE
KDLRAVMSSKGTIQIKAQTKTK

Nucleotide


Download         Length: 2229 bp        

>NTDB_id=813783 QBE57_RS06390 WP_011922698.1 1301010..1303238(+) (clpE) [Streptococcus suis strain HBXY-SL]
ATGCTCTGCAAAAATTGTAATATCAACGACGCAACGATCCATCTCTACACCAACTTAAACGGTAAACAGCAGCAGGTAGA
CCTCTGTCACAACTGCTACCAAATCATGAAAACAGACCCTCATAATGCTATCCTACGTGGGTTGGGAGATTTAACAAATC
CTAACAATATGGATCCCTTTAGTGAATTTTTCAATCACCTAGGTGGCTATCCTGGCAATACCCCTGCTGGAAAAAATCGC
GAACAGACTCCTCCCACTCAAGCCGGTGGGCATAATGGACGTGGTGGACAGACCCCTCCTCCGCAACAACCCCAACAACC
AAATGGGCTCCTTGAAGAATTTGGTATCAACGTTACCGAAATTGCCCGTCGTGGGGATATTGATCCAGTAATCGGTCGCG
ATCAAGAAATTACCCGTGTCATCGAAATTCTCAACCGTCGTACAAAAAACAATCCTGTTCTTATCGGTGAGCCTGGGGTA
GGTAAAACAGCGGTTGTTGAAGGCTTGGCTCAAAAAATTGTCGATGGCGATGTCCCACAAAAATTACGAGACAAGGAAGT
CATTCGTCTGGATGTTGTCAGCCTCGTACAAGGAACAGGTATCCGTGGACAATTTGAAGAACGCATGCAAAAACTCATGG
AAGAAATCCGTAATCGTCGCGAAATCATTCTTTTTATTGACGAGATTCACGAAATTGTCGGTGCTGGCTCTGCAGGCGAT
GGTAACATGGATGCAGGCAATATCCTCAAACCAGCCCTCGCACGTGGTGAAATGCAACTAGTCGGTGCAACAACGCTCAA
CGAGTACCGTATTATCGAAAAAGATGCCGCCCTAGAACGCCGTATGCAACCTGTAAAAGTTGAAGAACCAAGTGTCGAAG
AAACCATTACCATCCTCAAAGGTATCCAAAATAAATACCAGGATTACCATCATGTTAAATACTCCGATGCTGCTATCGAA
GCTGCCGCAGTACTGTCCAATCGCTACATTCAAGACCGTTTCCTACCAGACAAGGCTATTGACCTTCTGGATGAAGCTGG
TTCAAAAATGAATTTGACCCTCAACTTTATTGATCCAAAGGAAATTGACCAACGCCTGATTGATTCCGAAAATCGTAAAG
CACAAGCTACACGGGATGAGGACTATGAAAAAGCAGCCTATTTCCGTGACCAAATTGCTAAGTACAAGGAGATGCAAAAG
GCAACTATCAGCGAAGAAGATATTCCACTCATTACTGAAAAAGAAATTGAAGCCATCGTTGAGCAAAAAACAAATATCCC
AGTTGGTGATTTAAAAGAAAAGGAACAGTCCCAGCTTGTGAGCCTCGCTAGTGACTTAAAAGCCCATGTTATCGGACAAG
ATGAAGCAGTTGACAAGATAGCTAAAGCCATCCGCCGTAATCGTGTCGGTCTCGGTGCTCCAAATCGTCCCATTGGTTCC
TTCCTCTTTGTCGGACCAACAGGTGTCGGTAAAACCGAATTGTCTAAGCAATTAGCTATCGAACTCTTCGGTTCGGCTGA
CAGCATGATCCGCTTCGACATGTCCGAATACATGGAAAAACACGCTGTCGCTAAACTCGTCGGAGCTCCTCCAGGCTATG
TAGGCTATGAGGAGGCTGGACAATTGACTGAAAAAGTTCGTCGTAATCCTTACTCACTCATCCTCCTTGACGAAGTTGAA
AAAGCCCACCCAGATGTCATGCACATGTTCCTTCAGGTCTTAGATGATGGGCGTCTGACAGATGGACAAGGTCGGACAGT
CAGCTTCAAAGATACCATTATCATCATGACATCAAATGCTGGTACTGGAAAAGTTGAAGCAAGTGTCGGTTTTGGTGCGG
CTATGGAAGGGCGGACTCAATCAGTCCTTGGCCAACTTAGCAATTTCTTCACACCTGAATTTATGAACCGATTTGACGGT
ATTATTGAGTTCCAACCACTGAGCAAGGAAAACCTACTTGAAATCGTCAGCCTCATGCTAGACGATGTAAACAAACGCCT
TTCTCACAATGGCATCAGCCTCCATGTAACAGATAAAGTTAAGGAGAAATTAGTGGACCTTGGCTACAATCCAAAGATGG
GAGCTCGTCCACTACGCAGAACCATCCAAGATCAGATTGAAGATGCTATCACCGACTTCTACTTAGAACATCCAGCAGAA
AAAGACCTACGTGCTGTCATGTCAAGTAAAGGTACAATTCAAATCAAGGCACAAACAAAGACAAAATAA

Domains

Predicted by InterproScan.

AAA lid domain (AAA_lid_9)

(291-388)

AAA domain (Cdc48 subfamily) (AAA_2)

(476-639)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(647-721)

ATPase family associated with various cellular activities (AAA) (AAA)

(153-272)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB D5AGE0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpE Streptococcus pneumoniae Rx1

81.963

100

0.833
  clpE Streptococcus pneumoniae D39

81.963

100

0.833
  clpE Streptococcus pneumoniae R6

81.963

100

0.833
  clpE Streptococcus pneumoniae TIGR4

81.963

100

0.833
  clpE Streptococcus mutans UA159

82.109

100

0.829
  clpC Lactococcus lactis subsp. cremoris KW2

77.517

97.709

0.757
  clpC Bacillus subtilis subsp. subtilis str. 168

52.154

87.601

0.457
  clpC Streptococcus thermophilus LMD-9

47.93

84.636

0.406
  clpC Streptococcus mutans UA159

48.237

84.097

0.406
  clpC Streptococcus thermophilus LMG 18311

47.611

84.636

0.403
  clpC Streptococcus pneumoniae Rx1

47.52

84.232

0.4
  clpC Streptococcus pneumoniae D39

47.52

84.232

0.4
  clpC Streptococcus pneumoniae TIGR4

47.52

84.232

0.4
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

46.338

84.636

0.392