Detailed information NTG0812650

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: QA605_RS05175
• Genome accession: NZ_CP121513
• Coordinates: 1098826..1099872 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain 20DL
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1093826..1104872

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QA605_RS05150	-	1094968..1095504 (+)	537	WP_001830372.1	hypothetical protein	-
QA605_RS05155	-	1095654..1096640 (-)	987	WP_002457091.1	aromatic acid exporter family protein	-
QA605_RS05160	map	1096814..1097569 (+)	756	WP_002457092.1	type I methionyl aminopeptidase	-
QA605_RS05165	-	1097727..1098113 (+)	387	WP_001830382.1	hypothetical protein	-
QA605_RS05170	liaF	1098128..1098829 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
QA605_RS05175	vraS	1098826..1099872 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
QA605_RS05180	vraR	1099862..1100491 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
QA605_RS05185	-	1100548..1101726 (-)	1179	WP_049376906.1	YihY/virulence factor BrkB family protein	-
QA605_RS05190	-	1102154..1102438 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
QA605_RS05195	-	1102446..1102910 (-)	465	WP_278275634.1	low molecular weight protein-tyrosine-phosphatase	-
QA605_RS05200	-	1103051..1103266 (+)	216	WP_070501292.1	DUF1128 domain-containing protein	-
QA605_RS05205	-	1103268..1104509 (+)	1242	WP_002503582.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=812650 QA605_RS05175 WP_001830374.1 1098826..1099872(+) (vraS) [Staphylococcus epidermidis strain 20DL]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=812650 QA605_RS05175 WP_001830374.1 1098826..1099872(+) (vraS) [Staphylococcus epidermidis strain 20DL]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGGCCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92