Detailed information NTG0812514

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: QA611_RS05215
• Genome accession: NZ_CP121497
• Coordinates: 1100541..1101587 (+)
• Length: 348 a.a.
• NCBI ID: WP_001830374.1
• Uniprot ID: A0A0N1EGU4
• Organism: Staphylococcus epidermidis strain 24FSE04
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1095541..1106587

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QA611_RS05190	-	1096682..1097218 (+)	537	WP_001830372.1	hypothetical protein	-
QA611_RS05195	-	1097369..1098355 (-)	987	WP_002457091.1	aromatic acid exporter family protein	-
QA611_RS05200	map	1098529..1099284 (+)	756	WP_001830397.1	type I methionyl aminopeptidase	-
QA611_RS05205	-	1099442..1099828 (+)	387	WP_001830382.1	hypothetical protein	-
QA611_RS05210	liaF	1099843..1100544 (+)	702	WP_002457093.1	cell wall-active antibiotics response protein LiaF	-
QA611_RS05215	vraS	1100541..1101587 (+)	1047	WP_001830374.1	sensor histidine kinase	Regulator
QA611_RS05220	vraR	1101577..1102206 (+)	630	WP_001830439.1	two-component system response regulator VraR	Regulator
QA611_RS05225	-	1102263..1103441 (-)	1179	WP_001830411.1	YihY/virulence factor BrkB family protein	-
QA611_RS05230	-	1103848..1104132 (-)	285	WP_001830401.1	YtxH domain-containing protein	-
QA611_RS05235	-	1104140..1104604 (-)	465	WP_001830437.1	low molecular weight protein-tyrosine-phosphatase	-
QA611_RS05240	-	1104745..1104960 (+)	216	WP_001830421.1	DUF1128 domain-containing protein	-
QA611_RS05245	-	1104962..1106203 (+)	1242	WP_001832467.1	aminopeptidase	-

Sequence

Protein

• Length: 348 a.a.
• Molecular weight: 40066.49 Da
• Isoelectric Point: 5.8512

>NTDB_id=812514 QA611_RS05215 WP_001830374.1 1100541..1101587(+) (vraS) [Staphylococcus epidermidis strain 24FSE04]
MNHYIRAIGSMLILVYSMLIAFLFIDKVFVNIIFFQGMFYTQIFGIPVFLFLNLLIVLLCIIVGSVLAYKINQQNDWIIS
QIERSIEGQTVGINDQNIELYTETIDIYHTLVPLNQELHRLRMKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKESKLEPPLNQQIPILEKMVQDSQLEMRALLLHLRPIGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFEVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNQEDYLLLRIQDNGKGFNVDEKFEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEENSSGD

Nucleotide

• Length: 1047 bp

>NTDB_id=812514 QA611_RS05215 WP_001830374.1 1100541..1101587(+) (vraS) [Staphylococcus epidermidis strain 24FSE04]
ATGAATCACTACATAAGAGCTATAGGCTCAATGCTTATATTAGTATATAGTATGCTTATTGCTTTTTTATTTATTGATAA
AGTGTTTGTAAATATTATCTTTTTTCAGGGGATGTTTTATACACAAATATTTGGAATACCTGTTTTTCTATTTTTAAATT
TATTAATTGTTCTTTTATGTATTATAGTTGGATCTGTTTTAGCTTATAAAATTAATCAACAAAATGATTGGATTATTTCA
CAAATAGAAAGATCAATAGAAGGACAAACAGTAGGTATCAATGATCAAAATATCGAATTATATACAGAAACGATAGATAT
TTATCATACACTAGTTCCATTAAATCAAGAATTACATCGACTTAGAATGAAGACTCAAAATTTAACTAATGAAAACTACA
ATATTAATGATGTAAAAGTCAAAAAGATTATCGAAGATGAGCGACAACGACTTGCCAGGGAATTACATGATTCTGTTAGT
CAACAATTATTTGCTGCGAGCATGATGCTATCGGCGATAAAAGAGTCGAAATTAGAACCACCTTTAAATCAACAGATACC
AATTCTTGAAAAAATGGTTCAAGACTCACAACTTGAAATGAGAGCTTTGTTATTACATTTAAGACCGATAGGTTTAAAAG
ATAAGTCTTTAGGTGAAGGAATTAAAGATTTAGTCATCGATTTACAAAAGAAAGTACCAATGAAAGTTGTGCATGAAATT
CAAGATTTTGAAGTGCCAAAAGGCATTGAAGATCACTTGTTCAGAATTACACAAGAAGCTATTTCAAATACATTGAGACA
TTCAAATGGTACAAAAGTAACTGTGGAATTATTTAATCAAGAGGATTATCTTTTACTAAGAATTCAAGATAATGGAAAAG
GGTTTAATGTAGATGAAAAATTTGAACAAAGTTATGGTTTGAAAAATATGCGAGAACGAGCGTTAGAAATTGGTGCGACG
TTTCATATTGTATCTTTACCTGATTCAGGTACACGAATTGAAGTTAAGGCACCATTGAATAAGGAGGAGAATTCAAGTGG
CGATTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0N1EGU4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	93.023	98.851	0.92