Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   P4B11_RS10145 Genome accession   NZ_CP120652
Coordinates   2018447..2019796 (+) Length   449 a.a.
NCBI ID   WP_000806247.1    Uniprot ID   -
Organism   Staphylococcus aureus strain 205M     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1977141..2040494 2018447..2019796 within 0
SCCmec 2018447..2028151 2018447..2019796 within 0


Gene organization within MGE regions


Location: 1977141..2040494
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  P4B11_RS09950 (P4B11_09985) - 1977454..1979229 (+) 1776 WP_176426625.1 oleate hydratase -
  P4B11_RS09955 (P4B11_09990) - 1979554..1981215 (+) 1662 WP_001800966.1 Na/Pi cotransporter family protein -
  P4B11_RS09960 (P4B11_09995) norC 1981699..1983087 (-) 1389 WP_001006441.1 multidrug efflux MFS transporter NorC -
  P4B11_RS09965 (P4B11_10000) - 1983089..1984267 (-) 1179 WP_001075809.1 M20 family metallopeptidase -
  P4B11_RS09970 (P4B11_10005) aryK 1984418..1986655 (-) 2238 WP_001188472.1 transcriptional regulator AryK -
  P4B11_RS09975 (P4B11_10010) - 1986752..1987522 (-) 771 WP_075339405.1 tandem-type lipoprotein -
  P4B11_RS09980 (P4B11_10015) - 1987586..1988356 (-) 771 WP_000977803.1 tandem-type lipoprotein -
  P4B11_RS09985 (P4B11_10020) - 1988421..1989191 (-) 771 WP_031790901.1 tandem-type lipoprotein -
  P4B11_RS09990 (P4B11_10025) - 1989256..1990026 (-) 771 WP_000597207.1 tandem-type lipoprotein -
  P4B11_RS09995 (P4B11_10030) - 1990078..1990848 (-) 771 WP_000977777.1 tandem-type lipoprotein -
  P4B11_RS10000 (P4B11_10035) - 1991069..1992056 (-) 988 Protein_1936 phosphatidylinositol-specific phospholipase C -
  P4B11_RS10005 (P4B11_10040) - 1992262..1992744 (-) 483 WP_000410567.1 hypothetical protein -
  P4B11_RS10010 (P4B11_10045) - 1992801..1995953 (-) 3153 WP_000080564.1 ATP-binding protein -
  P4B11_RS10015 (P4B11_10050) - 1996206..1996808 (-) 603 WP_000908956.1 hypothetical protein -
  P4B11_RS10020 (P4B11_10055) - 1997016..1997312 (-) 297 WP_000201644.1 TfoX/Sxy family protein -
  P4B11_RS10025 (P4B11_10060) - 1997361..1997564 (-) 204 WP_000389759.1 DUF6007 family protein -
  P4B11_RS10030 (P4B11_10065) - 1997873..1998859 (+) 987 WP_000662022.1 tRNA-dihydrouridine synthase -
  P4B11_RS10035 (P4B11_10070) sqr 1999525..2000718 (-) 1194 WP_001033018.1 type II sulfide:quinone oxidoreductase Sqr -
  P4B11_RS10040 (P4B11_10075) cstB 2000737..2002071 (-) 1335 WP_000465472.1 persulfide dioxygenase-sulfurtransferase CstB -
  P4B11_RS10045 (P4B11_10080) cstA 2002102..2003166 (-) 1065 WP_000816133.1 persulfide response sulfurtransferase CstA -
  P4B11_RS10050 (P4B11_10085) cstR 2003303..2003563 (+) 261 WP_001105088.1 persulfide-sensing transcriptional repressor CstR -
  P4B11_RS10055 (P4B11_10090) - 2003563..2004318 (+) 756 WP_404968712.1 sulfite exporter TauE/SafE family protein -
  P4B11_RS10060 (P4B11_10095) - 2004416..2004504 (+) 89 Protein_1948 hypothetical protein -
  P4B11_RS10065 (P4B11_10100) - 2004809..2005164 (+) 356 Protein_1949 tRNA-dihydrouridine synthase -
  P4B11_RS10070 (P4B11_10105) - 2005262..2007007 (-) 1746 WP_000700190.1 DUF6119 family protein -
  P4B11_RS10075 (P4B11_10110) - 2007154..2007246 (-) 93 WP_001790000.1 hypothetical protein -
  P4B11_RS10080 (P4B11_10115) - 2007210..2007344 (+) 135 WP_001790628.1 hypothetical protein -
  P4B11_RS10085 (P4B11_10120) - 2007621..2007770 (-) 150 WP_001808882.1 hypothetical protein -
  P4B11_RS10090 (P4B11_10125) - 2007772..2008017 (-) 246 WP_002502961.1 hypothetical protein -
  P4B11_RS10095 (P4B11_10130) - 2008037..2008279 (-) 243 WP_223289545.1 hypothetical protein -
  P4B11_RS10100 (P4B11_10140) - 2009048..2009842 (+) 795 WP_000186198.1 SDR family oxidoreductase -
  P4B11_RS10105 (P4B11_10145) - 2009868..2011478 (+) 1611 WP_239682555.1 PRD domain-containing protein -
  P4B11_RS10110 (P4B11_10150) - 2011752..2012225 (+) 474 WP_000897589.1 transcriptional regulator GutM -
  P4B11_RS10115 (P4B11_10155) - 2012209..2012760 (+) 552 WP_000455774.1 PTS glucitol/sorbitol transporter subunit IIC -
  P4B11_RS10120 (P4B11_10160) - 2012772..2013797 (+) 1026 WP_001066642.1 PTS glucitol/sorbitol transporter subunit IIB -
  P4B11_RS10125 (P4B11_10165) - 2013813..2014166 (+) 354 WP_000278595.1 PTS glucitol/sorbitol transporter subunit IIA -
  P4B11_RS10130 (P4B11_10170) - 2014442..2016025 (-) 1584 WP_031898076.1 hypothetical protein -
  P4B11_RS10135 (P4B11_10175) ssb 2016197..2016493 (+) 297 WP_020808054.1 cassette chromosome ssDNA-binding protein -
  P4B11_RS10140 (P4B11_10180) cch1 2016493..2018259 (+) 1767 WP_404968713.1 cassette chromosome replicative helicase -
  P4B11_RS10145 (P4B11_10185) ccrA 2018447..2019796 (+) 1350 WP_000806247.1 cassette chromosome recombinase CcrA Machinery gene
  P4B11_RS10150 (P4B11_10190) ccrB 2019818..2021442 (+) 1625 Protein_1966 cassette chromosome recombinase CcrB -
  P4B11_RS10155 (P4B11_10195) - 2021908..2022258 (+) 351 WP_000859157.1 SAUGI family uracil-DNA glycosylase inhibitor -
  P4B11_RS10160 (P4B11_10200) - 2022345..2022656 (+) 312 WP_001024803.1 DUF960 family protein -
  P4B11_RS10165 (P4B11_10205) - 2022671..2023177 (+) 507 WP_001092195.1 DUF1643 domain-containing protein -
  P4B11_RS10170 (P4B11_10210) - 2023226..2024836 (+) 1611 Protein_1970 IS1182 family transposase -
  P4B11_RS10175 (P4B11_10215) - 2024827..2025069 (-) 243 Protein_1971 type I restriction enzyme endonuclease domain-containing protein -
  P4B11_RS10180 (P4B11_10220) - 2025059..2026045 (-) 987 WP_001549960.1 beta-lactam sensor/signal transducer MecR1 -
  P4B11_RS10185 (P4B11_10225) mecA 2026142..2028151 (+) 2010 WP_063852655.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  P4B11_RS10190 (P4B11_10230) - 2028197..2028625 (-) 429 WP_000872606.1 MaoC family dehydratase -
  P4B11_RS10195 (P4B11_10235) - 2028722..2029465 (-) 744 WP_000958858.1 glycerophosphoryl diester phosphodiesterase -
  P4B11_RS10200 (P4B11_10240) - 2030342..2030731 (-) 390 WP_020444595.1 hydroxymethylglutaryl-CoA synthase -
  P4B11_RS10205 (P4B11_10245) - 2030767..2031441 (+) 675 WP_001106057.1 IS6-like element IS257 family transposase -
  P4B11_RS10210 (P4B11_10250) mobV 2031579..2032841 (-) 1263 WP_404968714.1 MobV family relaxase -
  P4B11_RS10215 (P4B11_10255) bleO 2033348..2033752 (-) 405 WP_001242578.1 bleomycin binding protein -
  P4B11_RS10220 (P4B11_10260) aadD1 2033969..2034739 (-) 771 WP_001795128.1 aminoglycoside O-nucleotidyltransferase ANT(4')-Ia -
  P4B11_RS10225 (P4B11_10265) - 2034899..2035903 (-) 1005 Protein_1981 protein rep -
  P4B11_RS10230 (P4B11_10270) - 2036113..2036787 (+) 675 WP_001106057.1 IS6-like element IS257 family transposase -
  P4B11_RS10235 (P4B11_10275) - 2036819..2037058 (-) 240 WP_001282728.1 hypothetical protein -
  P4B11_RS10240 (P4B11_10280) - 2037473..2038729 (-) 1257 WP_000566670.1 MrcB family domain-containing protein -
  P4B11_RS10245 (P4B11_10285) rlmH 2039051..2039530 (-) 480 WP_000704775.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -

Sequence

Protein


Download         Length: 449 a.a.        Molecular weight: 52580.41 Da        Isoelectric Point: 9.9370

>NTDB_id=807481 P4B11_RS10145 WP_000806247.1 2018447..2019796(+) (ccrA) [Staphylococcus aureus strain 205M]
MKQAIGYLRQSTTKQQSLAAQKQTIEALAKKHNIQYITFYSDKQSGRTDKRNGYQQITELIQQGQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFISLAELESDNIGEQVKNGIKEKAKQGKMITTHAPFGYHYH
NGTFTIDTVKAPTVKAVFNYYLQGYGYKKIAQYLEADDKFINRKPYQVRNIILNPNYCGRVINQYGQYENMFPAIVSTTI
YEEAQVTRTQKPVKRKPSENQLKQKIKCPYCDSTLTNMTIRKKHHTLRYYVCPQNMNASRFVCEFKGINAQELETSVLAT
CQDFFQNQQLYSKINHTIQQRLKRQRDIETKTTLNHEQLIEKLAQDKIDAETFREQTQSLRQQSKPISSISTYQIRKAFQ
NIIQQRFTLNMLYPYIDEINISKNKSLAGIYFKNEPLNIVKQTMELSIV

Nucleotide


Download         Length: 1350 bp        

>NTDB_id=807481 P4B11_RS10145 WP_000806247.1 2018447..2019796(+) (ccrA) [Staphylococcus aureus strain 205M]
ATGAAACAAGCAATAGGTTACTTACGACAGAGCACTACAAAGCAACAATCCTTAGCAGCACAAAAACAAACCATCGAGGC
ATTAGCCAAAAAACATAATATTCAATACATTACCTTTTATAGCGATAAGCAATCAGGACGCACTGATAAGCGGAACGGTT
ACCAACAAATTACTGAACTGATTCAACAAGGACAATGTGATGTATTATGTTGTTACAGATTAAACCGACTTCATCGCAAT
CTTAAAAATGCATTAAAACTCATGAAATTGTGTCAAAAATACCATGTCCATATCTTAAGCGTTCATGATGGCTATTTTGA
TATGGATAAAGCATTCGATCGGCTCAAACTCAATATTTTCATCAGCTTGGCCGAACTAGAATCTGATAATATAGGCGAAC
AAGTCAAAAATGGAATCAAAGAAAAAGCGAAACAAGGTAAAATGATTACAACACATGCACCCTTTGGGTATCACTATCAT
AATGGTACTTTCACGATAGACACAGTAAAAGCACCAACAGTAAAAGCTGTGTTCAATTATTACCTTCAAGGTTATGGTTA
TAAAAAAATTGCGCAATACTTAGAAGCTGATGATAAATTCATTAATCGTAAGCCCTATCAAGTGCGTAATATTATCCTTA
ACCCTAATTACTGTGGCCGTGTTATCAATCAATACGGACAATATGAAAACATGTTCCCAGCTATTGTCAGTACAACGATA
TACGAAGAAGCTCAAGTTACCCGAACTCAGAAACCAGTAAAACGTAAGCCGTCAGAAAACCAACTCAAACAAAAAATCAA
ATGTCCTTATTGTGATTCAACACTAACTAATATGACCATTAGAAAAAAGCACCATACATTACGTTATTATGTTTGTCCTC
AAAATATGAATGCATCTCGTTTTGTCTGTGAATTCAAAGGGATCAACGCACAAGAATTAGAAACAAGTGTTTTAGCGACT
TGTCAGGACTTCTTTCAAAATCAACAGCTCTATTCAAAAATAAACCATACTATTCAACAACGACTCAAAAGACAAAGAGA
TATAGAAACTAAAACTACACTCAATCACGAGCAGCTGATAGAAAAATTAGCCCAAGACAAAATTGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAGCAATCAAAACCTATATCATCAATCAGTACGTATCAAATTCGAAAAGCTTTCCAA
AACATCATTCAACAACGTTTCACGCTAAACATGTTGTACCCCTATATTGATGAAATTAATATTTCTAAAAATAAAAGCCT
CGCTGGCATCTATTTCAAAAATGAACCACTGAATATTGTAAAGCAGACTATGGAATTATCAATTGTATAA

Domains

Predicted by InterproScan.

Resolvase, N terminal domain (Resolvase)

(4-147)

Recombinase (Recombinase)

(170-249)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-322)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus COL

100

100

1
  ccrA Staphylococcus aureus N315

74.833

100

0.748