Detailed information NTG0807178

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: RL452_RS12575
• Genome accession: NZ_CP134620
• Coordinates: 2524119..2526227 (+)
• Length: 702 a.a.
• NCBI ID: WP_001063340.1
• Uniprot ID: Q2YWB1
• Organism: Staphylococcus aureus strain Sa9
• Function: repress competence development (at the early growth phase) (predicted from homology) Competence regulation

Genomic Context

Location: 2519119..2531227

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RL452_RS12555 (RL452_12545)	-	2519441..2520721 (-)	1281	WP_001191012.1	hydroxymethylglutaryl-CoA reductase, degradative	-
RL452_RS12560 (RL452_12550)	-	2520975..2522141 (+)	1167	WP_000151979.1	hydroxymethylglutaryl-CoA synthase	-
RL452_RS12565 (RL452_12555)	sey	2522370..2523035 (-)	666	WP_000644941.1	staphylococcal enterotoxin type Y	-
RL452_RS12570 (RL452_12560)	-	2523236..2523757 (-)	522	WP_000262596.1	methylated-DNA--[protein]-cysteine S-methyltransferase	-
RL452_RS12575 (RL452_12565)	clpE	2524119..2526227 (+)	2109	WP_001063340.1	ATP-dependent Clp protease ATP-binding subunit ClpL	Regulator
RL452_RS12580 (RL452_12570)	-	2526294..2526464 (-)	171	WP_000111120.1	FeoB-associated Cys-rich membrane protein	-
RL452_RS12585 (RL452_12575)	feoB	2526477..2528471 (-)	1995	WP_000432893.1	ferrous iron transport protein B	-
RL452_RS12590 (RL452_12580)	-	2528483..2528710 (-)	228	WP_000932073.1	ferrous iron transport protein A	-

Sequence

Protein

• Length: 702 a.a.
• Molecular weight: 78092.61 Da
• Isoelectric Point: 4.6875

>NTDB_id=807178 RL452_RS12575 WP_001063340.1 2524119..2526227(+) (clpE) [Staphylococcus aureus strain Sa9]
MNNNFFNSDFDSILRRMMQDMQNSNQTSNKKYYINGKEVSQEELAQFTQQGGNHSAEQSAQAFQQAALRQQGQQSGNGNY
LEQIGRNLTQEARDGLLDPVIGRDKEIQETAEVLSRRTKNNPILVGEAGVGKTAIVEGLAQAIVEGNVPAAIKDKEIISI
DISSLEAGTQYRGAFEENIQKLVEGVKSSQNAVLFFDEIHQIIGSGATGSDSGSKGLSDILKPALSRGEISIIGATTQDE
YRNNILKDAALTRRFNEVLVNEPSAKDTVEILKGIREKFETHHQVKLPDDVLKACVDLSIQYIPQRLLPDKAIDVLDITA
AHLSAQSPAIDKVATEKRISELEHDKRKAVSAEEYKKADDIQNEIKSLQDKLENSNGEHTAVATVHDISDTIQRLTGIPV
SQMDANDIERLKNISSRLRSKIIGQDKAVEMVSRAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLAIDLFGNKEA
LIRLDMSEYSDTTAISKMIGTTAGYVGYDDNSNTLTEKVRRNPYSVILFDEIEKANPQILTLLLQVMDDGNLTDGQGNVI
NFKNTIIICTSNAGFGNGTDQEYDDIMQEMKKFFRPEFLNRFNGIVEFLHLDKDALQDIVNLLLDDVQVTLDKKGITMNV
SQDAKDWLIEEGYDEELGARPLRRIVEQQVRDKITDYYLDHTDVKHVDLDIEDNELVVKGKS

Nucleotide

• Length: 2109 bp

>NTDB_id=807178 RL452_RS12575 WP_001063340.1 2524119..2526227(+) (clpE) [Staphylococcus aureus strain Sa9]
ATGAATAACAATTTTTTCAATAGTGACTTCGATTCTATTTTACGAAGAATGATGCAAGACATGCAAAACTCAAATCAGAC
TAGTAACAAGAAATACTATATTAATGGTAAAGAAGTTTCACAGGAAGAATTAGCACAATTTACGCAACAAGGTGGTAATC
ATTCTGCCGAACAAAGTGCGCAAGCTTTTCAACAAGCAGCACTAAGACAACAAGGTCAACAAAGTGGCAATGGCAATTAT
TTAGAACAAATTGGTCGTAACTTAACGCAAGAGGCTCGTGACGGATTATTAGATCCAGTCATCGGTCGTGATAAAGAAAT
CCAAGAAACTGCAGAAGTCTTAAGTAGACGCACTAAAAACAATCCTATCCTAGTCGGAGAAGCTGGAGTTGGTAAAACTG
CGATTGTCGAAGGTTTAGCGCAAGCAATCGTTGAAGGGAACGTACCTGCAGCAATCAAAGATAAAGAAATTATATCTATA
GATATTTCATCGCTTGAAGCTGGAACGCAATATCGTGGCGCCTTTGAAGAAAACATCCAAAAGTTAGTTGAAGGCGTTAA
ATCATCACAAAATGCTGTGCTCTTCTTTGACGAAATTCACCAAATCATCGGTTCCGGCGCAACAGGAAGTGATTCTGGTA
GTAAAGGGTTATCTGATATTTTAAAACCAGCATTAAGTCGTGGTGAAATTTCAATTATAGGTGCAACGACTCAAGATGAA
TATCGCAATAATATCCTGAAAGACGCTGCATTAACACGTCGTTTTAACGAGGTACTGGTTAACGAACCAAGCGCAAAAGA
TACGGTTGAAATTTTAAAAGGAATTCGCGAAAAATTTGAAACACACCATCAAGTCAAATTACCTGATGACGTATTAAAGG
CATGTGTAGACTTATCCATTCAATATATTCCACAACGCTTATTACCTGACAAAGCAATCGATGTATTAGATATTACAGCT
GCACATTTATCTGCACAAAGCCCTGCTATTGATAAAGTTGCGACTGAAAAACGTATTTCTGAATTGGAACATGATAAGCG
TAAAGCTGTAAGTGCTGAAGAATATAAAAAAGCAGATGACATTCAAAATGAAATTAAATCTCTACAAGATAAATTAGAAA
ACAGTAATGGTGAACATACTGCAGTAGCAACGGTGCATGATATTTCTGATACCATTCAACGATTAACTGGTATTCCTGTA
TCTCAAATGGATGCCAATGACATTGAACGTTTAAAAAATATTTCTAGTCGTTTAAGAAGTAAAATCATCGGTCAAGATAA
AGCTGTAGAAATGGTTTCTCGTGCCATTCGTCGTAATCGAGCTGGTTTTGATGATGGCAATCGTCCAATTGGTAGCTTCC
TATTTGTCGGTCCTACTGGTGTTGGTAAAACAGAGCTTGCCAAACAGTTAGCCATTGATTTATTTGGTAATAAAGAAGCA
CTGATTCGACTTGATATGAGTGAATATAGTGATACTACTGCTATTTCTAAAATGATTGGTACAACTGCTGGTTATGTCGG
TTATGACGATAATTCAAATACATTAACTGAAAAAGTACGACGCAATCCATATTCAGTCATTCTATTTGATGAAATTGAAA
AGGCTAATCCACAAATATTAACATTATTACTACAAGTGATGGATGATGGTAATTTAACAGATGGTCAAGGTAACGTCATC
AACTTTAAAAACACAATCATTATTTGTACGTCAAACGCTGGTTTTGGTAACGGTACAGACCAAGAATACGATGACATTAT
GCAAGAAATGAAAAAATTCTTCCGCCCTGAATTTCTTAACCGCTTCAACGGCATCGTTGAATTCTTACATTTAGATAAAG
ATGCATTACAAGATATCGTCAACTTATTATTAGACGATGTACAAGTTACATTAGATAAAAAAGGTATTACGATGAATGTC
TCTCAAGATGCAAAAGATTGGTTAATTGAAGAGGGATATGATGAAGAGTTAGGCGCACGCCCATTAAGACGCATTGTTGA
ACAACAAGTGCGTGACAAAATAACAGATTATTATTTAGATCATACAGACGTTAAACATGTGGATTTAGATATCGAAGACA
ACGAATTAGTCGTCAAAGGTAAATCATGA

Domains

Predicted by InterProScan.

• AAA lid domain (AAA_lid_9) (264-363)

• ATPase family associated with various cellular activities (AAA) (AAA) (123-257)

• AAA domain (Cdc48 subfamily) (AAA_2) (448-603)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (611-682)

3D structure

• AlphaFold DB: Q2YWB1

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus mutans UA159	47.9	91.595	0.439
clpE	Streptococcus pneumoniae Rx1	47.488	87.892	0.417
clpE	Streptococcus pneumoniae D39	47.488	87.892	0.417
clpE	Streptococcus pneumoniae R6	47.488	87.892	0.417
clpE	Streptococcus pneumoniae TIGR4	47.488	87.892	0.417
clpC	Lactococcus lactis subsp. cremoris KW2	46.044	90.028	0.415
clpC	Bacillus subtilis subsp. subtilis str. 168	44.037	93.162	0.41
clpC	Streptococcus thermophilus LMD-9	44.96	89.031	0.4
clpC	Streptococcus thermophilus LMG 18311	44.8	89.031	0.399
clpC	Streptococcus pneumoniae TIGR4	43.77	89.174	0.39
clpC	Streptococcus pneumoniae Rx1	43.77	89.174	0.39
clpC	Streptococcus pneumoniae D39	43.77	89.174	0.39
clpC	Streptococcus mutans UA159	43.902	87.607	0.385
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	42.376	88.746	0.376