Detailed information
Bioinformatically predicted
Overview
| Name | ccrB | Type | Machinery gene |
| Locus tag | P5W75_RS04010 | Genome accession | NZ_CP120423 |
| Coordinates | 866193..867821 (+) | Length | 542 a.a. |
| NCBI ID | WP_001186608.1 | Uniprot ID | - |
| Organism | Staphylococcus epidermidis strain 41DSE01 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| SCCmec | 799385..874587 | 866193..867821 | within | 0 |
Gene organization within MGE regions
Location: 799385..874587
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| P5W75_RS03710 | - | 799385..801310 (-) | 1926 | WP_002485723.1 | heavy metal translocating P-type ATPase | - |
| P5W75_RS03715 | - | 801640..801966 (-) | 327 | WP_000391495.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| P5W75_RS03720 | - | 802173..802532 (+) | 360 | WP_001631039.1 | hypothetical protein | - |
| P5W75_RS03725 | - | 802644..802982 (-) | 339 | Protein_729 | recombinase family protein | - |
| P5W75_RS03730 | - | 802991..803620 (+) | 630 | Protein_730 | hypothetical protein | - |
| P5W75_RS03735 | - | 803807..805168 (+) | 1362 | Protein_731 | recombinase family protein | - |
| P5W75_RS03740 | ccrB | 805165..806793 (+) | 1629 | WP_001631035.1 | recombinase family protein | Machinery gene |
| P5W75_RS03745 | - | 807294..807644 (+) | 351 | WP_001631034.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| P5W75_RS03750 | - | 807731..808042 (+) | 312 | WP_001631033.1 | DUF960 domain-containing protein | - |
| P5W75_RS03755 | - | 808058..808561 (+) | 504 | WP_001631032.1 | DUF1643 domain-containing protein | - |
| P5W75_RS03760 | - | 808576..808796 (+) | 221 | Protein_736 | hypothetical protein | - |
| P5W75_RS03765 | - | 808959..809369 (+) | 411 | WP_001631031.1 | DUF2871 domain-containing protein | - |
| P5W75_RS03770 | - | 810041..810538 (+) | 498 | WP_001631030.1 | GNAT family N-acetyltransferase | - |
| P5W75_RS03775 | - | 810600..810816 (+) | 217 | Protein_739 | IS5/IS1182 family transposase | - |
| P5W75_RS03780 | - | 810861..812063 (-) | 1203 | WP_001631029.1 | restriction endonuclease subunit S | - |
| P5W75_RS03785 | - | 812056..812199 (-) | 144 | WP_001631028.1 | restriction endonuclease subunit R | - |
| P5W75_RS03790 | - | 812805..813440 (-) | 636 | WP_002469410.1 | ATP-binding cassette domain-containing protein | - |
| P5W75_RS03795 | - | 813433..814200 (-) | 768 | WP_002469398.1 | ATP-binding cassette domain-containing protein | - |
| P5W75_RS03800 | - | 814167..814934 (-) | 768 | WP_002469402.1 | ABC transporter permease | - |
| P5W75_RS03805 | - | 814934..815890 (-) | 957 | WP_002467620.1 | ABC transporter permease | - |
| P5W75_RS03810 | - | 815893..817446 (-) | 1554 | WP_002469417.1 | ABC transporter substrate-binding protein | - |
| P5W75_RS03815 | - | 817443..818135 (-) | 693 | WP_002467668.1 | class I SAM-dependent methyltransferase | - |
| P5W75_RS03820 | - | 818302..819247 (-) | 946 | Protein_748 | DUF3387 domain-containing protein | - |
| P5W75_RS03825 | - | 819951..820397 (+) | 447 | WP_000711814.1 | ArgR family transcriptional regulator | - |
| P5W75_RS03830 | arcA | 820666..821901 (+) | 1236 | WP_000249804.1 | arginine deiminase | - |
| P5W75_RS03835 | arcD | 821987..823408 (+) | 1422 | WP_000344142.1 | arginine-ornithine antiporter | - |
| P5W75_RS03840 | - | 823450..824139 (+) | 690 | WP_000272781.1 | Crp/Fnr family transcriptional regulator | - |
| P5W75_RS03845 | argF | 824177..825175 (+) | 999 | WP_000793596.1 | ornithine carbamoyltransferase | - |
| P5W75_RS03850 | arcC | 825195..826124 (+) | 930 | WP_000036757.1 | carbamate kinase | - |
| P5W75_RS03855 | - | 826224..827075 (-) | 852 | Protein_755 | IS3 family transposase | - |
| P5W75_RS03860 | - | 827302..827667 (-) | 366 | Protein_756 | diaminopimelate epimerase | - |
| P5W75_RS03865 | - | 827981..828322 (+) | 342 | WP_001830719.1 | hypothetical protein | - |
| P5W75_RS03870 | kdpC | 828631..829191 (-) | 561 | WP_001830712.1 | K(+)-transporting ATPase subunit C | - |
| P5W75_RS03875 | - | 829206..831227 (-) | 2022 | WP_032601514.1 | K(+)-transporting ATPase subunit B | - |
| P5W75_RS03880 | kdpA | 831246..832928 (-) | 1683 | WP_002505145.1 | potassium-transporting ATPase subunit KdpA | - |
| P5W75_RS03885 | - | 832949..833029 (-) | 81 | WP_001830720.1 | potassium-transporting ATPase subunit F | - |
| P5W75_RS03890 | - | 833196..835850 (+) | 2655 | WP_001830698.1 | sensor histidine kinase KdpD | - |
| P5W75_RS03895 | - | 835855..836568 (+) | 714 | WP_001830710.1 | response regulator transcription factor | - |
| P5W75_RS03900 | - | 837173..837844 (-) | 672 | Protein_764 | IS6 family transposase | - |
| P5W75_RS03905 | - | 837874..838029 (-) | 156 | WP_001830703.1 | hypothetical protein | - |
| P5W75_RS03910 | - | 839393..840289 (+) | 897 | WP_002469425.1 | hypothetical protein | - |
| P5W75_RS03915 | - | 840286..841023 (-) | 738 | WP_024051414.1 | hypothetical protein | - |
| P5W75_RS03920 | - | 841435..842931 (+) | 1497 | WP_002469396.1 | class I SAM-dependent DNA methyltransferase | - |
| P5W75_RS03925 | - | 842921..844177 (+) | 1257 | WP_002469391.1 | restriction endonuclease subunit S | - |
| P5W75_RS03930 | - | 844161..847280 (+) | 3120 | WP_002469414.1 | type I restriction endonuclease subunit R | - |
| P5W75_RS03935 | gtfB | 847388..848707 (-) | 1320 | WP_002469407.1 | accessory Sec system glycosylation chaperone GtfB | - |
| P5W75_RS03940 | gtfA | 848700..850208 (-) | 1509 | WP_001551920.1 | accessory Sec system glycosyltransferase GtfA | - |
| P5W75_RS03945 | sesJ | 850297..853440 (-) | 3144 | WP_277374990.1 | MSCRAMM family cell wall-anchored protein SesJ | - |
| P5W75_RS03950 | - | 853686..853919 (+) | 234 | WP_002467980.1 | hypothetical protein | - |
| P5W75_RS03955 | - | 854111..854459 (-) | 349 | Protein_775 | helix-turn-helix domain-containing protein | - |
| P5W75_RS03960 | - | 855173..855802 (-) | 630 | WP_002469297.1 | hypothetical protein | - |
| P5W75_RS03965 | - | 856214..856834 (-) | 621 | WP_000673114.1 | hypothetical protein | - |
| P5W75_RS03970 | - | 856963..857334 (-) | 372 | WP_001549968.1 | HNH endonuclease | - |
| P5W75_RS03975 | - | 857331..857468 (-) | 138 | WP_001791883.1 | hypothetical protein | - |
| P5W75_RS03980 | cstB | 857524..858842 (+) | 1319 | Protein_780 | persulfide dioxygenase-sulfurtransferase CstB | - |
| P5W75_RS03985 | - | 859215..860705 (-) | 1491 | WP_000554504.1 | RNA-binding domain-containing protein | - |
| P5W75_RS03990 | - | 861323..862372 (-) | 1050 | WP_000613248.1 | hypothetical protein | - |
| P5W75_RS03995 | - | 862511..862801 (+) | 291 | WP_001036438.1 | hypothetical protein | - |
| P5W75_RS04000 | - | 862801..864588 (+) | 1788 | WP_000122620.1 | DUF927 domain-containing protein | - |
| P5W75_RS04005 | ccrA | 864822..866171 (+) | 1350 | WP_000815640.1 | recombinase family protein | Machinery gene |
| P5W75_RS04010 | ccrB | 866193..867821 (+) | 1629 | WP_001186608.1 | recombinase family protein | Machinery gene |
| P5W75_RS04015 | - | 868343..868693 (+) | 351 | WP_000849672.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| P5W75_RS04020 | - | 868780..869091 (+) | 312 | WP_000700851.1 | DUF960 family protein | - |
| P5W75_RS04025 | - | 869106..869612 (+) | 507 | WP_001092189.1 | DUF1643 domain-containing protein | - |
| P5W75_RS04030 | - | 869664..871272 (+) | 1609 | Protein_790 | IS1182 family transposase | - |
| P5W75_RS04035 | - | 871263..871523 (-) | 261 | WP_001549961.1 | type I restriction enzyme endonuclease domain-containing protein | - |
| P5W75_RS04040 | - | 871495..872481 (-) | 987 | WP_001549960.1 | beta-lactam sensor/signal transducer MecR1 | - |
| P5W75_RS04045 | mecA | 872578..874587 (+) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
Sequence
Protein
Download Length: 542 a.a. Molecular weight: 62654.83 Da Isoelectric Point: 9.7970
>NTDB_id=805593 P5W75_RS04010 WP_001186608.1 866193..867821(+) (ccrB) [Staphylococcus epidermidis strain 41DSE01]
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRMLKDAKEGNIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFECYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPVIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEDYVMKQILEIVKSDKVIQRVVTHVNQENQVDGAALHHDIAYKQQQYD
EVQIKINNLIKTIEDNPDLTSVIRPSIQKYEKQLNDITNQINQLKNQQNEDKTLFDAKEISKLLQHIFHDIKHIEKSRLK
ALYLSVIDRIDIKKDGNHKKQFYVTLKLNNEIIKQLFNNKQLDEVHLSTSSLFLPQTLYLTI
MQQLKTKRVGIYVRVSTEMQSTEGYSIDGQINQIKEYCDFHHFEVKDIYADRGISGKSMNRPELQRMLKDAKEGNIDCVM
VYKTNRLARNTSDLLKIVEDLHKQNVEFFSLSERMEVNTSSGKLMLQILASFSEFERNNIVENVFMGQTRRAQEGYYQGN
LPLGYDKIPDSKHELMINQHEANIVKYIFECYAKGHGYRKIANALNHKGYVTKKGKPFSISSITYILANPFYIGKIQFAK
YKDWSEKRRKGLNDKPVIAEGKHSPIINQDLWDKVQMRKKQVSQKPQVHGKGTNLLTGIIHCPQCGAPMAASNTTNTLKD
GTKKRIRYYSCSNFRNKGSKVCSANSVRADVIEDYVMKQILEIVKSDKVIQRVVTHVNQENQVDGAALHHDIAYKQQQYD
EVQIKINNLIKTIEDNPDLTSVIRPSIQKYEKQLNDITNQINQLKNQQNEDKTLFDAKEISKLLQHIFHDIKHIEKSRLK
ALYLSVIDRIDIKKDGNHKKQFYVTLKLNNEIIKQLFNNKQLDEVHLSTSSLFLPQTLYLTI
Nucleotide
Download Length: 1629 bp
>NTDB_id=805593 P5W75_RS04010 WP_001186608.1 866193..867821(+) (ccrB) [Staphylococcus epidermidis strain 41DSE01]
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTATCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGACGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAAGTTAAAGATATATACGCTGACCGTGGTA
TTTCAGGTAAATCTATGAACAGACCTGAGCTCCAACGTATGTTGAAAGATGCAAAAGAAGGCAATATCGACTGTGTTATG
GTATACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTCAGTTTGTCAGAGCGTATGGAAGTCAATACTTCTTCTGGTAAACTCATGTTACAGATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAACGTATTTATGGGTCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGCAAT
TTACCACTAGGTTATGACAAAATACCAGATAGTAAACACGAGCTAATGATTAACCAACATGAAGCTAATATTGTAAAATA
TATATTCGAGTGCTATGCCAAAGGACATGGCTATCGTAAAATTGCCAATGCATTGAATCACAAAGGATATGTCACTAAAA
AGGGGAAACCTTTCAGTATTAGTTCAATCACATACATCTTAGCTAACCCTTTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTGAATGATAAACCAGTGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAGAAACAAGTCAGTCAAAAACCCCAAGTCCATGGCAAAGGAACGA
ATCTGCTTACAGGCATTATTCACTGTCCCCAATGTGGCGCACCTATGGCAGCAAGCAATACCACGAATACTCTTAAAGAC
GGGACTAAGAAACGTATTCGTTACTATTCATGTAGTAATTTTCGGAACAAGGGTTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTGATGTGATTGAAGATTATGTGATGAAGCAAATACTTGAAATAGTCAAAAGTGATAAAGTCATTCAACGCGTAG
TAACACACGTCAATCAAGAAAATCAAGTTGATGGCGCTGCACTTCATCACGATATTGCTTATAAGCAACAACAATATGAT
GAAGTACAAATCAAAATAAATAACTTGATTAAAACCATCGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGCAACTCAATGACATTACGAATCAAATCAACCAACTCAAAAATCAACAAAATGAAGATAAGACTT
TATTTGATGCCAAAGAAATCAGTAAACTATTACAACACATCTTTCATGATATTAAGCACATAGAAAAATCTCGACTCAAA
GCATTGTATCTATCAGTGATTGATCGCATTGATATTAAAAAAGATGGTAATCATAAAAAACAATTCTATGTCACACTCAA
ACTTAATAACGAAATCATTAAACAACTTTTCAATAATAAACAACTCGACGAAGTGCATCTCAGCACTTCGTCTTTATTTT
TGCCCCAAACACTATATCTTACTATTTAG
ATGCAACAACTTAAAACAAAACGTGTCGGTATCTATGTACGTGTATCAACAGAAATGCAAAGCACAGAAGGTTATAGTAT
CGACGGACAAATCAATCAAATCAAAGAATACTGTGACTTCCATCATTTTGAAGTTAAAGATATATACGCTGACCGTGGTA
TTTCAGGTAAATCTATGAACAGACCTGAGCTCCAACGTATGTTGAAAGATGCAAAAGAAGGCAATATCGACTGTGTTATG
GTATACAAAACAAACCGATTAGCTCGTAATACATCTGATCTTCTCAAAATTGTCGAAGATTTACACAAACAAAATGTCGA
ATTTTTCAGTTTGTCAGAGCGTATGGAAGTCAATACTTCTTCTGGTAAACTCATGTTACAGATACTTGCGAGTTTCTCAG
AATTCGAACGTAATAACATTGTCGAGAACGTATTTATGGGTCAAACGAGACGTGCCCAAGAAGGCTATTATCAAGGCAAT
TTACCACTAGGTTATGACAAAATACCAGATAGTAAACACGAGCTAATGATTAACCAACATGAAGCTAATATTGTAAAATA
TATATTCGAGTGCTATGCCAAAGGACATGGCTATCGTAAAATTGCCAATGCATTGAATCACAAAGGATATGTCACTAAAA
AGGGGAAACCTTTCAGTATTAGTTCAATCACATACATCTTAGCTAACCCTTTCTATATCGGCAAAATTCAATTTGCGAAA
TACAAAGATTGGAGTGAAAAACGTCGTAAAGGGCTGAATGATAAACCAGTGATAGCTGAAGGTAAGCATTCCCCCATTAT
TAATCAAGATTTATGGGATAAAGTACAAATGCGTAAGAAACAAGTCAGTCAAAAACCCCAAGTCCATGGCAAAGGAACGA
ATCTGCTTACAGGCATTATTCACTGTCCCCAATGTGGCGCACCTATGGCAGCAAGCAATACCACGAATACTCTTAAAGAC
GGGACTAAGAAACGTATTCGTTACTATTCATGTAGTAATTTTCGGAACAAGGGTTCCAAAGTATGTTCGGCAAACAGTGT
AAGAGCTGATGTGATTGAAGATTATGTGATGAAGCAAATACTTGAAATAGTCAAAAGTGATAAAGTCATTCAACGCGTAG
TAACACACGTCAATCAAGAAAATCAAGTTGATGGCGCTGCACTTCATCACGATATTGCTTATAAGCAACAACAATATGAT
GAAGTACAAATCAAAATAAATAACTTGATTAAAACCATCGAGGATAATCCGGACTTAACATCAGTAATCAGACCAAGTAT
TCAAAAATATGAAAAGCAACTCAATGACATTACGAATCAAATCAACCAACTCAAAAATCAACAAAATGAAGATAAGACTT
TATTTGATGCCAAAGAAATCAGTAAACTATTACAACACATCTTTCATGATATTAAGCACATAGAAAAATCTCGACTCAAA
GCATTGTATCTATCAGTGATTGATCGCATTGATATTAAAAAAGATGGTAATCATAAAAAACAATTCTATGTCACACTCAA
ACTTAATAACGAAATCATTAAACAACTTTTCAATAATAAACAACTCGACGAAGTGCATCTCAGCACTTCGTCTTTATTTT
TGCCCCAAACACTATATCTTACTATTTAG
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrB | Staphylococcus aureus N315 |
98.893 |
100 |
0.989 |